node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
F43G6.5 | T15H9.6 | F43G6.5.1 | T15H9.6.1 | Poly(A) polymerase; Polymerase that creates the 3'-poly(A) tail of mRNA's. | Poly(A) polymerase; Polymerase that creates the 3'-poly(A) tail of mRNA's. | 0.984 |
F43G6.5 | pap-1 | F43G6.5.1 | Y32F6A.3.1 | Poly(A) polymerase; Polymerase that creates the 3'-poly(A) tail of mRNA's. | Poly(A) polymerase; Polymerase that creates the 3'-poly(A) tail of mRNA's. | 0.904 |
T15H9.6 | F43G6.5 | T15H9.6.1 | F43G6.5.1 | Poly(A) polymerase; Polymerase that creates the 3'-poly(A) tail of mRNA's. | Poly(A) polymerase; Polymerase that creates the 3'-poly(A) tail of mRNA's. | 0.984 |
T15H9.6 | pap-1 | T15H9.6.1 | Y32F6A.3.1 | Poly(A) polymerase; Polymerase that creates the 3'-poly(A) tail of mRNA's. | Poly(A) polymerase; Polymerase that creates the 3'-poly(A) tail of mRNA's. | 0.905 |
Y95B8A.8 | ptp-1 | Y95B8A.8.1 | C48D5.2a.2 | DZF domain-containing protein. | Tyrosine-protein phosphatase 1. | 0.528 |
Y95B8A.8 | rpb-4 | Y95B8A.8.1 | F43E2.2.1 | DZF domain-containing protein. | RPOL4c domain-containing protein. | 0.482 |
ZK970.8 | eif-2alpha | ZK970.8.1 | Y37E3.10a.1 | Uncharacterized protein. | S1 motif domain-containing protein. | 0.566 |
ZK970.8 | gcn-2 | ZK970.8.1 | Y81G3A.3b.1 | Uncharacterized protein. | Eukaryotic translation initiation factor 2-alpha kinase gcn-2; Serine/threonine-protein kinase which phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (eIF2alpha), leading to its inactivation and thus to a rapid reduction of translational initiation and repression of global protein synthesis (By similarity). Involved in the unfolded protein response (UPR) triggered by several stresses including mitochondrial, osmotic and oxidative stresses, amino acid deprivation and UV irradiation, probably by phosphorylating and inhibiting eIF2alpha. In addition, leads to [...] | 0.800 |
eif-2alpha | ZK970.8 | Y37E3.10a.1 | ZK970.8.1 | S1 motif domain-containing protein. | Uncharacterized protein. | 0.566 |
eif-2alpha | gcn-2 | Y37E3.10a.1 | Y81G3A.3b.1 | S1 motif domain-containing protein. | Eukaryotic translation initiation factor 2-alpha kinase gcn-2; Serine/threonine-protein kinase which phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (eIF2alpha), leading to its inactivation and thus to a rapid reduction of translational initiation and repression of global protein synthesis (By similarity). Involved in the unfolded protein response (UPR) triggered by several stresses including mitochondrial, osmotic and oxidative stresses, amino acid deprivation and UV irradiation, probably by phosphorylating and inhibiting eIF2alpha. In addition, leads to [...] | 0.999 |
eif-2alpha | hsp-70 | Y37E3.10a.1 | C12C8.1.1 | S1 motif domain-containing protein. | Heat Shock Protein; Belongs to the heat shock protein 70 family. | 0.646 |
eif-2alpha | hsp-90 | Y37E3.10a.1 | C47E8.5.3 | S1 motif domain-containing protein. | Heat shock protein 90; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co- chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. By stabilizing the receptor-type guanylate cyclase daf-11 or another sig [...] | 0.607 |
eif-2alpha | pek-1 | Y37E3.10a.1 | F46C3.1.1 | S1 motif domain-containing protein. | Eukaryotic translation initiation factor 2-alpha kinase pek-1; Phosphorylates the alpha subunit of eukaryotic translation- initiation factor 2 (eIF2alpha), leading to its inactivation and thus to a rapid reduction of translational initiation and repression of global protein synthesis. May phosphorylate eIF2alpha during hypoxia. Proposed to have a role in alleviating endoplasmic reticulum stress ; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily. | 0.999 |
eif-2alpha | xbp-1 | Y37E3.10a.1 | R74.3a.1 | S1 motif domain-containing protein. | BZIP domain-containing protein. | 0.908 |
gcn-2 | ZK970.8 | Y81G3A.3b.1 | ZK970.8.1 | Eukaryotic translation initiation factor 2-alpha kinase gcn-2; Serine/threonine-protein kinase which phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (eIF2alpha), leading to its inactivation and thus to a rapid reduction of translational initiation and repression of global protein synthesis (By similarity). Involved in the unfolded protein response (UPR) triggered by several stresses including mitochondrial, osmotic and oxidative stresses, amino acid deprivation and UV irradiation, probably by phosphorylating and inhibiting eIF2alpha. In addition, leads to [...] | Uncharacterized protein. | 0.800 |
gcn-2 | eif-2alpha | Y81G3A.3b.1 | Y37E3.10a.1 | Eukaryotic translation initiation factor 2-alpha kinase gcn-2; Serine/threonine-protein kinase which phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (eIF2alpha), leading to its inactivation and thus to a rapid reduction of translational initiation and repression of global protein synthesis (By similarity). Involved in the unfolded protein response (UPR) triggered by several stresses including mitochondrial, osmotic and oxidative stresses, amino acid deprivation and UV irradiation, probably by phosphorylating and inhibiting eIF2alpha. In addition, leads to [...] | S1 motif domain-containing protein. | 0.999 |
gcn-2 | hsp-70 | Y81G3A.3b.1 | C12C8.1.1 | Eukaryotic translation initiation factor 2-alpha kinase gcn-2; Serine/threonine-protein kinase which phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (eIF2alpha), leading to its inactivation and thus to a rapid reduction of translational initiation and repression of global protein synthesis (By similarity). Involved in the unfolded protein response (UPR) triggered by several stresses including mitochondrial, osmotic and oxidative stresses, amino acid deprivation and UV irradiation, probably by phosphorylating and inhibiting eIF2alpha. In addition, leads to [...] | Heat Shock Protein; Belongs to the heat shock protein 70 family. | 0.701 |
gcn-2 | hsp-90 | Y81G3A.3b.1 | C47E8.5.3 | Eukaryotic translation initiation factor 2-alpha kinase gcn-2; Serine/threonine-protein kinase which phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (eIF2alpha), leading to its inactivation and thus to a rapid reduction of translational initiation and repression of global protein synthesis (By similarity). Involved in the unfolded protein response (UPR) triggered by several stresses including mitochondrial, osmotic and oxidative stresses, amino acid deprivation and UV irradiation, probably by phosphorylating and inhibiting eIF2alpha. In addition, leads to [...] | Heat shock protein 90; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co- chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. By stabilizing the receptor-type guanylate cyclase daf-11 or another sig [...] | 0.617 |
gcn-2 | pek-1 | Y81G3A.3b.1 | F46C3.1.1 | Eukaryotic translation initiation factor 2-alpha kinase gcn-2; Serine/threonine-protein kinase which phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (eIF2alpha), leading to its inactivation and thus to a rapid reduction of translational initiation and repression of global protein synthesis (By similarity). Involved in the unfolded protein response (UPR) triggered by several stresses including mitochondrial, osmotic and oxidative stresses, amino acid deprivation and UV irradiation, probably by phosphorylating and inhibiting eIF2alpha. In addition, leads to [...] | Eukaryotic translation initiation factor 2-alpha kinase pek-1; Phosphorylates the alpha subunit of eukaryotic translation- initiation factor 2 (eIF2alpha), leading to its inactivation and thus to a rapid reduction of translational initiation and repression of global protein synthesis. May phosphorylate eIF2alpha during hypoxia. Proposed to have a role in alleviating endoplasmic reticulum stress ; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily. | 0.950 |
gcn-2 | xbp-1 | Y81G3A.3b.1 | R74.3a.1 | Eukaryotic translation initiation factor 2-alpha kinase gcn-2; Serine/threonine-protein kinase which phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (eIF2alpha), leading to its inactivation and thus to a rapid reduction of translational initiation and repression of global protein synthesis (By similarity). Involved in the unfolded protein response (UPR) triggered by several stresses including mitochondrial, osmotic and oxidative stresses, amino acid deprivation and UV irradiation, probably by phosphorylating and inhibiting eIF2alpha. In addition, leads to [...] | BZIP domain-containing protein. | 0.862 |