node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
dyn-1 | hgrs-1 | C02C6.1b.1 | C07G1.5.2 | Dynamin; Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes, in particular endocytosis (By similarity). Required for coelomocyte endocytosis. Involved in apoptotic cell phagocytosis. Required for recruitment of phosphatidylinositol 3- kinase piki-1 to phagosomes. May play a role in rab-5 recruitment to cell-corpses-containing phagosomes but not to endosomes. Required for embryonic and larval development. Belongs to the TRAFAC class dynamin-like GTPase supe [...] | Hepatocyte Growth factor-Regulated TK Substrate (HRS) family. | 0.721 |
dyn-1 | tsg-101 | C02C6.1b.1 | C09G12.9.1 | Dynamin; Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes, in particular endocytosis (By similarity). Required for coelomocyte endocytosis. Involved in apoptotic cell phagocytosis. Required for recruitment of phosphatidylinositol 3- kinase piki-1 to phagosomes. May play a role in rab-5 recruitment to cell-corpses-containing phagosomes but not to endosomes. Required for embryonic and larval development. Belongs to the TRAFAC class dynamin-like GTPase supe [...] | Tumor Susceptibility Gene homolog. | 0.520 |
dyn-1 | vps-25 | C02C6.1b.1 | W02A11.2.2 | Dynamin; Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes, in particular endocytosis (By similarity). Required for coelomocyte endocytosis. Involved in apoptotic cell phagocytosis. Required for recruitment of phosphatidylinositol 3- kinase piki-1 to phagosomes. May play a role in rab-5 recruitment to cell-corpses-containing phagosomes but not to endosomes. Required for embryonic and larval development. Belongs to the TRAFAC class dynamin-like GTPase supe [...] | Related to yeast Vacuolar Protein Sorting factor. | 0.427 |
dyn-1 | vps-34 | C02C6.1b.1 | B0025.1a.1 | Dynamin; Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes, in particular endocytosis (By similarity). Required for coelomocyte endocytosis. Involved in apoptotic cell phagocytosis. Required for recruitment of phosphatidylinositol 3- kinase piki-1 to phagosomes. May play a role in rab-5 recruitment to cell-corpses-containing phagosomes but not to endosomes. Required for embryonic and larval development. Belongs to the TRAFAC class dynamin-like GTPase supe [...] | Phosphatidylinositol 3-kinase catalytic subunit type 3; Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate. Together with bec-1, mediates the production of phosphatidylinositol 3-phosphate on intracellular vesicles and thereby regulates membrane trafficking. Plays a role in endosome-to-Golgi retrograde transport of mig-14. Involved in clearance of apoptotic cell corpses by phagosomes. Phagosome maturation requires two sequential and non-overlapping pulses of phosphatidylinositol-3-phosphate (PI3P) on the vesicle surface which mediates recr [...] | 0.893 |
hgrs-1 | dyn-1 | C07G1.5.2 | C02C6.1b.1 | Hepatocyte Growth factor-Regulated TK Substrate (HRS) family. | Dynamin; Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes, in particular endocytosis (By similarity). Required for coelomocyte endocytosis. Involved in apoptotic cell phagocytosis. Required for recruitment of phosphatidylinositol 3- kinase piki-1 to phagosomes. May play a role in rab-5 recruitment to cell-corpses-containing phagosomes but not to endosomes. Required for embryonic and larval development. Belongs to the TRAFAC class dynamin-like GTPase supe [...] | 0.721 |
hgrs-1 | stam-1 | C07G1.5.2 | C34G6.7a.1 | Hepatocyte Growth factor-Regulated TK Substrate (HRS) family. | Signal transducing adapter molecule 1; Binds, sorts and targets the polycystin complex (lov-1 and pkd-2) for lysosomal degradation, acting on early endosomes located at the ciliary base. Functions in the germline together with the ephrin receptor (vab-1) signaling pathway to negatively regulate MAPK activation. May have a role as a positive regulator of meiotic maturation in oocytes, acting independently of vab-1. | 0.999 |
hgrs-1 | tsg-101 | C07G1.5.2 | C09G12.9.1 | Hepatocyte Growth factor-Regulated TK Substrate (HRS) family. | Tumor Susceptibility Gene homolog. | 0.998 |
hgrs-1 | vps-24 | C07G1.5.2 | T27F7.1.2 | Hepatocyte Growth factor-Regulated TK Substrate (HRS) family. | Related to yeast Vacuolar Protein Sorting factor. | 0.938 |
hgrs-1 | vps-25 | C07G1.5.2 | W02A11.2.2 | Hepatocyte Growth factor-Regulated TK Substrate (HRS) family. | Related to yeast Vacuolar Protein Sorting factor. | 0.940 |
hgrs-1 | vps-34 | C07G1.5.2 | B0025.1a.1 | Hepatocyte Growth factor-Regulated TK Substrate (HRS) family. | Phosphatidylinositol 3-kinase catalytic subunit type 3; Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate. Together with bec-1, mediates the production of phosphatidylinositol 3-phosphate on intracellular vesicles and thereby regulates membrane trafficking. Plays a role in endosome-to-Golgi retrograde transport of mig-14. Involved in clearance of apoptotic cell corpses by phagosomes. Phagosome maturation requires two sequential and non-overlapping pulses of phosphatidylinositol-3-phosphate (PI3P) on the vesicle surface which mediates recr [...] | 0.756 |
hgrs-1 | vps-36 | C07G1.5.2 | F17C11.8.2 | Hepatocyte Growth factor-Regulated TK Substrate (HRS) family. | GLUE N-terminal domain-containing protein. | 0.954 |
stam-1 | hgrs-1 | C34G6.7a.1 | C07G1.5.2 | Signal transducing adapter molecule 1; Binds, sorts and targets the polycystin complex (lov-1 and pkd-2) for lysosomal degradation, acting on early endosomes located at the ciliary base. Functions in the germline together with the ephrin receptor (vab-1) signaling pathway to negatively regulate MAPK activation. May have a role as a positive regulator of meiotic maturation in oocytes, acting independently of vab-1. | Hepatocyte Growth factor-Regulated TK Substrate (HRS) family. | 0.999 |
stam-1 | tsg-101 | C34G6.7a.1 | C09G12.9.1 | Signal transducing adapter molecule 1; Binds, sorts and targets the polycystin complex (lov-1 and pkd-2) for lysosomal degradation, acting on early endosomes located at the ciliary base. Functions in the germline together with the ephrin receptor (vab-1) signaling pathway to negatively regulate MAPK activation. May have a role as a positive regulator of meiotic maturation in oocytes, acting independently of vab-1. | Tumor Susceptibility Gene homolog. | 0.991 |
stam-1 | vps-24 | C34G6.7a.1 | T27F7.1.2 | Signal transducing adapter molecule 1; Binds, sorts and targets the polycystin complex (lov-1 and pkd-2) for lysosomal degradation, acting on early endosomes located at the ciliary base. Functions in the germline together with the ephrin receptor (vab-1) signaling pathway to negatively regulate MAPK activation. May have a role as a positive regulator of meiotic maturation in oocytes, acting independently of vab-1. | Related to yeast Vacuolar Protein Sorting factor. | 0.927 |
stam-1 | vps-25 | C34G6.7a.1 | W02A11.2.2 | Signal transducing adapter molecule 1; Binds, sorts and targets the polycystin complex (lov-1 and pkd-2) for lysosomal degradation, acting on early endosomes located at the ciliary base. Functions in the germline together with the ephrin receptor (vab-1) signaling pathway to negatively regulate MAPK activation. May have a role as a positive regulator of meiotic maturation in oocytes, acting independently of vab-1. | Related to yeast Vacuolar Protein Sorting factor. | 0.914 |
stam-1 | vps-36 | C34G6.7a.1 | F17C11.8.2 | Signal transducing adapter molecule 1; Binds, sorts and targets the polycystin complex (lov-1 and pkd-2) for lysosomal degradation, acting on early endosomes located at the ciliary base. Functions in the germline together with the ephrin receptor (vab-1) signaling pathway to negatively regulate MAPK activation. May have a role as a positive regulator of meiotic maturation in oocytes, acting independently of vab-1. | GLUE N-terminal domain-containing protein. | 0.933 |
tsg-101 | dyn-1 | C09G12.9.1 | C02C6.1b.1 | Tumor Susceptibility Gene homolog. | Dynamin; Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes, in particular endocytosis (By similarity). Required for coelomocyte endocytosis. Involved in apoptotic cell phagocytosis. Required for recruitment of phosphatidylinositol 3- kinase piki-1 to phagosomes. May play a role in rab-5 recruitment to cell-corpses-containing phagosomes but not to endosomes. Required for embryonic and larval development. Belongs to the TRAFAC class dynamin-like GTPase supe [...] | 0.520 |
tsg-101 | hgrs-1 | C09G12.9.1 | C07G1.5.2 | Tumor Susceptibility Gene homolog. | Hepatocyte Growth factor-Regulated TK Substrate (HRS) family. | 0.998 |
tsg-101 | stam-1 | C09G12.9.1 | C34G6.7a.1 | Tumor Susceptibility Gene homolog. | Signal transducing adapter molecule 1; Binds, sorts and targets the polycystin complex (lov-1 and pkd-2) for lysosomal degradation, acting on early endosomes located at the ciliary base. Functions in the germline together with the ephrin receptor (vab-1) signaling pathway to negatively regulate MAPK activation. May have a role as a positive regulator of meiotic maturation in oocytes, acting independently of vab-1. | 0.991 |
tsg-101 | vps-24 | C09G12.9.1 | T27F7.1.2 | Tumor Susceptibility Gene homolog. | Related to yeast Vacuolar Protein Sorting factor. | 0.980 |