STRINGSTRING
vps-34 vps-34 vps-15 vps-15 vps-28 vps-28 snx-6 snx-6 rabs-5 rabs-5 itsn-1 itsn-1 arf-6 arf-6 dnj-25 dnj-25 act-5 act-5 chc-1 chc-1 eea-1 eea-1 epn-1 epn-1 amph-1 amph-1 fcho-1 fcho-1 rab-5 rab-5 snx-27 snx-27 snx-17 snx-17 vps-36 vps-36 rab-8 rab-8 vps-37 vps-37 stam-1 stam-1 mvb-12 mvb-12 dyn-1 dyn-1 arf-1.2 arf-1.2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
vps-34Phosphatidylinositol 3-kinase catalytic subunit type 3; Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate. Together with bec-1, mediates the production of phosphatidylinositol 3-phosphate on intracellular vesicles and thereby regulates membrane trafficking. Plays a role in endosome-to-Golgi retrograde transport of mig-14. Involved in clearance of apoptotic cell corpses by phagosomes. Phagosome maturation requires two sequential and non-overlapping pulses of phosphatidylinositol-3-phosphate (PI3P) on the vesicle surface which mediates recr [...] (901 aa)
vps-15Related to yeast Vacuolar Protein Sorting factor. (1354 aa)
vps-28Vacuolar protein sorting-associated protein 28 homolog; Component of the ESCRT-I complex, a regulator of vesicular trafficking process; Belongs to the VPS28 family. (210 aa)
snx-6PX domain-containing protein. (478 aa)
rabs-5FYVE-type domain-containing protein. (565 aa)
itsn-1ITSN (Intersectin) family. (1087 aa)
arf-6ADP-Ribosylation Factor related; Belongs to the small GTPase superfamily. Arf family. (175 aa)
dnj-25J domain-containing protein. (784 aa)
act-5ACTin. (375 aa)
chc-1Probable clathrin heavy chain 1; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles (By similarity). May play a role in yolk protein clatherin-mediated endocytosis by oocytes during oogenesis ; Belongs to the clathrin heavy chain family. (1681 aa)
eea-1FYVE-type domain-containing protein. (1205 aa)
epn-1ENTH domain-containing protein. (469 aa)
amph-1AMPHiphysin homolog. (461 aa)
fcho-1FCH domain Only (FCH stands for Fes/CIP4 homology domain). (968 aa)
rab-5RAB family. (208 aa)
snx-27Sorting NeXin. (578 aa)
snx-17Sorting nexin-17 homolog; Critical regulator of endosomal recycling of numerous receptors, channels, and other transmembrane proteins. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)). (540 aa)
vps-36GLUE N-terminal domain-containing protein. (383 aa)
rab-8RAB family. (211 aa)
vps-37VPS37 C-terminal domain-containing protein. (234 aa)
stam-1Signal transducing adapter molecule 1; Binds, sorts and targets the polycystin complex (lov-1 and pkd-2) for lysosomal degradation, acting on early endosomes located at the ciliary base. Functions in the germline together with the ephrin receptor (vab-1) signaling pathway to negatively regulate MAPK activation. May have a role as a positive regulator of meiotic maturation in oocytes, acting independently of vab-1. (457 aa)
mvb-12MVB (Yeast MultiVesicular Body sorting factor) related. (277 aa)
dyn-1Dynamin; Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes, in particular endocytosis (By similarity). Required for coelomocyte endocytosis. Involved in apoptotic cell phagocytosis. Required for recruitment of phosphatidylinositol 3- kinase piki-1 to phagosomes. May play a role in rab-5 recruitment to cell-corpses-containing phagosomes but not to endosomes. Required for embryonic and larval development. Belongs to the TRAFAC class dynamin-like GTPase supe [...] (838 aa)
arf-1.2ADP-ribosylation factor 1-like 2; GTP-binding protein involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus. Involved in endoplasmic reticulum dynamics during embryogenesis. Also required for adult germline function. Plays a role in cell shedding during embryogenesis probably by promoting the endocytosis of cell adhesion molecules. During neurogenesis, involved in cell autonomous Q.p neuroblast asymmetric divisions that generate one precursor cell and one apoptotic cell, probably by controlling endocytosis. (181 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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