28 items (Caenorhabditis elegans) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	air-2	Aurora/IPL1-related protein kinase 2; Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of chromosome segregation and cytokinesis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation. Required for histone H3 phosphorylation during segregation of homologous chromosomes in meiosis and mitosis. Required for histone H3 'Ser- 10' phosphorylation. Phosphorylates tlk-1 at 'Ser-634', which enhances its activity. Phosphorylates zen-4 at 'Ser- 680'. Required f [...] (305 aa)
	swsn-9	Bromo domain-containing protein. (636 aa)
	tsg-101	Tumor Susceptibility Gene homolog. (425 aa)
	C13F10.7	Uncharacterized protein. (222 aa)
	ccdc-55	Nuclear speckle splicing regulatory protein 1 homolog; Required for the cessation of distal tip cell migration at the end of larval morphogenesis; Belongs to the NSRP1 family. (392 aa)
	klc-2	Kinesin light chain; Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport (Probable). The light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity (Probable). Recruits unc-83 (within the unc-83-unc-84 LINC complex) to the nuclear envelope during nuclear migration to mediate the link between the nuclear envelope and the microtubule cytoskeleton in hypodermal precursor cells. (540 aa)
	pas-4	Proteasome subunit alpha type-7; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. (253 aa)
	vps-37	VPS37 C-terminal domain-containing protein. (234 aa)
	asb-2	ATP Synthase B homolog. (305 aa)
	hmgr-1	3-hydroxy-3-methylglutaryl coenzyme A reductase. (550 aa)
	sdhd-1	Putative succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial; Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). (145 aa)
	rps-9	40S ribosomal protein S9; Belongs to the universal ribosomal protein uS4 family. (189 aa)
	anmt-2	Amine N-MethylTransferase. (274 aa)
	F42C5.9	PH domain-containing protein; Belongs to the actin family. (552 aa)
	F53E10.6	RRP15-like protein; Belongs to the RRP15 family. (191 aa)
	F54D5.9	F-box domain-containing protein. (565 aa)
	nhl-1	RING finger protein nhl-1. (974 aa)
	K04G7.1	Integrase_H2C2 domain-containing protein. (558 aa)
	lpd-6	Brix domain-containing protein. (573 aa)
	tag-260	IRF-2BP1_2 domain-containing protein. (457 aa)
	act-3	Actin-1; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. (376 aa)
	act-1	Actin-1. (376 aa)
	act-5	ACTin. (375 aa)
	vps-24	Related to yeast Vacuolar Protein Sorting factor. (208 aa)
	cox-4	Cytochrome OXidase assembly protein. (175 aa)
	lec-1	32 kDa beta-galactoside-binding lectin; Binds galactose. (285 aa)
	comt-3	Catechol-O-MethylTransferase family. (226 aa)
	eif-2Bbeta	Eukaryotic Initiation Factor; Belongs to the eIF-2B alpha/beta/delta subunits family. (340 aa)

Your Current Organism:

Caenorhabditis elegans

NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
C13F10.7	F53E10.6	C13F10.7.2	F53E10.6.1	Uncharacterized protein.	RRP15-like protein; Belongs to the RRP15 family.	0.802
C13F10.7	F54D5.9	C13F10.7.2	F54D5.9.1	Uncharacterized protein.	F-box domain-containing protein.	0.769
C13F10.7	K04G7.1	C13F10.7.2	K04G7.1.2	Uncharacterized protein.	Integrase_H2C2 domain-containing protein.	0.815
C13F10.7	anmt-2	C13F10.7.2	F42A10.3.1	Uncharacterized protein.	Amine N-MethylTransferase.	0.760
C13F10.7	ccdc-55	C13F10.7.2	C16C10.6.1	Uncharacterized protein.	Nuclear speckle splicing regulatory protein 1 homolog; Required for the cessation of distal tip cell migration at the end of larval morphogenesis; Belongs to the NSRP1 family.	0.703
C13F10.7	comt-3	C13F10.7.2	Y40B10A.2a.1	Uncharacterized protein.	Catechol-O-MethylTransferase family.	0.660
C13F10.7	eif-2Bbeta	C13F10.7.2	Y47H9C.7.1	Uncharacterized protein.	Eukaryotic Initiation Factor; Belongs to the eIF-2B alpha/beta/delta subunits family.	0.667
C13F10.7	lec-1	C13F10.7.2	W09H1.6b.2	Uncharacterized protein.	32 kDa beta-galactoside-binding lectin; Binds galactose.	0.461
C13F10.7	lpd-6	C13F10.7.2	K09H9.6.1	Uncharacterized protein.	Brix domain-containing protein.	0.759
C13F10.7	rps-9	C13F10.7.2	F40F8.10.1	Uncharacterized protein.	40S ribosomal protein S9; Belongs to the universal ribosomal protein uS4 family.	0.463
C13F10.7	sdhd-1	C13F10.7.2	F33A8.5.1	Uncharacterized protein.	Putative succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial; Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).	0.450
C13F10.7	tag-260	C13F10.7.2	M04G12.1a.1	Uncharacterized protein.	IRF-2BP1_2 domain-containing protein.	0.698
C13F10.7	vps-24	C13F10.7.2	T27F7.1.2	Uncharacterized protein.	Related to yeast Vacuolar Protein Sorting factor.	0.400
F42C5.9	F53E10.6	F42C5.9.2	F53E10.6.1	PH domain-containing protein; Belongs to the actin family.	RRP15-like protein; Belongs to the RRP15 family.	0.465
F42C5.9	F54D5.9	F42C5.9.2	F54D5.9.1	PH domain-containing protein; Belongs to the actin family.	F-box domain-containing protein.	0.465
F42C5.9	K04G7.1	F42C5.9.2	K04G7.1.2	PH domain-containing protein; Belongs to the actin family.	Integrase_H2C2 domain-containing protein.	0.401
F42C5.9	anmt-2	F42C5.9.2	F42A10.3.1	PH domain-containing protein; Belongs to the actin family.	Amine N-MethylTransferase.	0.443
F42C5.9	lpd-6	F42C5.9.2	K09H9.6.1	PH domain-containing protein; Belongs to the actin family.	Brix domain-containing protein.	0.466
F42C5.9	nhl-1	F42C5.9.2	F54G8.4a.1	PH domain-containing protein; Belongs to the actin family.	RING finger protein nhl-1.	0.806
F42C5.9	swsn-9	F42C5.9.2	C01H6.7a.3	PH domain-containing protein; Belongs to the actin family.	Bromo domain-containing protein.	0.462