Polyprenol reductase; Plays a key role in early steps of protein N-linked glycosylation by being required for the conversion of polyprenol into dolichol. Dolichols are required for the synthesis of dolichol-linked monosaccharides and the oligosaccharide precursor used for N- glycosylation. Acts as a polyprenol reductase that promotes the reduction of the alpha-isoprene unit of polyprenols into dolichols in a NADP-dependent mechanism (By similarity).

Diphosphomevalonate decarboxylase; Performs the first committed step in the biosynthesis of isoprenes.

Polyprenol reductase; Plays a key role in early steps of protein N-linked glycosylation by being required for the conversion of polyprenol into dolichol. Dolichols are required for the synthesis of dolichol-linked monosaccharides and the oligosaccharide precursor used for N- glycosylation. Acts as a polyprenol reductase that promotes the reduction of the alpha-isoprene unit of polyprenols into dolichols in a NADP-dependent mechanism (By similarity).

Farnesyl DiPhosphate Synthetase; Belongs to the FPP/GGPP synthase family.

Polyprenol reductase; Plays a key role in early steps of protein N-linked glycosylation by being required for the conversion of polyprenol into dolichol. Dolichols are required for the synthesis of dolichol-linked monosaccharides and the oligosaccharide precursor used for N- glycosylation. Acts as a polyprenol reductase that promotes the reduction of the alpha-isoprene unit of polyprenols into dolichols in a NADP-dependent mechanism (By similarity).

Glutamate-gated chloride channel subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family.

Polyprenol reductase; Plays a key role in early steps of protein N-linked glycosylation by being required for the conversion of polyprenol into dolichol. Dolichols are required for the synthesis of dolichol-linked monosaccharides and the oligosaccharide precursor used for N- glycosylation. Acts as a polyprenol reductase that promotes the reduction of the alpha-isoprene unit of polyprenols into dolichols in a NADP-dependent mechanism (By similarity).

Nudix hydrolase domain-containing protein.

Polyprenol reductase; Plays a key role in early steps of protein N-linked glycosylation by being required for the conversion of polyprenol into dolichol. Dolichols are required for the synthesis of dolichol-linked monosaccharides and the oligosaccharide precursor used for N- glycosylation. Acts as a polyprenol reductase that promotes the reduction of the alpha-isoprene unit of polyprenols into dolichols in a NADP-dependent mechanism (By similarity).

Fibronectin type-III domain-containing protein.

Diphosphomevalonate decarboxylase; Performs the first committed step in the biosynthesis of isoprenes.

Polyprenol reductase; Plays a key role in early steps of protein N-linked glycosylation by being required for the conversion of polyprenol into dolichol. Dolichols are required for the synthesis of dolichol-linked monosaccharides and the oligosaccharide precursor used for N- glycosylation. Acts as a polyprenol reductase that promotes the reduction of the alpha-isoprene unit of polyprenols into dolichols in a NADP-dependent mechanism (By similarity).

Diphosphomevalonate decarboxylase; Performs the first committed step in the biosynthesis of isoprenes.

Atypical kinase coq-8, mitochondrial; Atypical kinase involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration. Its substrate specificity is unclear: either acts as protein kinase that phosphorylates other proteins in the CoQ complex to stabilize their interactions or acts as a small molecule kinase that phosphorylates a prenyl lipid in the ubiquinone biosynthesis pathway.

Diphosphomevalonate decarboxylase; Performs the first committed step in the biosynthesis of isoprenes.

Farnesyl DiPhosphate Synthetase; Belongs to the FPP/GGPP synthase family.

Diphosphomevalonate decarboxylase; Performs the first committed step in the biosynthesis of isoprenes.

3-hydroxy-3-methylglutaryl coenzyme A reductase.

Diphosphomevalonate decarboxylase; Performs the first committed step in the biosynthesis of isoprenes.

Hydroxymethylglutaryl-CoA synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.

Diphosphomevalonate decarboxylase; Performs the first committed step in the biosynthesis of isoprenes.

Nudix hydrolase domain-containing protein.

Diphosphomevalonate decarboxylase; Performs the first committed step in the biosynthesis of isoprenes.

Ras-related protein rac-2; During gonad morphogenesis, plays a role in distal tip cell (DTC)-mediated guidance of gonad elongation.

Caveolin-1; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity.

Cell division control protein 42 homolog; Plays an essential role in spindle orientation and organizing cellular and embryonic polarity by controlling the localization and activity of PAR (partitioning-defective) proteins. Required for maintaining the asymmetric cortical localization of the anterior complex proteins par-3 and par-6, the posterior cortical protein par-2, and pkc-3. Involved in hypodermal cell fusion, together with pak-1 and ced-10, leading to embryonic body elongation, which involves dramatic cytoskeletal reorganization. During gonad morphogenesis, plays a role in dista [...]

Caveolin-1; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity.

Ras-related protein ced-10; Required in engulfing to control the phagocytosis of apoptotic cell corpses. Required in embryonic development for the correct positioning and orientation of the mitotic spindles and division planes in blastomere cells. Involved in hypodermal cell fusion, together with pak-1 and cdc-42, leading to embryonic body elongation, which involves dramatic cytoskeletal reorganization. ced-2 and ced-5 function to activate ced-10 in a GTPase signaling pathway that controls the polarized extension of cell surfaces. Plays a redundant role with mig-2 in dorsal axonal guid [...]

Caveolin-1; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity.

Receptor tyrosine-protein kinase let-23; Tyrosine-protein kinase receptor which, upon binding ligand lin-3, activates 2 signaling cascades: the let-60/Ras and MAP kinase signaling pathway and the let-60-independent phospholipase C-mediated Ca(2+) signaling pathway. Each pathway regulates distinct functions. By activating let-60/Ras, regulates larval development, induction of vulva cell precursors during vulva development, male spicule formation and posterior development of the epidermis. Probably by activating phospholipase plc-3 and inositol 1,4,5-trisphosphate receptor itr-1 signalin [...]

Caveolin-1; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity.

NPC intracellular cholesterol transporter 1 homolog 1; Involved in the uptake or utilization of cholesterol (By similarity). Ncr-1 and ncr-2 act redundantly to prevent dauer larva formation under favorable growth conditions, and are required for the normal functioning of ADF, ASI and ASG neurons. Belongs to the patched family.

Caveolin-1; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity.

Ras-related protein rac-2; During gonad morphogenesis, plays a role in distal tip cell (DTC)-mediated guidance of gonad elongation.

Caveolin-1; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity.

Ras-like GTP-binding protein rhoA; Required for ventral migration of epidermal cells during ventral enclosure in the embryo and for cell elongation. Also required for ventral migration of P cells during larval development. Involved in asymmetric spindle positioning during anaphase and establishment of cell polarity during embryo development. In adults, involved in regulation of multiple processes including locomotion, pharyngeal pumping, fecundity, ovulation, defecation and body morphology. In body wall muscles, regulates organization of myosin thick filaments downstream of unc-89. Ass [...]

Caveolin-1; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity.

Receptor Mediated Endocytosis.

Cell division control protein 42 homolog; Plays an essential role in spindle orientation and organizing cellular and embryonic polarity by controlling the localization and activity of PAR (partitioning-defective) proteins. Required for maintaining the asymmetric cortical localization of the anterior complex proteins par-3 and par-6, the posterior cortical protein par-2, and pkc-3. Involved in hypodermal cell fusion, together with pak-1 and ced-10, leading to embryonic body elongation, which involves dramatic cytoskeletal reorganization. During gonad morphogenesis, plays a role in dista [...]

Caveolin-1; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity.