STRINGSTRING
his-47 his-47 nhr-10 nhr-10 nhr-28 nhr-28 acdh-2 acdh-2 acdh-1 acdh-1 din-1 din-1 fat-7 fat-7 daf-12 daf-12 nhr-178 nhr-178 nhr-45 nhr-45 nhr-80 nhr-80 nhr-49 nhr-49 unc-119 unc-119 nhr-12 nhr-12 mdt-15 mdt-15 rol-6 rol-6 nhr-102 nhr-102 his-3 his-3 nhr-273 nhr-273 nhr-109 nhr-109 med-1 med-1 nhr-79 nhr-79 nhr-41 nhr-41 nhr-234 nhr-234 nhr-86 nhr-86 sbp-1 sbp-1 nhr-70 nhr-70
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
his-47Histone H2A; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (127 aa)
nhr-10Nuclear hormone receptor family member nhr-10; Orphan nuclear receptor; Belongs to the nuclear hormone receptor family. (395 aa)
nhr-28Nuclear hormone receptor family member nhr-28; Orphan nuclear receptor; Belongs to the nuclear hormone receptor family. (437 aa)
acdh-2Acyl CoA DeHydrogenase. (386 aa)
acdh-1Acyl CoA DeHydrogenase. (427 aa)
din-1Daf-12-interacting protein 1; [Isoform d]: Probable transcriptional corepressor which modulates activity of the nuclear hormone receptor daf-12 to regulate the dauer diapause. (2407 aa)
fat-7Delta(9)-fatty-acid desaturase fat-7; Delta(9)-fatty-acid desaturase that acts preferentially on stearoyl-CoA. Also acts on vaccenyl-coA, heptadecanyol-CoA, and palmitoyl-CoA. (338 aa)
daf-12Nuclear hormone receptor family member daf-12; Nuclear receptor which binds directly to response elements in target gene promoters. Activity is modulated by binding of steroid hormone ligands that include dafachronic acids. Regulates expression of genes involved in postembryonic development and the dauer diapause, in response to environmental cues. Inhibits the expression of let-7 family members when bound to corepressor din-1s which is an isoform of din-1. Has a role in the immune response to bacterial infection, via regulation of let-7 miRNAs. Controls expression of genes that promot [...] (753 aa)
nhr-178Nuclear Hormone Receptor family. (421 aa)
nhr-45Nuclear Hormone Receptor family. (525 aa)
nhr-80Nuclear Hormone Receptor family. (504 aa)
nhr-49Nuclear hormone receptor family member nhr-49; Orphan nuclear receptor. Regulates expression of lipid desaturase, fat-7 ; Belongs to the nuclear hormone receptor family. (501 aa)
unc-119Protein unc-119; Myristoyl-binding protein that acts as a cargo adapter: specifically binds the myristoyl moiety of a subset of N-terminally myristoylated proteins and is required for their localization. Plays a key role in ciliary membrane localization of proteins. Required for the establishment or function of the nervous system. (244 aa)
nhr-12Nuclear hormone receptor family member nhr-12; Orphan nuclear receptor; Belongs to the nuclear hormone receptor family. (456 aa)
mdt-15Mediator of RNA polymerase II transcription subunit 15; Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Require [...] (780 aa)
rol-6Cuticle collagen rol-6; Nematode cuticles are composed largely of collagen-like proteins. The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment. Involved in body morphogenesis. (348 aa)
nhr-102Nuclear Hormone Receptor family. (414 aa)
his-3Histone H2A. (127 aa)
nhr-273Nuclear Hormone Receptor family. (378 aa)
nhr-109NR LBD domain-containing protein. (367 aa)
med-1GATA-type domain-containing protein. (174 aa)
nhr-79Nuclear hormone receptor family member nhr-79; Orphan nuclear receptor; Belongs to the nuclear hormone receptor family. (463 aa)
nhr-41Nuclear hormone receptor family member nhr-41; Orphan nuclear receptor that may have a role in dauer formation; Belongs to the nuclear hormone receptor family. (657 aa)
nhr-234Nuclear Hormone Receptor family; Belongs to the nuclear hormone receptor family. (357 aa)
nhr-86Nuclear hormone receptor family member nhr-86; Orphan nuclear receptor; Belongs to the nuclear hormone receptor family. (407 aa)
sbp-1BHLH domain-containing protein. (1113 aa)
nhr-70Nuclear Hormone Receptor family. (389 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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