STRINGSTRING
lips-6 lips-6 atgl-1 atgl-1 acdh-2 acdh-2 nhr-74 nhr-74 acdh-13 acdh-13 acdh-5 acdh-5 scl-6 scl-6 C40H1.8 C40H1.8 sams-1 sams-1 djr-1.2 djr-1.2 spp-17 spp-17 acdh-1 acdh-1 maoc-1 maoc-1 acdh-12 acdh-12 pcyt-1 pcyt-1 far-3 far-3 nhr-117 nhr-117 ilys-5 ilys-5 cth-1 cth-1 F22E5.1 F22E5.1 acdh-9 acdh-9 oac-20 oac-20 folt-2 folt-2 pha-4 pha-4 pmt-2 pmt-2 klf-3 klf-3 egl-4 egl-4 clec-68 clec-68 acox-3 acox-3 swt-1 swt-1 acdh-8 acdh-8 acdh-3 acdh-3 K09H11.11 K09H11.11 nhr-49 nhr-49 asns-2 asns-2 dhs-28 dhs-28 acdh-10 acdh-10 acdh-4 acdh-4 cyp-34A1 cyp-34A1 lips-12 lips-12 T20B3.1 T20B3.1 lbp-8 lbp-8 acdh-7 acdh-7 lbp-5 lbp-5 fat-5 fat-5 sbp-1 sbp-1 Y48A6B.9 Y48A6B.9 Y53G8B.2 Y53G8B.2 daf-2 daf-2 daf-22 daf-22 nhr-244 nhr-244 cth-2 cth-2 lipl-5 lipl-5 pmt-1 pmt-1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
lips-6LIPaSe related. (344 aa)
atgl-1Patanin-like phospholipase domain-containing protein; Catalyzes the initial step in triglyceride hydrolysis in adipocyte and non-adipocyte lipid droplets (By similarity). May play a role in the response of the organism to starvation, enhancing hydrolysis of triglycerides and providing free fatty acids to other tissues to be oxidized in situations of energy depletion. Acts coordinately with lid-1 within the lipolytic cascade to distribute stored energy to tissues. Together with lipid droplet protein cgi-58, regulates lipid reserves as well as lipid droplet size and localization during t [...] (751 aa)
acdh-2Acyl CoA DeHydrogenase. (386 aa)
nhr-74Nuclear Hormone Receptor family. (316 aa)
acdh-13Acyl CoA DeHydrogenase. (617 aa)
acdh-5Acyl CoA DeHydrogenase. (442 aa)
scl-6SCP domain-containing protein; Belongs to the CRISP family. (209 aa)
C40H1.8Lipase_3 domain-containing protein. (342 aa)
sams-1Probable S-adenosylmethionine synthase 1; Catalyzes the formation of S-adenosylmethionine from methionine and ATP. The reaction comprises two steps that are both catalyzed by the same enzyme: formation of S-adenosylmethionine (AdoMet) and triphosphate, and subsequent hydrolysis of the triphosphate; Belongs to the AdoMet synthase family. (403 aa)
djr-1.2Glutathione-independent glyoxalase DJR-1.2; Catalyzes the conversion of methylglyoxal (MG) or glyoxal (GO) to D-lactate or glycolic acid respectively in a single glutathione (GSH)-independent step. May play a role in detoxifying endogenously produced glyoxals. Involved in protection against glyoxal-induced cell death. Protects dopaminergic neurons from glyoxal-dependent neuronal degeneration; Belongs to the peptidase C56 family. DJ-1 subfamily. (186 aa)
spp-17Saposin B-type domain-containing protein. (104 aa)
acdh-1Acyl CoA DeHydrogenase. (427 aa)
maoc-1MAO-C-like dehydratase domain. (298 aa)
acdh-12Acyl CoA DeHydrogenase. (613 aa)
pcyt-1Putative choline-phosphate cytidylyltransferase; Belongs to the cytidylyltransferase family. (362 aa)
far-3Fatty Acid/Retinol binding protein. (189 aa)
nhr-117Nuclear Hormone Receptor family. (477 aa)
ilys-5Invertebrate LYSozyme. (139 aa)
cth-1CystaTHionine gamma lyase. (392 aa)
F22E5.1Uncharacterized protein. (370 aa)
acdh-9Acyl CoA DeHydrogenase. (409 aa)
oac-20NRF domain-containing protein. (719 aa)
folt-2Folate-like transporter 2; Unlike folt-1, does not appear to act as a folate transporter; Belongs to the reduced folate carrier (RFC) transporter (TC 2.A.48) family. (424 aa)
pha-4Defective pharyngeal development protein 4; Acts as a transcription factor required for formation of the pharyngeal primordium. Binds to the consensus sequence 5'-T[AG]TT[TG][AG][TC]-3' with variations of the sequence affecting onset of target gene expression. Activates a wide array of pharyngeal genes including ceh-22 and myo-2 and represses ectodermal genes lin-26 and elt-3, ensuring pharyngeal cell fate. Required for recruitment of htz-1 to a subset of pharyngeal promoters to ensure gene activation and also acts synergistically with tbx-2 in pharyngeal development. Acts in the regul [...] (506 aa)
pmt-2Phosphoethanolamine MethylTransferase. (437 aa)
klf-3Kruppel-Like Factor (Zinc finger protein). (315 aa)
egl-4cGMP-dependent protein kinase egl-4; Promotes chemoreceptor gene expression in response to increased cGMP levels by antagonizing the gene repression functions of the class II HDAC hda-4 and the mef-2 transcription factor. Regulates gene expression via recruitment of a histone deacetylase complex containing hda-2, saeg-1 and saeg-2. Represses body size and lifespan through the dbl-1 and insulin pathways, respectively. May also signal through daf-3 and/or daf-5. Role in egg-laying, dauer formation and motility. Regulates behavioral responses to various chemosensory stimuli in sensory neu [...] (783 aa)
clec-68C-type lectin domain-containing protein. (462 aa)
acox-3Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. (667 aa)
swt-1Sugar transporter SWEET1; Mediates both low-affinity uptake and efflux of sugar across the membrane; Belongs to the SWEET sugar transporter family. (299 aa)
acdh-8Acyl CoA DeHydrogenase. (412 aa)
acdh-3Acyl CoA DeHydrogenase. (419 aa)
K09H11.11Uncharacterized protein. (74 aa)
nhr-49Nuclear hormone receptor family member nhr-49; Orphan nuclear receptor. Regulates expression of lipid desaturase, fat-7 ; Belongs to the nuclear hormone receptor family. (501 aa)
asns-2Glutamine amidotransferase type-2 domain-containing protein. (567 aa)
dhs-28SCP2 domain-containing protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (436 aa)
acdh-10Probable medium-chain specific acyl-CoA dehydrogenase 10, mitochondrial; This enzyme is specific for acyl chain lengths of 4 to 16. Belongs to the acyl-CoA dehydrogenase family. (417 aa)
acdh-4Acyl CoA DeHydrogenase. (385 aa)
cyp-34A1CYtochrome P450 family; Belongs to the cytochrome P450 family. (504 aa)
lips-12LIPaSe related. (277 aa)
T20B3.1Carn_acyltransf domain-containing protein. (608 aa)
lbp-8FABP domain-containing protein; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (137 aa)
acdh-7Acyl CoA DeHydrogenase. (412 aa)
lbp-5Fatty acid-binding protein homolog 5; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (136 aa)
fat-5Delta(9)-fatty-acid desaturase fat-5; Delta(9)-fatty-acid desaturase that acts preferentially on palmitoyl-CoA. Also acts on pentadecanoyl-coA and myristoyl-CoA. (333 aa)
sbp-1BHLH domain-containing protein. (1113 aa)
Y48A6B.9Enoyl-[acyl-carrier-protein] reductase, mitochondrial; Catalyzes the NADPH-dependent reduction of trans-2-enoyl thioesters in mitochondrial fatty acid synthesis (fatty acid synthesis type II). Fatty acid chain elongation in mitochondria uses acyl carrier protein (ACP) as an acyl group carrier, but the enzyme accepts both ACP and CoA thioesters as substrates in vitro. Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily. (346 aa)
Y53G8B.2Uncharacterized protein. (340 aa)
daf-2Insulin-like receptor subunit alpha; Insulin receptor-like tyrosine kinase which regulates metabolism, controls longevity and prevents developmental arrest at the dauer stage. Binding of INS family members may either stimulate, or antagonize, association of the receptor with downstream mediators such as pdk-1 and age-1. Required for germline progenitor proliferation during larval development. Required for the response to environmental stimuli such as food, pheromone, and temperature. Negatively regulates resistance to UV and oxidative stress. Role in immune function and pathogen resist [...] (1928 aa)
daf-22Non-specific lipid-transfer protein-like 2; Catalyzes the thiolytic cleavage of 3-ketoacyl-CoA with 8-16 carbon residues in the acyl group using a ping-pong mechanism whereby binding to 3-ketooctanoyl-CoA results in the release of acetyl-CoA and the subsequent addition of CoA produces 3-ketohexanohyl-CoA. Involved in the biosynthesis of the dauer pheromone by providing short chains of fatty acid that are attached to the ascarylose sugars of the pheromone. Belongs to the thiolase-like superfamily. Thiolase family. (412 aa)
nhr-244NR LBD domain-containing protein. (173 aa)
cth-2Putative cystathionine gamma-lyase 2; Belongs to the trans-sulfuration enzymes family. (392 aa)
lipl-5Lipase; Belongs to the AB hydrolase superfamily. Lipase family. (403 aa)
pmt-1Methyltransf_11 domain-containing protein. (484 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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