STRINGSTRING
eif-2alpha eif-2alpha ZK970.8 ZK970.8 rpb-7 rpb-7 hsp-70 hsp-70 hsp-90 hsp-90 ptp-1 ptp-1 hxk-1 hxk-1 rpb-4 rpb-4 F43G6.5 F43G6.5 pek-1 pek-1 gcn-2 gcn-2 xbp-1 xbp-1 T15H9.6 T15H9.6 pap-1 pap-1 Y95B8A.8 Y95B8A.8
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
eif-2alphaS1 motif domain-containing protein. (342 aa)
ZK970.8Uncharacterized protein. (143 aa)
rpb-7S1 motif domain-containing protein. (197 aa)
hsp-70Heat Shock Protein; Belongs to the heat shock protein 70 family. (643 aa)
hsp-90Heat shock protein 90; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co- chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. By stabilizing the receptor-type guanylate cyclase daf-11 or another sig [...] (702 aa)
ptp-1Tyrosine-protein phosphatase 1. (1026 aa)
hxk-1Phosphotransferase; Belongs to the hexokinase family. (500 aa)
rpb-4RPOL4c domain-containing protein. (144 aa)
F43G6.5Poly(A) polymerase; Polymerase that creates the 3'-poly(A) tail of mRNA's. (554 aa)
pek-1Eukaryotic translation initiation factor 2-alpha kinase pek-1; Phosphorylates the alpha subunit of eukaryotic translation- initiation factor 2 (eIF2alpha), leading to its inactivation and thus to a rapid reduction of translational initiation and repression of global protein synthesis. May phosphorylate eIF2alpha during hypoxia. Proposed to have a role in alleviating endoplasmic reticulum stress ; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily. (1077 aa)
gcn-2Eukaryotic translation initiation factor 2-alpha kinase gcn-2; Serine/threonine-protein kinase which phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (eIF2alpha), leading to its inactivation and thus to a rapid reduction of translational initiation and repression of global protein synthesis (By similarity). Involved in the unfolded protein response (UPR) triggered by several stresses including mitochondrial, osmotic and oxidative stresses, amino acid deprivation and UV irradiation, probably by phosphorylating and inhibiting eIF2alpha. In addition, leads to [...] (1699 aa)
xbp-1BZIP domain-containing protein. (335 aa)
T15H9.6Poly(A) polymerase; Polymerase that creates the 3'-poly(A) tail of mRNA's. (554 aa)
pap-1Poly(A) polymerase; Polymerase that creates the 3'-poly(A) tail of mRNA's. (655 aa)
Y95B8A.8DZF domain-containing protein. (764 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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