STRINGSTRING
cal-1 cal-1 fln-2 fln-2 ttx-3 ttx-3 myo-3 myo-3 spc-1 spc-1 K03A1.4 K03A1.4 cpn-4 cpn-4 mkk-4 mkk-4 cal-7 cal-7 cpn-3 cpn-3 unc-54 unc-54 cal-3 cal-3 vab-10 vab-10 deb-1 deb-1 tln-1 tln-1 fln-1 fln-1 rho-1 rho-1 atn-1 atn-1 act-5 act-5 cmd-1 cmd-1 cal-4 cal-4 cdc-42 cdc-42 B0563.7 B0563.7 cal-2 cal-2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
cal-1Calmodulin-like protein; This protein resembles calmodulin in sequence but possibly resembles troponin C in function. (180 aa)
fln-2FiLamiN (Actin binding protein) homolog. (3672 aa)
ttx-3LIM/homeobox protein ttx-3; Required for specification of the AIA and AIY interneurons and the NSM neurons. Positively regulates the expression of a number of genes including ceh-23, kal-1, hen-1, ser-2, unc-17 and sra-11 in AIY interneurons and cat-4, flp-4, bas-1, ptps-1 and mgl-1 in NSM neurons. Also acts in an autoregulatory feedback loop to maintain its own expression. Plays a role in the thermotactic response, olfactory imprinting, regulation of longevity, control of dauer formation and axon outgrowth and pathfinding. Not required for normal chemosensory behavior. (409 aa)
myo-3Myosin-3; Essential for muscle contraction. Involved in ovulation likely by regulating the contraction of gonadal myoepithelial sheath cells. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1969 aa)
spc-1SPeCtrin. (2432 aa)
K03A1.4EF-hand domain-containing protein. (184 aa)
cpn-4Calponin-homology (CH) domain-containing protein. (154 aa)
mkk-4MAP kinase kinase mkk-4; Activity is required in presynaptic neurons, in a dose- dependent manner, for normal presynaptic development and morphology. Plays a role in the formation of muscle connections, also called muscle arm extensions, between the body wall and the motor axons in the dorsal and ventral cord. (363 aa)
cal-7EF-hand domain-containing protein. (179 aa)
cpn-3Calponin-homology (CH) domain-containing protein. (142 aa)
unc-54Myosin-4; Required for muscle contraction. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1963 aa)
cal-3CALmodulin related genes. (234 aa)
vab-10GAR domain-containing protein. (5059 aa)
deb-1Vinculin; Involved in cell adhesion. May be involved in the attachment of the actin-based microfilaments to the plasma membrane. Involved in ovulation. (1090 aa)
tln-1Talin. (2553 aa)
fln-1Calponin-homology (CH) domain-containing protein. (2259 aa)
rho-1Ras-like GTP-binding protein rhoA; Required for ventral migration of epidermal cells during ventral enclosure in the embryo and for cell elongation. Also required for ventral migration of P cells during larval development. Involved in asymmetric spindle positioning during anaphase and establishment of cell polarity during embryo development. In adults, involved in regulation of multiple processes including locomotion, pharyngeal pumping, fecundity, ovulation, defecation and body morphology. In body wall muscles, regulates organization of myosin thick filaments downstream of unc-89. Ass [...] (192 aa)
atn-1AcTiniN. (920 aa)
act-5ACTin. (375 aa)
cmd-1Calmodulin; Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases. (149 aa)
cal-4CALmodulin related genes. (236 aa)
cdc-42Cell division control protein 42 homolog; Plays an essential role in spindle orientation and organizing cellular and embryonic polarity by controlling the localization and activity of PAR (partitioning-defective) proteins. Required for maintaining the asymmetric cortical localization of the anterior complex proteins par-3 and par-6, the posterior cortical protein par-2, and pkc-3. Involved in hypodermal cell fusion, together with pak-1 and ced-10, leading to embryonic body elongation, which involves dramatic cytoskeletal reorganization. During gonad morphogenesis, plays a role in dista [...] (191 aa)
B0563.7Uncharacterized calcium-binding protein B0563.7. (229 aa)
cal-2CALmodulin related genes. (171 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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