STRINGSTRING
ctl-1 ctl-1 gst-1 gst-1 avr-15 avr-15 ges-1 ges-1 gldc-1 gldc-1 daf-16 daf-16 ugt-56 ugt-56 acdh-10 acdh-10 acdh-4 acdh-4 ugt-12 ugt-12 acdh-7 acdh-7 hsp-16.11 hsp-16.11 hsp-16.48 hsp-16.48 hsp-16.1 hsp-16.1 hsp-16.49 hsp-16.49 fat-6 fat-6 fat-5 fat-5 hsf-1 hsf-1 ctl-2 ctl-2 glc-3 glc-3 avr-14 avr-14 cyp-34A9 cyp-34A9 ugt-46 ugt-46 icl-1 icl-1 cyp-35C1 cyp-35C1 hsp-70 hsp-70 acdh-2 acdh-2 C23G10.11 C23G10.11 dod-3 dod-3 glc-4 glc-4 acdh-13 acdh-13 acdh-5 acdh-5 ilys-3 ilys-3 acs-17 acs-17 gale-1 gale-1 acdh-1 acdh-1 gbh-1 gbh-1 acdh-12 acdh-12 fat-7 fat-7 glc-1 glc-1 unc-54 unc-54 elo-2 elo-2 acdh-9 acdh-9 acs-2 acs-2 cyp-37B1 cyp-37B1 gst-38 gst-38 ama-1 ama-1 elo-5 elo-5 elo-6 elo-6 sip-1 sip-1 scl-2 scl-2 dhrs-4 dhrs-4 lys-5 lys-5 lys-6 lys-6 acox-3 acox-3 vit-3 vit-3 vit-4 vit-4 cyn-4 cyn-4 acdh-8 acdh-8 acdh-3 acdh-3 pgp-1 pgp-1 gst-4 gst-4 vit-1 vit-1 cpt-4 cpt-4 asah-1 asah-1 mtl-1 mtl-1 sodh-1 sodh-1 gbh-2 gbh-2 ger-1 ger-1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ctl-1Catalase-2; Catalase involved in the oxidative stress response serving to protect cells from toxicity (Probable). For instance plays a role in defending against oxidative damage induced by excessive copper stress. Not required for maintaining normal lifespan. (497 aa)
gst-1Glutathione S-transferase P; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles (By similarity). Prevents dopaminergic CEP neuron degeneration in response to Mn(2+). (208 aa)
avr-15Neur_chan_memb domain-containing protein; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (657 aa)
ges-1Gut esterase 1; Belongs to the type-B carboxylesterase/lipase family. (562 aa)
gldc-1Glycine cleavage system P protein; The glycine cleavage system catalyzes the degradation of glycine. (979 aa)
daf-16Forkhead box protein O; Forkhead-type transcription factor. Binds to the promoters of genes that contain the daf-16 binding element (DBE), TTGTTTAC, in their regulatory region. Functions in the Insulin/IGF-1-like signaling (IIS) mediated pathway which affects lipogenesis, lifespan, starvation survival, heat shock and oxidative stress responses, and dauer formation. Longevity signaling predominantly arises from expression in the intestine. Daf-16 transcriptional activity is negatively regulated by cytoplasmic sequestration by association with ftt-2. Inhibition is required for the carbon [...] (541 aa)
ugt-56Putative UDP-glucuronosyltransferase ugt-56; Belongs to the UDP-glycosyltransferase family. (524 aa)
acdh-10Probable medium-chain specific acyl-CoA dehydrogenase 10, mitochondrial; This enzyme is specific for acyl chain lengths of 4 to 16. Belongs to the acyl-CoA dehydrogenase family. (417 aa)
acdh-4Acyl CoA DeHydrogenase. (385 aa)
ugt-12UDP-GlucuronosylTransferase. (534 aa)
acdh-7Acyl CoA DeHydrogenase. (412 aa)
hsp-16.11Heat shock protein Hsp-16.1/Hsp-16.11. (145 aa)
hsp-16.48Heat shock protein Hsp-16.48/Hsp-16.49; Belongs to the small heat shock protein (HSP20) family. (143 aa)
hsp-16.1Heat shock protein Hsp-16.1/Hsp-16.11. (145 aa)
hsp-16.49Heat shock protein Hsp-16.48/Hsp-16.49. (143 aa)
fat-6Delta(9)-fatty-acid desaturase fat-6; Delta(9)-fatty-acid desaturase that acts preferentially on stearoyl-CoA. Also acts on vaccenyl-coA and heptadecanyol-CoA. Belongs to the fatty acid desaturase type 1 family. (339 aa)
fat-5Delta(9)-fatty-acid desaturase fat-5; Delta(9)-fatty-acid desaturase that acts preferentially on palmitoyl-CoA. Also acts on pentadecanoyl-coA and myristoyl-CoA. (333 aa)
hsf-1HSF_DOMAIN domain-containing protein. (671 aa)
ctl-2Peroxisomal catalase 1; Peroxisomal catalase involved in the oxidative stress response serving to protect cells from toxicity. Plays a role in maintaining normal lifespan. Plays a role in regulating the response to pathogens such as E.faecalis. (500 aa)
glc-3Glutamate-gated chloride channel subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (484 aa)
avr-14Uncharacterized protein; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (430 aa)
cyp-34A9CYtochrome P450 family; Belongs to the cytochrome P450 family. (516 aa)
ugt-46Putative UDP-glucuronosyltransferase ugt-46; Belongs to the UDP-glycosyltransferase family. (531 aa)
icl-1Bifunctional glyoxylate cycle protein; In the C-terminal section; belongs to the malate synthase family. (968 aa)
cyp-35C1CYtochrome P450 family; Belongs to the cytochrome P450 family. (495 aa)
hsp-70Heat Shock Protein; Belongs to the heat shock protein 70 family. (643 aa)
acdh-2Acyl CoA DeHydrogenase. (386 aa)
C23G10.11Uncharacterized protein. (63 aa)
dod-3Downstream Of DAF-16 (Regulated by DAF-16). (106 aa)
glc-4Glutamate-gated ChLoride channel; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (500 aa)
acdh-13Acyl CoA DeHydrogenase. (617 aa)
acdh-5Acyl CoA DeHydrogenase. (442 aa)
ilys-3Invertebrate-type lysozyme 3; Has bacteriolytic activity against Gram-positive bacteria. Plays a role in defense against bacterial pathogens. Involved in pharyngeal grinder function by enabling proper lysis of ingested bacteria; Belongs to the glycosyl hydrolase 22 family. Type-I lysozyme subfamily. (139 aa)
acs-17Fatty Acid CoA Synthetase family. (718 aa)
gale-1UDP-glucose 4-epimerase; Catalyzes two distinct but analogous reactions: the reversible epimerization of UDP-glucose to UDP-galactose and the reversible epimerization of UDP-N-acetylglucosamine to UDP-N- acetylgalactosamine. The reaction with UDP-Gal plays a critical role in the Leloir pathway of galactose catabolism in which galactose is converted to the glycolytic intermediate glucose 6-phosphate. It contributes to the catabolism of dietary galactose and enables the endogenous biosynthesis of both UDP-Gal and UDP-GalNAc when exogenous sources are limited. Both UDP-sugar interconversi [...] (349 aa)
acdh-1Acyl CoA DeHydrogenase. (427 aa)
gbh-1Probable gamma-butyrobetaine dioxygenase; Catalyzes the formation of L-carnitine from gamma- butyrobetaine. (421 aa)
acdh-12Acyl CoA DeHydrogenase. (613 aa)
fat-7Delta(9)-fatty-acid desaturase fat-7; Delta(9)-fatty-acid desaturase that acts preferentially on stearoyl-CoA. Also acts on vaccenyl-coA, heptadecanyol-CoA, and palmitoyl-CoA. (338 aa)
glc-1Glutamate-gated chloride channel alpha; Glutamate-gated chloride channel subunit; channel properties depend on the subunit composition. Glutamate binding triggers a rapidly reversible current in heteromeric channels formed by glc-1 and glc-2, while the anti-helmintic drug ivermectin and other avermectins trigger a permanently open channel configuration. Channels containing only glc- 1 are activated by ivermectin, but not by glutamate alone (in vitro). The heteromeric channel formed by glc-1 and glc-2 is also activated by ibotenate, and it is blocked by picrotoxin and flufenamic acid. P [...] (461 aa)
unc-54Myosin-4; Required for muscle contraction. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1963 aa)
elo-2Elongation of very long chain fatty acids protein. (274 aa)
acdh-9Acyl CoA DeHydrogenase. (409 aa)
acs-2Fatty Acid CoA Synthetase family. (618 aa)
cyp-37B1CYtochrome P450 family; Belongs to the cytochrome P450 family. (509 aa)
gst-38Glutathione S-Transferase. (209 aa)
ama-1DNA-directed RNA polymerase II subunit RPB1; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Forms the polymerase active center together with the second largest subunit. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB1 is part of the core element with the central large cl [...] (1856 aa)
elo-5Elongation of very long chain fatty acids protein 5; Condensing enzyme that elongates saturated and monounsaturated very long chain fatty acids (VLCFAs) and monomethyl branched-chain fatty acids (mmBCFAs). Required for the formation of isopentadecanoate (C15iso) and isoheptadecanoate (C17iso). Belongs to the ELO family. (274 aa)
elo-6Elongation of very long chain fatty acids protein 6; Condensing enzyme that elongates saturated and monounsaturated very long chain fatty acids (VLCFAs) and monomethyl branched-chain fatty acids (mmBCFAs). Required for the formation of isoheptadecanoate (C17iso). (274 aa)
sip-1Stress-induced protein 1; Belongs to the small heat shock protein (HSP20) family. (159 aa)
scl-2SCP domain-containing protein; Belongs to the CRISP family. (207 aa)
dhrs-4Dehydrogenase/reductase SDR family member 4; Catalyzes the reduction of isatin, 4-oxonon-2-enal, 9,10- phenanthrenequinone, menadione, 2,3-hexaenadione, 3,4-hexanedione and 2,3-heptanedione. (260 aa)
lys-5Lysozyme-like protein 5; Plays a role in resistance to Gram-positive bacteria S.aureus or B.thuringiensis infection. (215 aa)
lys-6LYSozyme. (214 aa)
acox-3Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. (667 aa)
vit-3Vitellogenin-3; Precursor of the egg-yolk proteins that are sources of nutrients during embryonic development. (1603 aa)
vit-4Vitellogenin-4; Precursor of the egg-yolk proteins that are sources of nutrients during embryonic development. (1603 aa)
cyn-4Peptidyl-prolyl cis-trans isomerase 4; May catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides thereby assisting the folding of proteins. May also function as a chaperone, playing a role in intracellular transport of proteins. May also have a protein ubiquitin ligase activity acting as an E3 ubiquitin protein ligase or as a ubiquitin-ubiquitin ligase promoting elongation of ubiquitin chains on proteins. Influences the hermaphrodite switch from spermatogenesis to oogenesis. Required for body wall muscle cell development. (523 aa)
acdh-8Acyl CoA DeHydrogenase. (412 aa)
acdh-3Acyl CoA DeHydrogenase. (419 aa)
pgp-1Multidrug resistance protein pgp-1; Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells; Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily. (1321 aa)
gst-4Glutathione S-transferase 4; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles (By similarity). May play a role in the detoxification of reactive oxygen species produced during pathogenic bacterial infection. (207 aa)
vit-1Vitellogenin-1; Precursor of the egg-yolk proteins that are sources of nutrients during embryonic development. (1616 aa)
cpt-4Carn_acyltransf domain-containing protein. (748 aa)
asah-1Acid ceramidase subunit alpha; Lysosomal ceramidase that hydrolyzes sphingolipid ceramides into sphingosine and free fatty acids at acidic pH. (393 aa)
mtl-1Metallothionein-1; This protein binds cations of several transition elements. (75 aa)
sodh-1Alcohol dehydrogenase 1; Belongs to the zinc-containing alcohol dehydrogenase family. (349 aa)
gbh-2Gamma Butyrobetaine Hydroxylase. (409 aa)
ger-1GDP-L-fucose synthase; Catalyzes the two-step NADP-dependent conversion of GDP-4- dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction; Belongs to the NAD(P)-dependent epimerase/dehydratase family. Fucose synthase subfamily. (315 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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