STRINGSTRING
acy-2 acy-2 acy-3 acy-3 acy-1 acy-1 nphp-1 nphp-1 jamp-1 jamp-1 bbs-5 bbs-5 nphp-4 nphp-4 ptc-3 ptc-3 ift-139 ift-139 ift-20 ift-20 ptc-1 ptc-1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
acy-2Adenylyl CYclase; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1080 aa)
acy-3Adenylyl CYclase. (1243 aa)
acy-1Adenylyl CYclase. (1253 aa)
nphp-1Nephrocystin-1-like protein; May be necessary for initial assembly of the cilium. (682 aa)
jamp-1JAMP (JNK1-Associated Membrane Protein) homolog. (326 aa)
bbs-5Bardet-Biedl syndrome 5 protein homolog; Component of the BBSome complex (By similarity). The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia (By similarity). The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function (By similarity). Required for BBSome complex ciliary localization but not for the proper complex assembly (By similarity). Required, redundantly with bbs-4, for cilia biogenesis and both the assembly and movement of intraflagellar transport proteins al [...] (361 aa)
nphp-4NePHronoPhthisis (Human kidney disease) homolog. (1305 aa)
ptc-3Protein patched homolog 3; Regulates osmosis during embryonic development. Required for larval development and in particular is involved in larval molting. Belongs to the patched family. (1367 aa)
ift-139Tetratricopeptide repeat protein 21 homolog; Component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport. In particular, may act redundantly with the intraflagellar transport protein ift-43 to regulate the transport of specific ciliary cargo proteins such as che-3 which are related to motility. Functions in cilia biogenesis. Belongs to the TTC21 family. (1324 aa)
ift-20Intraflagellar transport protein 20 homolog; Component of the intraflagellar transport (IFT) complex B required for transport of proteins in the motile cilium. Required for ciliary entrance and transport of specific ciliary cargo proteins such as che-3 which are related to motility. (129 aa)
ptc-1Protein patched homolog 1; Required but not essential for cytokinesis of mitotically proliferating germ cells. (1408 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
Server load: low (18%) [HD]