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cpna-2 | Copine family protein 2; Belongs to the copine family. (7705 aa) | ||||
scpl-1 | CTD small phosphatase-like protein 1; Phosphatase which may play a role in the egg laying muscles. (491 aa) | ||||
cpna-5 | Copine family protein 5. (717 aa) | ||||
unc-89 | Muscle M-line assembly protein unc-89; Structural component of the muscle M line which is involved in assembly and organization of sarcomere myofilaments. The large isoform a, isoform b, isoform d and isoform f play an essential role in maintaining the organization of sarcomeres but not myofilament alignment during body wall muscle development whereas the small isoform c and isoform d appear to have a minor role. Isoform b and isoform f are required for the organization of unc-15/paramyosin into sarcomere thick filaments in body wall muscles. By binding mel-26, a substrate adapter of t [...] (8081 aa) | ||||
pat-4 | Integrin-linked protein kinase homolog pat-4; Probable pseudokinase that acts as an adapter protein. Component of an integrin containing attachment complex, which is required for muscle development and maintenance. Involved in the assembly of dense bodies and M lines during body wall muscle development by recruiting several of their components including integrin pat-3, cpna-1, unc-89 and unc- 112 to integrin-mediated attachment sites. Plays a role in distal tip cell (DTC) migration and in oocyte development probably by regulating the actin cytoskeleton. During the formation of neuromus [...] (466 aa) | ||||
unc-112 | Protein unc-112; Component of an integrin containing attachment complex, which is required for muscle development and maintenance. Probable regulator of cell-extracellular matrix adhesion. Required during initial muscle assembly to form dense bodies and M-lines. (720 aa) | ||||
glp-1 | Protein glp-1; Involved in the specification of the cell fates of the blastomeres, ABa and APa. Proper signaling by glp-1 induces ABa descendants to produce anterior pharyngeal cells, and APa descendants to adopt a different fate. Contributes to the establishment of the dorsal-ventral axis in early embryos. Regulates germ cell mitotic proliferation probably by regulating MAP kinase phosphatase lip-1 expression. Plays a negative role in lifespan. (1295 aa) | ||||
unc-54 | Myosin-4; Required for muscle contraction. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1963 aa) | ||||
unc-96 | Uncharacterized protein. (418 aa) | ||||
unc-97 | LIM domain-containing protein unc-97; Component of an integrin containing attachment complex, which is required for muscle development and maintenance. Probably function in adherens junction. Affects the structural integrity of the integrin containing muscle adherens junctions and contributes to the mechanosensory functions of touch neurons. (348 aa) | ||||
dpy-19 | C-mannosyltransferase dpy-19; C-mannosyltransferase that mediates C-mannosylation of tryptophan residues on target proteins such as unc-5 and mig-21. Mediates the attachment of alpha-mannose in C-C linkage to the C2 of the indole ring of tryptophan. C-mannosylation takes place in the endoplasmic reticulum and frequently found in thrombospondin (TSP) type-1 repeats and in the WSXWS motif of type I cytokine receptors. Required to orient neuroblasts QL and QR correctly on the anterior/posterior (A/P) axis: QL and QR are born in the same A/P position, but polarize and migrate left/right as [...] (683 aa) | ||||
lim-9 | LIM domain family. (793 aa) | ||||
cpna-1 | Copine family protein 1; Involved in the assembly of dense bodies and M lines during body wall muscle development. Acts by recruiting downstream of integrin-associated protein pat-6/actopaxin several dense bodies and M line components including unc-89, lim-9, scpl-1 and unc-96 to integrin- mediated attachment sites. (1107 aa) | ||||
ketn-1 | KETtiN (Drosophila actin-binding) homolog. (4963 aa) | ||||
pat-2 | Integrin alpha pat-2; Required for muscle development probably through the regulation of the actin-myosin cytoskeleton. Component of an integrin containing attachment complex, which is required for muscle maintenance. During the formation of neuromuscular junctions at the larval stage, negatively regulates membrane protrusion from body wall muscles, probably through lamins such as epi-1, lam-2 and unc-52. Required for distal tip cell migration and dorsal pathfinding. Required for egg-laying. May play a role in cell motility and cell-cell interactions (By similarity). Plays a role in vu [...] (1226 aa) | ||||
vig-1 | HABP4_PAI-RBP1 domain-containing protein. (378 aa) | ||||
myo-3 | Myosin-3; Essential for muscle contraction. Involved in ovulation likely by regulating the contraction of gonadal myoepithelial sheath cells. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1969 aa) | ||||
rol-6 | Cuticle collagen rol-6; Nematode cuticles are composed largely of collagen-like proteins. The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment. Involved in body morphogenesis. (348 aa) | ||||
gem-4 | Gon-2 Extragenic Modifier. (625 aa) | ||||
dpy-10 | Cuticle collagen dpy-10; Nematode cuticles are composed largely of collagen-like proteins. The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment. (356 aa) | ||||
dpy-9 | Col_cuticle_N domain-containing protein. (315 aa) | ||||
pat-6 | Paralyzed arrest at two-fold protein 6; Involved in the regulation of cell adhesion and cytoskeleton organization. Component of an integrin containing attachment complex, which is required for muscle development and maintenance. During embryonic development, required to recruit cpna-1, unc-89 and myofilaments to newly forming integrin attachments composed of integrins pat-2/pat-3, pat-4 and unc-112. Also required to reposition the integrin-based attachments so that they form the highly ordered array of dense body and M-line attachments that are characteristic of mature muscle cells. Du [...] (375 aa) | ||||
act-5 | ACTin. (375 aa) | ||||
nra-1 | Nicotinic receptor-associated protein 1; Exhibits calcium-dependent phospholipid binding properties (By similarity). May function in membrane trafficking. Regulates synaptic levels of nicotinic acetylcholine receptor subunit lev-1 and unc-38 in the nerve cord. Involved in nicotinic acetylcholine receptor (nAChR)-mediated sensitivity to nicotine and levamisole. Affects directional sperm motility. (634 aa) | ||||
atn-1 | AcTiniN. (920 aa) | ||||
cpna-4 | Copine domain-containing protein. (610 aa) | ||||
unc-52 | Basement membrane proteoglycan; Component of an integrin containing attachment complex, which is required for muscle development and maintenance. Probable structural role in myofilament assembly and/or attachment of the myofilament lattice to the cell membrane. May be an extracellular anchor for integrin receptors in body wall muscles and myoepithelial sheath cells. During the formation of neuromuscular junctions at the larval stage, negatively regulates membrane protrusion from body wall muscles, probably downstream of the integrin complex formed by pat-2 and pat-3. Involved in ovulation. (3375 aa) | ||||
deb-1 | Vinculin; Involved in cell adhesion. May be involved in the attachment of the actin-based microfilaments to the plasma membrane. Involved in ovulation. (1090 aa) | ||||
pat-3 | Integrin beta pat-3; Integrin alpha ina-1/beta pat-3 is a receptor for laminin. Integrin alpha pat-2/beta pat-3 recognizes the sequence R-G-D in its ligands (Probable). Plays a role in cell migration, morphogenesis and probably in cell-cell interactions. During gonad morphogenesis, involved in distal tip cell (DTC)-mediated guidance of gonad elongation, in maintaining their sharp tapering morphology and in their migration. Component of an integrin containing attachment complex, which is required for muscle development and maintenance. Involved in the assembly of dense bodies and M line [...] (809 aa) | ||||
mel-26 | Protein maternal effect lethal 26; Probable substrate-specific adapter of an E3 ubiquitin- protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Controls degradation of microtubule severing protein mei-1 after meiosis. Controls degradation of ppfr-1, the regulatory subunit of PP4 complex, after meiosis. In body wall muscles, involved in the organization of myosin thick filaments, likely by regulating the degradation of mei-1 downstream of unc-89. May also activate the TORC1 pathway. (399 aa) |