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ced-9 ced-9 atg-7 atg-7 gln-2 gln-2 ant-1.3 ant-1.3 malt-1 malt-1 lgg-3 lgg-3 atg-5 atg-5 atg-3 atg-3 ant-1.2 ant-1.2 ant-1.1 ant-1.1 pygl-1 pygl-1 ant-1.4 ant-1.4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ced-9Apoptosis regulator ced-9; Plays a major role in programmed cell death (PCD, apoptosis). egl-1 binds to and directly inhibits the activity of ced-9, releasing the cell death activator ced-4 from a ced-9/ced-4 containing protein complex and allowing ced-4 to activate the cell-killing caspase ced-3. During larval development, required for the elimination of transient presynaptic components downstream of egl-1 and upstream of ced-4 and ced-3 apoptotic pathway. (280 aa)
atg-7Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for autophagy. (647 aa)
gln-2Probable glutamine synthetase. (367 aa)
ant-1.3Mitochondrial adenine nucleotide translocase 1.3; Belongs to the mitochondrial carrier (TC 2.A.29) family. (313 aa)
malt-1MALT1 paracaspase homolog. (639 aa)
lgg-3Ubiquitin-like protein atg-12; Ubiquitin-like protein involved in autophagy vesicles formation (By similarity). Conjugation with atg-5 through a ubiquitin- like conjugating system involving also atg-7 as an E1-like activating enzyme and atg-10 as an E2-like conjugating enzyme, is essential for its function (By similarity). Most likely a component of an atg-5-lgg- 3-atg-16 complex that promotes autophagosome formation by associating with lgg-2, but not lgg-1, at the preautophagosomal membrane. Probably, as part of an atg-5-lgg- 3-atg-16 complex, required for lgg-1 lipidation; the comple [...] (118 aa)
atg-5Autophagy-related protein 5; Involved in autophagic vesicle formation (By similarity). Conjugation with lgg-3/ATG12, through a ubiquitin-like conjugating system involving atg-7 as an E1-like activating enzyme and atg-10 as an E2-like conjugating enzyme, is essential for its function (By similarity). Most likely a component of an atg-5-lgg-3-atg-16 complex that promotes autophagosome formation by associating with lgg-2, but not lgg-1, at the preautophagosomal membrane. Probably, as part of an atg-5-lgg-3-atg-16 complex, required for lgg-1 lipidation; the complex acts as an E3-like enzym [...] (275 aa)
atg-3Autophagy-related protein 3. (305 aa)
ant-1.2Adenine Nucleotide Translocator; Belongs to the mitochondrial carrier (TC 2.A.29) family. (300 aa)
ant-1.1Adenine Nucleotide Translocator; Belongs to the mitochondrial carrier (TC 2.A.29) family. (300 aa)
pygl-1Alpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (882 aa)
ant-1.4Mitochondrial adenine nucleotide translocase 1.4; Belongs to the mitochondrial carrier (TC 2.A.29) family. (313 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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