STRINGSTRING
wsp-1 wsp-1 exc-5 exc-5 mig-2 mig-2 vit-2 vit-2 unc-54 unc-54 exc-9 exc-9 rab-5 rab-5 unc-53 unc-53 unc-119 unc-119 glo-1 glo-1 cdc-42 cdc-42 vha-1 vha-1 gcc-2 gcc-2 eea-1 eea-1 chc-1 chc-1 act-5 act-5 rab-7 rab-7 rme-1 rme-1 tln-1 tln-1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
wsp-1WASP (Actin cytoskeleton modulator) homolog. (781 aa)
exc-5Uncharacterized protein. (861 aa)
mig-2Rac-like GTPase. (195 aa)
vit-2Vitellogenin-2; Precursor of the egg-yolk proteins that are sources of nutrients during embryonic development. (1613 aa)
unc-54Myosin-4; Required for muscle contraction. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1963 aa)
exc-9LIM zinc-binding domain-containing protein. (85 aa)
rab-5RAB family. (208 aa)
unc-53Adapter protein unc-53; Involved in the migration and outgrowth of muscles, axons and excretory canals. (1654 aa)
unc-119Protein unc-119; Myristoyl-binding protein that acts as a cargo adapter: specifically binds the myristoyl moiety of a subset of N-terminally myristoylated proteins and is required for their localization. Plays a key role in ciliary membrane localization of proteins. Required for the establishment or function of the nervous system. (244 aa)
glo-1Gut granule LOss. (212 aa)
cdc-42Cell division control protein 42 homolog; Plays an essential role in spindle orientation and organizing cellular and embryonic polarity by controlling the localization and activity of PAR (partitioning-defective) proteins. Required for maintaining the asymmetric cortical localization of the anterior complex proteins par-3 and par-6, the posterior cortical protein par-2, and pkc-3. Involved in hypodermal cell fusion, together with pak-1 and ced-10, leading to embryonic body elongation, which involves dramatic cytoskeletal reorganization. During gonad morphogenesis, plays a role in dista [...] (191 aa)
vha-1V-type proton ATPase 16 kDa proteolipid subunit 1; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. Required along with other vacuolar ATPase components for the removal of protein aggregates which form in immature oocytes in the distal gonad. This removal occurs as the oocytes mature and move to the proximal gonad, is triggered by the introduction of sperm through mating and occurs before fertilization. The introduction of sperm triggers V-AT [...] (169 aa)
gcc-2GRIP and coiled-coil domain-containing protein 2. (660 aa)
eea-1FYVE-type domain-containing protein. (1205 aa)
chc-1Probable clathrin heavy chain 1; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles (By similarity). May play a role in yolk protein clatherin-mediated endocytosis by oocytes during oogenesis ; Belongs to the clathrin heavy chain family. (1681 aa)
act-5ACTin. (375 aa)
rab-7RAB family. (209 aa)
rme-1Receptor Mediated Endocytosis; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (791 aa)
tln-1Talin. (2553 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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