node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
act-5 | cdk-5 | T25C8.2.2 | T27E9.3.1 | ACTin. | Cyclin-dependent-like kinase 5; Proline-directed serine/threonine-protein kinase which, in several motor neurons, promotes the polarized trafficking of synaptic vesicles and dense-core vesicles (DCV). In the ventral nerve cord, phosphorylates lin-10 and thereby prevents lin-10-mediated anterograde trafficking of the glutamate receptor glr-1. Involved in the inhibition of glr-1 trafficking in hypoxic conditions. In DA motor neurons but not in DB motor neurons, regulates axonal transport of synaptic vesicle precursors by inhibiting dynein-mediated retrograde transport. Regulates the traf [...] | 0.820 |
act-5 | daf-2 | T25C8.2.2 | Y55D5A.5c.2 | ACTin. | Insulin-like receptor subunit alpha; Insulin receptor-like tyrosine kinase which regulates metabolism, controls longevity and prevents developmental arrest at the dauer stage. Binding of INS family members may either stimulate, or antagonize, association of the receptor with downstream mediators such as pdk-1 and age-1. Required for germline progenitor proliferation during larval development. Required for the response to environmental stimuli such as food, pheromone, and temperature. Negatively regulates resistance to UV and oxidative stress. Role in immune function and pathogen resist [...] | 0.476 |
act-5 | erm-1 | T25C8.2.2 | C01G8.5b.1 | ACTin. | FERM domain-containing protein. | 0.816 |
act-5 | fln-1 | T25C8.2.2 | Y66H1B.2l.2 | ACTin. | Calponin-homology (CH) domain-containing protein. | 0.993 |
act-5 | fln-2 | T25C8.2.2 | C23F12.1a.1 | ACTin. | FiLamiN (Actin binding protein) homolog. | 0.989 |
act-5 | rhi-1 | T25C8.2.2 | F46H6.1.1 | ACTin. | Probable rho GDP-dissociation inhibitor; Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. | 0.777 |
act-5 | rho-1 | T25C8.2.2 | Y51H4A.3a.1 | ACTin. | Ras-like GTP-binding protein rhoA; Required for ventral migration of epidermal cells during ventral enclosure in the embryo and for cell elongation. Also required for ventral migration of P cells during larval development. Involved in asymmetric spindle positioning during anaphase and establishment of cell polarity during embryo development. In adults, involved in regulation of multiple processes including locomotion, pharyngeal pumping, fecundity, ovulation, defecation and body morphology. In body wall muscles, regulates organization of myosin thick filaments downstream of unc-89. Ass [...] | 0.989 |
act-5 | snt-3 | T25C8.2.2 | Y75B7AL.3.1 | ACTin. | SyNapTotagmin. | 0.700 |
act-5 | snt-4 | T25C8.2.2 | T23H2.2.1 | ACTin. | SyNapTotagmin. | 0.715 |
act-5 | snt-5 | T25C8.2.2 | R12A1.2a.1 | ACTin. | SyNapTotagmin. | 0.700 |
act-5 | snt-6 | T25C8.2.2 | C08G5.4a.1 | ACTin. | C2 domain-containing protein. | 0.741 |
act-5 | snt-7 | T25C8.2.2 | T10B10.5.1 | ACTin. | C2 domain-containing protein. | 0.699 |
act-5 | spc-1 | T25C8.2.2 | K10B3.10b.1 | ACTin. | SPeCtrin. | 0.587 |
act-5 | unc-60 | T25C8.2.2 | C38C3.5.1 | ACTin. | Actin-depolymerizing factor 2, isoform c; Depolymerizes growing actin filaments in muscle cells; required for the assembly of actin filaments into the functional contractile myofilament lattice of muscle. Belongs to the actin-binding proteins ADF family. | 0.999 |
cdk-5 | act-5 | T27E9.3.1 | T25C8.2.2 | Cyclin-dependent-like kinase 5; Proline-directed serine/threonine-protein kinase which, in several motor neurons, promotes the polarized trafficking of synaptic vesicles and dense-core vesicles (DCV). In the ventral nerve cord, phosphorylates lin-10 and thereby prevents lin-10-mediated anterograde trafficking of the glutamate receptor glr-1. Involved in the inhibition of glr-1 trafficking in hypoxic conditions. In DA motor neurons but not in DB motor neurons, regulates axonal transport of synaptic vesicle precursors by inhibiting dynein-mediated retrograde transport. Regulates the traf [...] | ACTin. | 0.820 |
cdk-5 | rho-1 | T27E9.3.1 | Y51H4A.3a.1 | Cyclin-dependent-like kinase 5; Proline-directed serine/threonine-protein kinase which, in several motor neurons, promotes the polarized trafficking of synaptic vesicles and dense-core vesicles (DCV). In the ventral nerve cord, phosphorylates lin-10 and thereby prevents lin-10-mediated anterograde trafficking of the glutamate receptor glr-1. Involved in the inhibition of glr-1 trafficking in hypoxic conditions. In DA motor neurons but not in DB motor neurons, regulates axonal transport of synaptic vesicle precursors by inhibiting dynein-mediated retrograde transport. Regulates the traf [...] | Ras-like GTP-binding protein rhoA; Required for ventral migration of epidermal cells during ventral enclosure in the embryo and for cell elongation. Also required for ventral migration of P cells during larval development. Involved in asymmetric spindle positioning during anaphase and establishment of cell polarity during embryo development. In adults, involved in regulation of multiple processes including locomotion, pharyngeal pumping, fecundity, ovulation, defecation and body morphology. In body wall muscles, regulates organization of myosin thick filaments downstream of unc-89. Ass [...] | 0.701 |
cdk-5 | snt-3 | T27E9.3.1 | Y75B7AL.3.1 | Cyclin-dependent-like kinase 5; Proline-directed serine/threonine-protein kinase which, in several motor neurons, promotes the polarized trafficking of synaptic vesicles and dense-core vesicles (DCV). In the ventral nerve cord, phosphorylates lin-10 and thereby prevents lin-10-mediated anterograde trafficking of the glutamate receptor glr-1. Involved in the inhibition of glr-1 trafficking in hypoxic conditions. In DA motor neurons but not in DB motor neurons, regulates axonal transport of synaptic vesicle precursors by inhibiting dynein-mediated retrograde transport. Regulates the traf [...] | SyNapTotagmin. | 0.425 |
cdk-5 | snt-5 | T27E9.3.1 | R12A1.2a.1 | Cyclin-dependent-like kinase 5; Proline-directed serine/threonine-protein kinase which, in several motor neurons, promotes the polarized trafficking of synaptic vesicles and dense-core vesicles (DCV). In the ventral nerve cord, phosphorylates lin-10 and thereby prevents lin-10-mediated anterograde trafficking of the glutamate receptor glr-1. Involved in the inhibition of glr-1 trafficking in hypoxic conditions. In DA motor neurons but not in DB motor neurons, regulates axonal transport of synaptic vesicle precursors by inhibiting dynein-mediated retrograde transport. Regulates the traf [...] | SyNapTotagmin. | 0.408 |
cdk-5 | snt-6 | T27E9.3.1 | C08G5.4a.1 | Cyclin-dependent-like kinase 5; Proline-directed serine/threonine-protein kinase which, in several motor neurons, promotes the polarized trafficking of synaptic vesicles and dense-core vesicles (DCV). In the ventral nerve cord, phosphorylates lin-10 and thereby prevents lin-10-mediated anterograde trafficking of the glutamate receptor glr-1. Involved in the inhibition of glr-1 trafficking in hypoxic conditions. In DA motor neurons but not in DB motor neurons, regulates axonal transport of synaptic vesicle precursors by inhibiting dynein-mediated retrograde transport. Regulates the traf [...] | C2 domain-containing protein. | 0.424 |
cdk-5 | snt-7 | T27E9.3.1 | T10B10.5.1 | Cyclin-dependent-like kinase 5; Proline-directed serine/threonine-protein kinase which, in several motor neurons, promotes the polarized trafficking of synaptic vesicles and dense-core vesicles (DCV). In the ventral nerve cord, phosphorylates lin-10 and thereby prevents lin-10-mediated anterograde trafficking of the glutamate receptor glr-1. Involved in the inhibition of glr-1 trafficking in hypoxic conditions. In DA motor neurons but not in DB motor neurons, regulates axonal transport of synaptic vesicle precursors by inhibiting dynein-mediated retrograde transport. Regulates the traf [...] | C2 domain-containing protein. | 0.405 |