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acy-2 acy-2 flp-17 flp-17 nmur-1 nmur-1 egl-19 egl-19 egl-6 egl-6 gcy-36 gcy-36 acy-3 acy-3 npr-1 npr-1 glc-4 glc-4 frpr-3 frpr-3 flp-21 flp-21 goa-1 goa-1 npr-11 npr-11 glb-5 glb-5 seb-3 seb-3 npr-4 npr-4 pld-1 pld-1 npr-3 npr-3 gpc-2 gpc-2 pdfr-1 pdfr-1 gcy-35 gcy-35 pdf-1 pdf-1 ntr-1 ntr-1 egl-8 egl-8 nlp-1 nlp-1 gsa-1 gsa-1 egl-30 egl-30 nlp-12 nlp-12 unc-68 unc-68 nmur-2 nmur-2 gpc-1 gpc-1 gnrr-1 gnrr-1 gpb-2 gpb-2 nlp-37 nlp-37 npr-6 npr-6 ntc-1 ntc-1 nlp-47 nlp-47 tax-2 tax-2 flp-10 flp-10 itr-1 itr-1 gpa-12 gpa-12 acy-1 acy-1 ntr-2 ntr-2 gpb-1 gpb-1 ins-1 ins-1 ZK970.8 ZK970.8 kin-1 kin-1 unc-13 unc-13 tax-4 tax-4 glc-3 glc-3 npr-5 npr-5 flp-18 flp-18 ckr-1 ckr-1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
acy-2Adenylyl CYclase; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1080 aa)
flp-17FMRF-Like Peptide. (130 aa)
nmur-1G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (400 aa)
egl-19Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1877 aa)
egl-6G_PROTEIN_RECEP_F1_2 domain-containing protein. (395 aa)
gcy-36Soluble guanylate cyclase gcy-36; Plays a central role in social feeding behavior by synthesizing 3',5'-cyclic guanosine monophosphate (cGMP) from GTP. Oxygen, which probably binds to its heme-binding sites, may regulate social behavior by modulating its activity. cGMP is a common second messenger in sensory transduction and is implicated in oxygen sensation. Indeed, C.elegans exhibits a strong behavioral preference for 5-12% oxygen, avoiding higher and lower oxygen levels; a higher level of oxygen inducing a naturally polymorphic social feeding behavior. Involved in avoidance of hyper [...] (675 aa)
acy-3Adenylyl CYclase. (1243 aa)
npr-1G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (457 aa)
glc-4Glutamate-gated ChLoride channel; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (500 aa)
frpr-3G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (360 aa)
flp-21FMRF-Like Peptide. (66 aa)
goa-1Guanine nucleotide-binding protein G(o) subunit alpha; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(o) protein function is not clear. In the 1-cell embryo, probably together with gpa-16, controls nuclear rotation and spindle elongation during mitosis. During the first embryonic cell divisions, plays a role in gpr-1/2 cortical localization and in the proper orientation of EMS blastomere mitotic spindle. Polarity determinants (par genes) may regulate lin- 5/gpr-1/gpr-2/goa-1 locally to create [...] (354 aa)
npr-11Putative neuropeptide Y receptor 11; Could be a receptor for neuropeptide Y and peptide YY; Belongs to the G-protein coupled receptor 1 family. (402 aa)
glb-5GLOBIN domain-containing protein; Belongs to the globin family. (397 aa)
seb-3Secretin receptor-like protein SEB-3; Belongs to the G-protein coupled receptor 2 family. (454 aa)
npr-4G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (490 aa)
pld-1Phospholipase. (1427 aa)
npr-3G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (376 aa)
gpc-2G protein gamma domain-containing protein. (62 aa)
pdfr-1Calcitonin receptor-like protein 1; G-protein coupled receptor for PDF neuropeptides. Activated by peptides PDF-1 and PDF-2 but to a lesser extent with isoform c. Isoforms a and b are thought to act through the G-alpha(s) type of G proteins to elevate cAMP levels whereas isoform c inhibits cAMP levels through the G-alpha(i/o) type of G proteins. Involved in locomotion; more specifically mate searching behavior independent of nutritional status. Might have a role in touch sensitivity. (546 aa)
gcy-35Soluble guanylate cyclase gcy-35; Plays a central role in social feeding behavior and oxygen sensation by synthesizing 3',5'-cyclic guanosine monophosphate (cGMP) from GTP. Oxygen, which binds to its heme-binding sites, probably regulates social behavior by modulating its activity. cGMP is a common second messenger in sensory transduction and is implicated in oxygen sensation. Indeed, C.elegans exhibits a strong behavioral preference for 5-12% oxygen, avoiding higher and lower oxygen levels; a higher level of oxygen inducing a naturally polymorphic social feeding behavior. Involved in [...] (688 aa)
pdf-1PDF (Arthropod Pigment Dispersing Factor) homolog. (88 aa)
ntr-1Nematocin receptor 1; Receptor for nematocin. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. The activity of this receptor may be modulated by ntr-2, leading to reduced intracellular cAMP production. Plays a role in gustatory associative learning. Also plays a role in male mating behavior ; Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (379 aa)
egl-81-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta egl-8; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) which plays an important role in the regulation of intracellular signaling cascades (By similarity). Required in the nervous system to modulate neuronal activity. Facilitates synaptic transmission at neuromuscular junctions by regulating the release of acetylcholine from the motor neurons and thus affecting locomotion. Plays a role in efficient egg laying and defecation. Involved in axon regeneration [...] (1512 aa)
nlp-1Neuropeptide-like protein 1; In AWC olfactory sensory neurons, required for the detection of preferred food sources. (176 aa)
gsa-1G protein, Subunit Alpha. (378 aa)
egl-30Heterotrimeric G protein alpha subunit. (355 aa)
nlp-12Neuropeptide-Like Protein. (80 aa)
unc-68Uncharacterized protein. (5202 aa)
nmur-2G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (403 aa)
gpc-1Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (62 aa)
gnrr-1G_PROTEIN_RECEP_F1_2 domain-containing protein. (401 aa)
gpb-2Guanine nucleotide-binding protein subunit beta-2; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (369 aa)
nlp-37PDF (Arthropod Pigment Dispersing Factor) homolog. (89 aa)
npr-6G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (402 aa)
ntc-1Nematocin; Ligand for the G-protein coupled receptor ntr-1. Plays a role in gustatory associative learning. Also plays a role in male mating behavior. (103 aa)
nlp-47Neuropeptide-Like Protein. (89 aa)
tax-2Cyclic nucleotide-binding domain-containing protein. (800 aa)
flp-10FMRFamide-like peptide 10. (67 aa)
itr-1Inositol 1,4,5-trisphosphate receptor itr-1; Receptor for inositol 1,4,5-trisphosphate, a second messenger that regulates intracellular calcium homeostasis. Binds in vitro to both inositol 1,4,5-trisphosphate (1,4,5-InsP3) and inositol 2,4,5-trisphosphate (2,4,5-InsP3) with high affinity and does not discriminate between the phosphate at 1 or 2 position. Can also bind inositol 1,3,4,5-tetrakisphosphate (1,3,4,5-InsP4) and inositol 4,5-bisphosphate (4,5-InsP2), but with lower affinity. Acts as a timekeeper/rhythm generator via calcium signaling, affecting the defecation cycle and pharyn [...] (2892 aa)
gpa-12Guanine nucleotide-binding protein alpha-12 subunit; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems (Probable). May play a role in resistance to fungal infection in the epidermis by regulating the up-regulation of several antimicrobial peptides of the NLP and CNC families. Upstream of plc-3, tpa-1 and the p38-like pathway, required for the expression of antimicrobial peptide nlp-29 in the epidermis in response to fungal infection or physical injury. (355 aa)
acy-1Adenylyl CYclase. (1253 aa)
ntr-2Nematocin receptor 2; Not directly activated by nematocin. May modulate activity of the nematocin receptor ntr- 1, leading to reduced intracellular cAMP production. Plays a role in male mating behavior. Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (398 aa)
gpb-1Guanine nucleotide-binding protein subunit beta-1; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. In the early embryo, controls the magnitude of the forces acting on centrosomes but is not required for generating asymmetric forces. (340 aa)
ins-1IlGF domain-containing protein. (109 aa)
ZK970.8Uncharacterized protein. (143 aa)
kin-1cAMP-dependent protein kinase catalytic subunit; Essential for larval development. Controls the rhythmic contraction of enteric muscles probably by regulating G- protein coupled receptor aex-2-mediated calcium influx in GABAergic DVB neurons. Plays a role in the control of oocyte meiotic maturation by gonadal sheath cells. Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily. (579 aa)
unc-13Phorbol ester/diacylglycerol-binding protein unc-13; May form part of a signal transduction pathway, transducing the signal from diacylglycerol to effector functions. One such function could be the release of neurotransmitter from neurons. Probably by regulating neuronal transmission downstream of lin-3 and receptor lin-23 and phospholipase plc-3 and upstream of innexin unc-7 and egl-4/PKG in ALA neurons, involved in the decrease in pharyngeal pumping during the quiescent state that precedes each larval molt. (2155 aa)
tax-4Cyclic nucleotide-gated cation channel; Required for normal thermosensation and chemosensation sensory behavior. Required, downstream of receptor- type guanylate cyclase gcy-9, for CO2-mediated responses in BAG neurons. Required, downstream of receptor-type guanylate cyclase gcy-14, for alkaline pH-mediated responses in ASE-left (ASEL) neurons. Involved in the development of ASJ sensory neuron axon during late larval stages and in the maintenance of normal axon morphology in the adult. Regulates dauer formation. Required for the calcium flux to the cytoplasm in the ASJ sensory neurons [...] (733 aa)
glc-3Glutamate-gated chloride channel subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (484 aa)
npr-5G_PROTEIN_RECEP_F1_2 domain-containing protein. (433 aa)
flp-18FMRFamide-like neuropeptide 18; Together with flp-1, plays a homeostatic role by acting on the GABAergic neural transmission at neuromuscular junctions to prevent overexcitation of the locomotor circuit. Plays a role in the navigational capacity of sperm and the targeting of sperm derived from males to the fertilization site in the uterus of hermaphrodites. [EMPGVLRF-amide]: Inhibits the activity of dissected pharyngeal myogenic muscle system. (208 aa)
ckr-1G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (421 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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