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dat-1 dat-1 B0563.7 B0563.7 acy-2 acy-2 cal-1 cal-1 unc-47 unc-47 dop-3 dop-3 cal-4 cal-4 eri-1 eri-1 rsbp-1 rsbp-1 unc-119 unc-119 cal-3 cal-3 egl-30 egl-30 myo-3 myo-3 unc-43 unc-43 K03A1.4 K03A1.4 rgs-7 rgs-7 cal-7 cal-7 egl-10 egl-10 flp-1 flp-1 grk-1 grk-1 acy-1 acy-1 acy-3 acy-3 rgs-6 rgs-6 goa-1 goa-1 cal-2 cal-2 eat-16 eat-16 cmd-1 cmd-1 kin-1 kin-1 lin-15B lin-15B unc-17 unc-17
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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dat-1Sodium-dependent dopamine transporter; Dopamine transporter. Terminates the action of dopamine by its high affinity sodium-dependent reuptake into presynaptic terminals. (615 aa)
B0563.7Uncharacterized calcium-binding protein B0563.7. (229 aa)
acy-2Adenylyl CYclase; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1080 aa)
cal-1Calmodulin-like protein; This protein resembles calmodulin in sequence but possibly resembles troponin C in function. (180 aa)
unc-47Vesicular GABA transporter; Involved in the uptake of GABA into the synaptic vesicles. Belongs to the amino acid/polyamine transporter 2 family. (486 aa)
dop-3Dopamine receptor 3; Receptor for dopamine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. In terms of antagonist responses, would be classed with the D2-like dopamine receptor group. Mediates the effect of dopamine on the inhibition of locomotion. Acts as an antagonist of dop-1. (607 aa)
cal-4CALmodulin related genes. (236 aa)
eri-13'-5' exonuclease eri-1; RNA exonuclease that acts as a negative regulator of RNA interference (RNAi). Probably acts by degrading the 3'-overhangs of short interfering RNAs (siRNAs). Its tissue specificity may help explain the inefficiency of neuronal RNAi. (582 aa)
rsbp-1R-Seven Binding Protein (R7BP) homolog. (171 aa)
unc-119Protein unc-119; Myristoyl-binding protein that acts as a cargo adapter: specifically binds the myristoyl moiety of a subset of N-terminally myristoylated proteins and is required for their localization. Plays a key role in ciliary membrane localization of proteins. Required for the establishment or function of the nervous system. (244 aa)
cal-3CALmodulin related genes. (234 aa)
egl-30Heterotrimeric G protein alpha subunit. (355 aa)
myo-3Myosin-3; Essential for muscle contraction. Involved in ovulation likely by regulating the contraction of gonadal myoepithelial sheath cells. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1969 aa)
unc-43Calcium/calmodulin-dependent protein kinase type II; Acts in the signaling of a variety of pathways and processes. Phosphorylates 'Ser-319' of daf-16 in response to stress signals, such as heat, starvation and oxidation, which plays a role in prolonging lifespan. Required for viability under chronic osmotic stress in which it acts downstream of osr-1. Has roles in locomotion, oocyte maturation, brood size, egg laying, defecation, meiotic maturation and neuronal cell fate specification. Required for the regulation of synaptic density and neuromuscular junction morphology. Regulates the [...] (681 aa)
K03A1.4EF-hand domain-containing protein. (184 aa)
rgs-7Regulator of G-protein signaling rgs-7; Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunit egl-30 (G-alpha(q)), thereby driving it into its inactive GDP-bound form. May organize egl-30 into a stable multiprotein signaling complex, and thereby persistently inhibit egl-30 when triggered by calcium or phospholipids. (819 aa)
cal-7EF-hand domain-containing protein. (179 aa)
egl-10Regulator of G-protein signaling egl-10; Involved in egg-laying and locomotion. May regulate G protein goa-1 signaling. (639 aa)
flp-1FMRFamide-like neuropeptides 1; Together with flp-18, plays a homeostatic role by acting on the GABAergic neural transmission at neuromuscular junctions to prevent overexcitation of the locomotor circuit. DPNFLRF-amide: Inhibits the activity of dissected pharyngeal myogenic muscle system; Belongs to the FARP (FMRFamide related peptide) family. (175 aa)
grk-1G protein-coupled receptor kinase 1; Specifically phosphorylates the activated forms of G protein- coupled receptors; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (642 aa)
acy-1Adenylyl CYclase. (1253 aa)
acy-3Adenylyl CYclase. (1243 aa)
rgs-6Regulator of G-protein signaling rgs-6. (734 aa)
goa-1Guanine nucleotide-binding protein G(o) subunit alpha; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(o) protein function is not clear. In the 1-cell embryo, probably together with gpa-16, controls nuclear rotation and spindle elongation during mitosis. During the first embryonic cell divisions, plays a role in gpr-1/2 cortical localization and in the proper orientation of EMS blastomere mitotic spindle. Polarity determinants (par genes) may regulate lin- 5/gpr-1/gpr-2/goa-1 locally to create [...] (354 aa)
cal-2CALmodulin related genes. (171 aa)
eat-16Uncharacterized protein. (473 aa)
cmd-1Calmodulin; Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases. (149 aa)
kin-1cAMP-dependent protein kinase catalytic subunit; Essential for larval development. Controls the rhythmic contraction of enteric muscles probably by regulating G- protein coupled receptor aex-2-mediated calcium influx in GABAergic DVB neurons. Plays a role in the control of oocyte meiotic maturation by gonadal sheath cells. Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily. (579 aa)
lin-15BProtein lin-15B; Synthetic multivulva (synMuv) class B protein. SynMuv proteins are required to repress the induction of vulval development. Acts redundantly with SynMuv class A protein lin-15A to negatively regulate vulval development. Regulates let-23 basal activity. (1440 aa)
unc-17Vesicular acetylcholine transporter unc-17; Involved in acetylcholine transport into synaptic vesicles. Belongs to the major facilitator superfamily. Vesicular transporter family. (532 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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