STRINGSTRING
Y54E10BR.5 Y54E10BR.5 clp-4 clp-4 clp-10 clp-10 dhc-4 dhc-4 clp-9 clp-9 clp-2 clp-2 cpl-1 cpl-1 plk-3 plk-3 clp-8 clp-8 sas-4 sas-4 plk-1 plk-1 icl-1 icl-1 dhc-3 dhc-3 clp-6 clp-6 plk-2 plk-2 unc-51 unc-51 clp-3 clp-3 clp-7 clp-7
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Y54E10BR.5Signal peptidase complex catalytic subunit SEC11. (183 aa)
clp-4Calpain catalytic domain-containing protein; Belongs to the peptidase C2 family. (716 aa)
clp-10Calpain catalytic domain-containing protein; Belongs to the peptidase C2 family. (634 aa)
dhc-4DHC_N2 domain-containing protein. (2727 aa)
clp-9Calpain catalytic domain-containing protein; Belongs to the peptidase C2 family. (718 aa)
clp-2Calpain catalytic domain-containing protein; Belongs to the peptidase C2 family. (805 aa)
cpl-1Cathepsin L-like; Cysteine protease which plays an essential role in the degradation of proteins in lysosomes. During early embryogenesis, maternally required for the proteolytic processing of yolk proteins in platelets, a lysosome- like structure where a slow and controlled degradation of yolk proteins occurs. In the gonad, required for the clearance of apoptotic germ cells in the engulfing cell phagolysosomes. In embryos, required for the degradation of endocytic and autophagic cargos. In embryos, may play a role in the degradation of lipid-containing droplets. Required for larval de [...] (337 aa)
plk-3Serine/threonine-protein kinase plk-3; May be required for cell division and may have a role during G1 or S phase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily. (615 aa)
clp-8Calpain catalytic domain-containing protein; Belongs to the peptidase C2 family. (646 aa)
sas-4Spindle assembly abnormal protein 4; Required for centrosome duplication. Plays a central role in determining centrosome size. (808 aa)
plk-1Serine/threonine-protein kinase plk-1; Required for oocyte nuclear envelope breakdown before entry of oocyte into spermatheca. In meiotic cells, required for spindle dynamics and probably for spindle attachment to the chromosomes. Zygotic role in the development of the germline and nerve cord. In mitotic cells, plays a role in spindle organization and centrosome maturation. Involved in asymmetric nuclear localization of cdc- 25.1 during embryogenesis which affects cell division timing. Together with plk- 2, regulates cytoplasm polarity in early embryos. May play a minor role in chromos [...] (649 aa)
icl-1Bifunctional glyoxylate cycle protein; In the C-terminal section; belongs to the malate synthase family. (968 aa)
dhc-3Dynein Heavy Chain. (3275 aa)
clp-6Calpain catalytic domain-containing protein; Belongs to the peptidase C2 family. (627 aa)
plk-2Serine/threonine-protein kinase plk-2; Serine/threonine-protein kinase which plays a role, during oogenesis, in chromosome pairing and synapsis, by facilitating the recruitment and attachment of meiotic chromosomes to the nuclear envelope during prophase. Regulates the formation of sun-1 patches along the nuclear envelope. Promotes meiotic nuclei apoptosis in response to chromosomal asynapsis. Plays a redundant role with plk-1 in the establishment of cell polarity downstream of mex-5 and mex-6 during the first embryonic cell divisions. Plays a role in nicotinic acetylcholine receptor- [...] (632 aa)
unc-51Serine/threonine-protein kinase unc-51; Protein kinase important for axonal elongation and axonal guidance. Functions in the CAN axons to direct both anterior and posterior migrations. Phosphorylates both unc-14 and vab-8. Component of the unc-51/atg-13 complex that is probably recruited by lgg-1 to preautophagosomes and is required for autophagosome formation. Interaction with autophagy related proteins such as atg-13 links it to the autophagy machinery to in turn promote P-granule degradation in somatic cells. Plays a role in mitophagy during limited food availability. Regulates cell [...] (856 aa)
clp-3Calpain catalytic domain-containing protein; Belongs to the peptidase C2 family. (752 aa)
clp-7Calpain catalytic domain-containing protein; Belongs to the peptidase C2 family. (778 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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