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vps-34 | Phosphatidylinositol 3-kinase catalytic subunit type 3; Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate. Together with bec-1, mediates the production of phosphatidylinositol 3-phosphate on intracellular vesicles and thereby regulates membrane trafficking. Plays a role in endosome-to-Golgi retrograde transport of mig-14. Involved in clearance of apoptotic cell corpses by phagosomes. Phagosome maturation requires two sequential and non-overlapping pulses of phosphatidylinositol-3-phosphate (PI3P) on the vesicle surface which mediates recr [...] (901 aa) | ||||
vps-15 | Related to yeast Vacuolar Protein Sorting factor. (1354 aa) | ||||
vps-28 | Vacuolar protein sorting-associated protein 28 homolog; Component of the ESCRT-I complex, a regulator of vesicular trafficking process; Belongs to the VPS28 family. (210 aa) | ||||
snx-6 | PX domain-containing protein. (478 aa) | ||||
rabs-5 | FYVE-type domain-containing protein. (565 aa) | ||||
itsn-1 | ITSN (Intersectin) family. (1087 aa) | ||||
arf-6 | ADP-Ribosylation Factor related; Belongs to the small GTPase superfamily. Arf family. (175 aa) | ||||
dnj-25 | J domain-containing protein. (784 aa) | ||||
act-5 | ACTin. (375 aa) | ||||
chc-1 | Probable clathrin heavy chain 1; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles (By similarity). May play a role in yolk protein clatherin-mediated endocytosis by oocytes during oogenesis ; Belongs to the clathrin heavy chain family. (1681 aa) | ||||
eea-1 | FYVE-type domain-containing protein. (1205 aa) | ||||
epn-1 | ENTH domain-containing protein. (469 aa) | ||||
amph-1 | AMPHiphysin homolog. (461 aa) | ||||
fcho-1 | FCH domain Only (FCH stands for Fes/CIP4 homology domain). (968 aa) | ||||
rab-5 | RAB family. (208 aa) | ||||
snx-27 | Sorting NeXin. (578 aa) | ||||
snx-17 | Sorting nexin-17 homolog; Critical regulator of endosomal recycling of numerous receptors, channels, and other transmembrane proteins. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)). (540 aa) | ||||
vps-36 | GLUE N-terminal domain-containing protein. (383 aa) | ||||
rab-8 | RAB family. (211 aa) | ||||
vps-37 | VPS37 C-terminal domain-containing protein. (234 aa) | ||||
stam-1 | Signal transducing adapter molecule 1; Binds, sorts and targets the polycystin complex (lov-1 and pkd-2) for lysosomal degradation, acting on early endosomes located at the ciliary base. Functions in the germline together with the ephrin receptor (vab-1) signaling pathway to negatively regulate MAPK activation. May have a role as a positive regulator of meiotic maturation in oocytes, acting independently of vab-1. (457 aa) | ||||
mvb-12 | MVB (Yeast MultiVesicular Body sorting factor) related. (277 aa) | ||||
dyn-1 | Dynamin; Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes, in particular endocytosis (By similarity). Required for coelomocyte endocytosis. Involved in apoptotic cell phagocytosis. Required for recruitment of phosphatidylinositol 3- kinase piki-1 to phagosomes. May play a role in rab-5 recruitment to cell-corpses-containing phagosomes but not to endosomes. Required for embryonic and larval development. Belongs to the TRAFAC class dynamin-like GTPase supe [...] (838 aa) | ||||
arf-1.2 | ADP-ribosylation factor 1-like 2; GTP-binding protein involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus. Involved in endoplasmic reticulum dynamics during embryogenesis. Also required for adult germline function. Plays a role in cell shedding during embryogenesis probably by promoting the endocytosis of cell adhesion molecules. During neurogenesis, involved in cell autonomous Q.p neuroblast asymmetric divisions that generate one precursor cell and one apoptotic cell, probably by controlling endocytosis. (181 aa) |