STRINGSTRING
ced-2 ced-2 hgrs-1 hgrs-1 ced-10 ced-10 tiam-1 tiam-1 ehbp-1 ehbp-1 rab-5 rab-5 sand-1 sand-1 sdpn-1 sdpn-1 amph-1 amph-1 unc-119 unc-119 mig-14 mig-14 mom-5 mom-5 rab-10 rab-10 act-5 act-5 vha-6 vha-6 rab-7 rab-7 rme-1 rme-1 ced-12 ced-12 arf-6 arf-6 rabx-5 rabx-5 ced-1 ced-1 tbc-2 tbc-2 ZK970.8 ZK970.8
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ced-2Cell death abnormality protein 2; Required for cell migration and engulfment of cell corpses but not for programmed cell death/apoptosis. Has a role in the migration of the 2 gonadal distal tip cells (DTCs). (279 aa)
hgrs-1Hepatocyte Growth factor-Regulated TK Substrate (HRS) family. (729 aa)
ced-10Ras-related protein ced-10; Required in engulfing to control the phagocytosis of apoptotic cell corpses. Required in embryonic development for the correct positioning and orientation of the mitotic spindles and division planes in blastomere cells. Involved in hypodermal cell fusion, together with pak-1 and cdc-42, leading to embryonic body elongation, which involves dramatic cytoskeletal reorganization. ced-2 and ced-5 function to activate ced-10 in a GTPase signaling pathway that controls the polarized extension of cell surfaces. Plays a redundant role with mig-2 in dorsal axonal guid [...] (191 aa)
tiam-1DH domain-containing protein. (889 aa)
ehbp-1EH (Eps-15-homology) domain Binding Protein family. (901 aa)
rab-5RAB family. (208 aa)
sand-1SAND endocytosis protein family. (459 aa)
sdpn-1SynDaPiN (Synaptic dynamin binding protein) homolog. (495 aa)
amph-1AMPHiphysin homolog. (461 aa)
unc-119Protein unc-119; Myristoyl-binding protein that acts as a cargo adapter: specifically binds the myristoyl moiety of a subset of N-terminally myristoylated proteins and is required for their localization. Plays a key role in ciliary membrane localization of proteins. Required for the establishment or function of the nervous system. (244 aa)
mig-14Protein wntless homolog; Probable sorting receptor which regulates endocytosis and secretion of the wnt ligand egl-20. Recycling of mig-14 from the plasma membrane to the Golgi apparatus by the retromer complex is essential for its function. Its endosomal trafficking is regulated by its association with sorting nexin snx-3 on early endosomes and the mtm-6/mtm-9 myotubularin complex. Required in embryonic development for endoderm specification and the correct positioning and orientation of the mitotic spindles and division planes in blastomere cells. Functions during vulval development, [...] (549 aa)
mom-5Protein mom-5; Receptor for Wnt proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of gsk-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes (Probable). A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as pkc seems to be required for Wnt-mediated inactivation of gsk-3 kinase (Probable). B [...] (570 aa)
rab-10Ras-related protein Rab-10; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Required for basolateral endocytic recycling, the return of macromolecules and fluid from endosomes to the plasma membrane, in polarized epithelial cells of the intestine upstream of rm [...] (201 aa)
act-5ACTin. (375 aa)
vha-6V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (865 aa)
rab-7RAB family. (209 aa)
rme-1Receptor Mediated Endocytosis; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (791 aa)
ced-12Cell death abnormality protein 12; Involved in programmed apoptosis and necrosis. Required for the cell corpse engulfment process. Has roles in the formation of actin halos and distal tip cell migration. Negatively regulates the unc-6/Netrin receptor unc-5 to control distal tip cell migration along the anterior-posterior axis of the body. Plays no role in amphid axon outgrowth. (738 aa)
arf-6ADP-Ribosylation Factor related; Belongs to the small GTPase superfamily. Arf family. (175 aa)
rabx-5RAB eXchange factor. (517 aa)
ced-1Cell death abnormality protein 1; Involved in programmed cell death, also called apoptosis, in both somatic and germ cells. Acts by recruiting ced-6 to phagosomes which enables actin-dependent cytoskeletal reorganization and subsequent engulfment of the apoptotic cell corpse. Has a role in the association of ppk-3 and rab-7 with the phagosomal surface which is necessary for the incorporation of lysosomes to phagosomes during phagosome maturation. Activates the expression of unfolded protein response genes, which are involved in the immune response to live bacteria. (1111 aa)
tbc-2TBC (Tre-2/Bub2/Cdc16) domain family. (908 aa)
ZK970.8Uncharacterized protein. (143 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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