node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
act-5 | deb-1 | T25C8.2.2 | ZC477.9d.1 | ACTin. | Vinculin; Involved in cell adhesion. May be involved in the attachment of the actin-based microfilaments to the plasma membrane. Involved in ovulation. | 0.998 |
act-5 | git-1 | T25C8.2.2 | F14F3.2.1 | ACTin. | GIT1 (Mammalian G protein-coupled receptor kinase InTeractor 1) homolog. | 0.621 |
act-5 | max-2 | T25C8.2.2 | Y38F1A.10e.1 | ACTin. | Serine/threonine-protein kinase max-2; Serine/threonine-protein kinase, which phosphorylates mlk-1. Involved in the stress response to heavy metals by activating the mlk- 1/mek-1/kgb-1 pathway. In ventral cord commissural motoneurons, required for dorsal axon guidance downstream of unc- 6/netrin repulsion receptor unc-5 and probably of Rho GTPases ced-10 and mig-2. Plays a redundant role with mig-10 in orientating axonal growth of HSN neurons. Plays a redundant role with pak-1 in P neuroblast migration and in distal tip cell (DTC)-mediated guidance of gonad elongation probably downstre [...] | 0.846 |
act-5 | pxl-1 | T25C8.2.2 | C28H8.6a.1 | ACTin. | Paxillin homolog 1; Required for myofilament organization of the pharyngeal sarcomeres and for pharyngeal muscle contractions and hence for pharyngeal pumping. Together with lin-8, might be required for myofilament organization in the body wall muscles ; Belongs to the paxillin family. | 0.981 |
act-5 | rho-1 | T25C8.2.2 | Y51H4A.3a.1 | ACTin. | Ras-like GTP-binding protein rhoA; Required for ventral migration of epidermal cells during ventral enclosure in the embryo and for cell elongation. Also required for ventral migration of P cells during larval development. Involved in asymmetric spindle positioning during anaphase and establishment of cell polarity during embryo development. In adults, involved in regulation of multiple processes including locomotion, pharyngeal pumping, fecundity, ovulation, defecation and body morphology. In body wall muscles, regulates organization of myosin thick filaments downstream of unc-89. Ass [...] | 0.989 |
act-5 | tln-1 | T25C8.2.2 | Y71G12B.11a.1 | ACTin. | Talin. | 0.991 |
act-5 | zyx-1 | T25C8.2.2 | F42G4.3e.2 | ACTin. | Zyxin; Functions as both a mechanical stabilizer (via LIM domains) of focal adhesions and as a sensor component for muscle cell damage (via N-terminus). Regulates, stabilizes and maintains posterior lateral mechanosensory (PLM) synaptic branch extension and new synapse formation and growth during larval development. | 0.902 |
deb-1 | act-5 | ZC477.9d.1 | T25C8.2.2 | Vinculin; Involved in cell adhesion. May be involved in the attachment of the actin-based microfilaments to the plasma membrane. Involved in ovulation. | ACTin. | 0.998 |
deb-1 | git-1 | ZC477.9d.1 | F14F3.2.1 | Vinculin; Involved in cell adhesion. May be involved in the attachment of the actin-based microfilaments to the plasma membrane. Involved in ovulation. | GIT1 (Mammalian G protein-coupled receptor kinase InTeractor 1) homolog. | 0.551 |
deb-1 | max-2 | ZC477.9d.1 | Y38F1A.10e.1 | Vinculin; Involved in cell adhesion. May be involved in the attachment of the actin-based microfilaments to the plasma membrane. Involved in ovulation. | Serine/threonine-protein kinase max-2; Serine/threonine-protein kinase, which phosphorylates mlk-1. Involved in the stress response to heavy metals by activating the mlk- 1/mek-1/kgb-1 pathway. In ventral cord commissural motoneurons, required for dorsal axon guidance downstream of unc- 6/netrin repulsion receptor unc-5 and probably of Rho GTPases ced-10 and mig-2. Plays a redundant role with mig-10 in orientating axonal growth of HSN neurons. Plays a redundant role with pak-1 in P neuroblast migration and in distal tip cell (DTC)-mediated guidance of gonad elongation probably downstre [...] | 0.432 |
deb-1 | pxl-1 | ZC477.9d.1 | C28H8.6a.1 | Vinculin; Involved in cell adhesion. May be involved in the attachment of the actin-based microfilaments to the plasma membrane. Involved in ovulation. | Paxillin homolog 1; Required for myofilament organization of the pharyngeal sarcomeres and for pharyngeal muscle contractions and hence for pharyngeal pumping. Together with lin-8, might be required for myofilament organization in the body wall muscles ; Belongs to the paxillin family. | 0.999 |
deb-1 | rho-1 | ZC477.9d.1 | Y51H4A.3a.1 | Vinculin; Involved in cell adhesion. May be involved in the attachment of the actin-based microfilaments to the plasma membrane. Involved in ovulation. | Ras-like GTP-binding protein rhoA; Required for ventral migration of epidermal cells during ventral enclosure in the embryo and for cell elongation. Also required for ventral migration of P cells during larval development. Involved in asymmetric spindle positioning during anaphase and establishment of cell polarity during embryo development. In adults, involved in regulation of multiple processes including locomotion, pharyngeal pumping, fecundity, ovulation, defecation and body morphology. In body wall muscles, regulates organization of myosin thick filaments downstream of unc-89. Ass [...] | 0.858 |
deb-1 | tln-1 | ZC477.9d.1 | Y71G12B.11a.1 | Vinculin; Involved in cell adhesion. May be involved in the attachment of the actin-based microfilaments to the plasma membrane. Involved in ovulation. | Talin. | 0.999 |
deb-1 | zyx-1 | ZC477.9d.1 | F42G4.3e.2 | Vinculin; Involved in cell adhesion. May be involved in the attachment of the actin-based microfilaments to the plasma membrane. Involved in ovulation. | Zyxin; Functions as both a mechanical stabilizer (via LIM domains) of focal adhesions and as a sensor component for muscle cell damage (via N-terminus). Regulates, stabilizes and maintains posterior lateral mechanosensory (PLM) synaptic branch extension and new synapse formation and growth during larval development. | 0.989 |
git-1 | act-5 | F14F3.2.1 | T25C8.2.2 | GIT1 (Mammalian G protein-coupled receptor kinase InTeractor 1) homolog. | ACTin. | 0.621 |
git-1 | deb-1 | F14F3.2.1 | ZC477.9d.1 | GIT1 (Mammalian G protein-coupled receptor kinase InTeractor 1) homolog. | Vinculin; Involved in cell adhesion. May be involved in the attachment of the actin-based microfilaments to the plasma membrane. Involved in ovulation. | 0.551 |
git-1 | grk-1 | F14F3.2.1 | F19C6.1.1 | GIT1 (Mammalian G protein-coupled receptor kinase InTeractor 1) homolog. | G protein-coupled receptor kinase 1; Specifically phosphorylates the activated forms of G protein- coupled receptors; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. | 0.924 |
git-1 | max-2 | F14F3.2.1 | Y38F1A.10e.1 | GIT1 (Mammalian G protein-coupled receptor kinase InTeractor 1) homolog. | Serine/threonine-protein kinase max-2; Serine/threonine-protein kinase, which phosphorylates mlk-1. Involved in the stress response to heavy metals by activating the mlk- 1/mek-1/kgb-1 pathway. In ventral cord commissural motoneurons, required for dorsal axon guidance downstream of unc- 6/netrin repulsion receptor unc-5 and probably of Rho GTPases ced-10 and mig-2. Plays a redundant role with mig-10 in orientating axonal growth of HSN neurons. Plays a redundant role with pak-1 in P neuroblast migration and in distal tip cell (DTC)-mediated guidance of gonad elongation probably downstre [...] | 0.950 |
git-1 | pxl-1 | F14F3.2.1 | C28H8.6a.1 | GIT1 (Mammalian G protein-coupled receptor kinase InTeractor 1) homolog. | Paxillin homolog 1; Required for myofilament organization of the pharyngeal sarcomeres and for pharyngeal muscle contractions and hence for pharyngeal pumping. Together with lin-8, might be required for myofilament organization in the body wall muscles ; Belongs to the paxillin family. | 0.985 |
git-1 | rho-1 | F14F3.2.1 | Y51H4A.3a.1 | GIT1 (Mammalian G protein-coupled receptor kinase InTeractor 1) homolog. | Ras-like GTP-binding protein rhoA; Required for ventral migration of epidermal cells during ventral enclosure in the embryo and for cell elongation. Also required for ventral migration of P cells during larval development. Involved in asymmetric spindle positioning during anaphase and establishment of cell polarity during embryo development. In adults, involved in regulation of multiple processes including locomotion, pharyngeal pumping, fecundity, ovulation, defecation and body morphology. In body wall muscles, regulates organization of myosin thick filaments downstream of unc-89. Ass [...] | 0.401 |