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lite-1 lite-1 unc-103 unc-103 lev-8 lev-8 inx-14 inx-14 lev-1 lev-1 egl-2 egl-2 unc-38 unc-38 inx-3 inx-3 acr-16 acr-16 acr-18 acr-18 unc-64 unc-64 gpd-3 gpd-3 gpd-2 gpd-2 vglu-2 vglu-2 unc-68 unc-68 unc-9 unc-9 unc-29 unc-29 inx-11 inx-11 lev-11 lev-11 unc-63 unc-63 gar-3 gar-3 pha-1 pha-1 acr-8 acr-8 eat-4 eat-4 inx-8 inx-8 inx-9 inx-9
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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lite-1High-energy light unresponsive protein 1; Photoreceptor for short wavelength (UV) light that mediates UV-light-induced avoidance behavior. Directly senses and absorbs both UV-A and UV-B light with very high efficiency. Absorption of UV-B but not UV-A light shows resistance to photobleaching. In contrast to other photoreceptors, does not use a prosthetic chromophore to capture photons and only depends on its protein conformation. (439 aa)
unc-103Potassium voltage-gated channel unc-103; Pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. Channel properties are modulated by cAMP and subunit assembly (By similarity). Regulates the movements of the male's copulatory spicules before and during male mating behavior ; Belongs to the potassium channel family. H (Eag) (TC 1.A.1.20) subfamily. Kv11.1/KCNH2 sub-subfamily. (898 aa)
lev-8Uncharacterized protein. (531 aa)
inx-14Innexin-14; Structural component of the gap junctions. (434 aa)
lev-1Acetylcholine receptor subunit beta-type lev-1; Non-alpha subunit of nicotinic acetylcholine receptor (nAChR). Involved in nAChR sensitivity to nicotine. Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. (507 aa)
egl-2Uncharacterized protein. (959 aa)
unc-38Acetylcholine receptor subunit alpha-type unc-38; Alpha subunit of nicotinic acetylcholine receptor (nAChR). Probably acts in cholinergic motoneurons to regulate presynaptic neurotransmitter release, thereby ensuring normal level of excitation of cholinergic motoneurons during locomotion. Involved in nAChR sensitivity to nicotine. Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. (511 aa)
inx-3Innexin-3; Structural component of the gap junctions. Belongs to the pannexin family. (420 aa)
acr-16Acetylcholine receptor subunit alpha-type acr-16; After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane (By similarity). A subunit of the levamisole-insensitive nicotinic receptor. (498 aa)
acr-18AcetylCholine Receptor; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (510 aa)
unc-64Syntaxin-1A homolog; Plays a critical role in several secretory processes, including cuticle secretion and neurotransmitter release, and probably assists in neuronal membrane maturation or the final stages of neuronal differentiation. Essential for embryonic viability and development. Has a role in dauer formation and adult life span. Required for locomotion. Probably by regulating neuronal transmission downstream of lin-3 and receptor lin-23 and phospholipase plc-3 and upstream of innexin unc-7 and egl-4/PKG in ALA neurons, involved in the decrease in pharyngeal pumping during the qui [...] (291 aa)
gpd-3Glyceraldehyde-3-phosphate dehydrogenase 3. (341 aa)
gpd-2Glyceraldehyde-3-phosphate dehydrogenase 2. (341 aa)
vglu-2MFS domain-containing protein. (573 aa)
unc-68Uncharacterized protein. (5202 aa)
unc-9Innexin unc-9; Structural component of the gap junctions. Belongs to the pannexin family. (386 aa)
unc-29Acetylcholine receptor subunit beta-type unc-29; Non-alpha subunit of nicotinic acetylcholine receptor (nAChR). Involved in nAChR sensitivity to nicotine and levasimole. Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. (493 aa)
inx-11Innexin-11; Structural component of the gap junctions. Belongs to the pannexin family. (529 aa)
lev-11Tropomyosin isoforms a/b/d/f; Tropomyosin, in association with the troponin complex, plays a central role in the calcium dependent regulation of muscle contraction. Involved in muscle actin filament organization and muscle arm extension and morphology. Protects actin filaments from depolymerization by unc-60 in vitro. Also has a role in male mating behavior by regulating the copulatory spicules. Binds to F-actin. (284 aa)
unc-63Acetylcholine receptor subunit alpha-type unc-63; Alpha subunit of nicotinic acetylcholine receptor (nAChR). Probably acts in cholinergic motoneurons to regulate presynaptic neurotransmitter release, thereby ensuring normal level of excitation of cholinergic motoneurons during locomotion. Involved in nAChR sensitivity to nicotine and levamisole. (502 aa)
gar-3Muscarinic acetylcholine receptor gar-3; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover (By similarity). Enhances the release of the neurotransmitter acetlycholine in cholinergic motor neurons, which in turn positively feeds back to depolarize body wall muscles and allows for the maintenance of normal body posture and locomotion. (611 aa)
pha-1Pha-1 protein. (491 aa)
acr-8Acetylcholine receptor 8. (537 aa)
eat-4Probable vesicular glutamate transporter eat-4; Required for glutamatergic synaptic transmission. In AWB and AWC sensory neurons, required for the detection of preferred food sources, probably via glutamatergic neurotransmission from sensory neurons. Negatively regulates the turning step of male mating behavior. (576 aa)
inx-8Innexin-8; Structural component of the gap junctions. Belongs to the pannexin family. (382 aa)
inx-9Innexin; Structural component of the gap junctions. Belongs to the pannexin family. (382 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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