STRINGSTRING
hsp-70 hsp-70 hsp-90 hsp-90 alh-10 alh-10 alh-11 alh-11 alh-7 alh-7 alh-1 alh-1 alh-6 alh-6 alh-2 alh-2 daf-16 daf-16 alh-4 alh-4 alh-5 alh-5 gst-10 gst-10 alh-12 alh-12
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
hsp-70Heat Shock Protein; Belongs to the heat shock protein 70 family. (643 aa)
hsp-90Heat shock protein 90; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co- chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. By stabilizing the receptor-type guanylate cyclase daf-11 or another sig [...] (702 aa)
alh-10Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family. (506 aa)
alh-11Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family. (687 aa)
alh-7Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family. (493 aa)
alh-1Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family. (510 aa)
alh-6Delta-1-pyrroline-5-carboxylate dehydrogenase; Belongs to the aldehyde dehydrogenase family. (563 aa)
alh-2Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family. (514 aa)
daf-16Forkhead box protein O; Forkhead-type transcription factor. Binds to the promoters of genes that contain the daf-16 binding element (DBE), TTGTTTAC, in their regulatory region. Functions in the Insulin/IGF-1-like signaling (IIS) mediated pathway which affects lipogenesis, lifespan, starvation survival, heat shock and oxidative stress responses, and dauer formation. Longevity signaling predominantly arises from expression in the intestine. Daf-16 transcriptional activity is negatively regulated by cytoplasmic sequestration by association with ftt-2. Inhibition is required for the carbon [...] (541 aa)
alh-4Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (494 aa)
alh-5Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (437 aa)
gst-10Glutathione S-transferase P 10; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Responsible for approximately one-third of 4-hydroxy-2-nonenal conjugation (Ref.1,. May play a role in the detoxification of reactive oxygen species produced during pathogenic bacterial infection. Belongs to the GST superfamily. Pi family. (210 aa)
alh-12Aldedh domain-containing protein. (499 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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