node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Y73B6BL.12 | act-5 | Y73B6BL.12.1 | T25C8.2.2 | Thioredoxin; Belongs to the thioredoxin family. | ACTin. | 0.668 |
Y73B6BL.12 | cmd-1 | Y73B6BL.12.1 | T21H3.3a.1 | Thioredoxin; Belongs to the thioredoxin family. | Calmodulin; Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases. | 0.484 |
Y73B6BL.12 | trx-4 | Y73B6BL.12.1 | Y44E3A.3.1 | Thioredoxin; Belongs to the thioredoxin family. | Thioredoxin; Belongs to the thioredoxin family. | 0.621 |
act-5 | Y73B6BL.12 | T25C8.2.2 | Y73B6BL.12.1 | ACTin. | Thioredoxin; Belongs to the thioredoxin family. | 0.668 |
act-5 | cdk-5 | T25C8.2.2 | T27E9.3.1 | ACTin. | Cyclin-dependent-like kinase 5; Proline-directed serine/threonine-protein kinase which, in several motor neurons, promotes the polarized trafficking of synaptic vesicles and dense-core vesicles (DCV). In the ventral nerve cord, phosphorylates lin-10 and thereby prevents lin-10-mediated anterograde trafficking of the glutamate receptor glr-1. Involved in the inhibition of glr-1 trafficking in hypoxic conditions. In DA motor neurons but not in DB motor neurons, regulates axonal transport of synaptic vesicle precursors by inhibiting dynein-mediated retrograde transport. Regulates the traf [...] | 0.820 |
act-5 | cmd-1 | T25C8.2.2 | T21H3.3a.1 | ACTin. | Calmodulin; Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases. | 0.937 |
act-5 | klc-1 | T25C8.2.2 | M7.2b.1 | ACTin. | TPR_REGION domain-containing protein. | 0.828 |
act-5 | num-1 | T25C8.2.2 | T03D8.1d.1 | ACTin. | Numb-related protein 1; Involved in the tethering and targeting of pkc-3 to modulate the intracellular distribution of the kinase. The complex formed with pkc-3 complexes are likely to be involved in assembly, maintenance, and/or regulation of protein complexes that execute asymmetric and/or polarized cell functions. | 0.779 |
act-5 | plx-1 | T25C8.2.2 | Y55F3AL.1b.1 | ACTin. | Sema domain-containing protein. | 0.703 |
act-5 | trx-4 | T25C8.2.2 | Y44E3A.3.1 | ACTin. | Thioredoxin; Belongs to the thioredoxin family. | 0.684 |
act-5 | unc-33 | T25C8.2.2 | Y37E11C.1a.1 | ACTin. | Protein unc-33; During neurogenesis, plays an essential role in axonal guidance and outgrowth by regulating the polarization of both microtubule and actin cytoskeletons. Establishes the asymmetry of axonal and dendrite microtubules and the polarized sorting of neuronal proteins. This is achieved in part by regulating the localization of kinesin-like protein unc-104. In neurons without a distal microtubule- organizing center (MTOC), also controls the organization of microtubules in dendrites. During the dorso-ventral axonal guidance and outgrowth of VD neurons, required downstream of Ra [...] | 0.558 |
cdk-5 | act-5 | T27E9.3.1 | T25C8.2.2 | Cyclin-dependent-like kinase 5; Proline-directed serine/threonine-protein kinase which, in several motor neurons, promotes the polarized trafficking of synaptic vesicles and dense-core vesicles (DCV). In the ventral nerve cord, phosphorylates lin-10 and thereby prevents lin-10-mediated anterograde trafficking of the glutamate receptor glr-1. Involved in the inhibition of glr-1 trafficking in hypoxic conditions. In DA motor neurons but not in DB motor neurons, regulates axonal transport of synaptic vesicle precursors by inhibiting dynein-mediated retrograde transport. Regulates the traf [...] | ACTin. | 0.820 |
cdk-5 | cmd-1 | T27E9.3.1 | T21H3.3a.1 | Cyclin-dependent-like kinase 5; Proline-directed serine/threonine-protein kinase which, in several motor neurons, promotes the polarized trafficking of synaptic vesicles and dense-core vesicles (DCV). In the ventral nerve cord, phosphorylates lin-10 and thereby prevents lin-10-mediated anterograde trafficking of the glutamate receptor glr-1. Involved in the inhibition of glr-1 trafficking in hypoxic conditions. In DA motor neurons but not in DB motor neurons, regulates axonal transport of synaptic vesicle precursors by inhibiting dynein-mediated retrograde transport. Regulates the traf [...] | Calmodulin; Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases. | 0.737 |
cdk-5 | klc-1 | T27E9.3.1 | M7.2b.1 | Cyclin-dependent-like kinase 5; Proline-directed serine/threonine-protein kinase which, in several motor neurons, promotes the polarized trafficking of synaptic vesicles and dense-core vesicles (DCV). In the ventral nerve cord, phosphorylates lin-10 and thereby prevents lin-10-mediated anterograde trafficking of the glutamate receptor glr-1. Involved in the inhibition of glr-1 trafficking in hypoxic conditions. In DA motor neurons but not in DB motor neurons, regulates axonal transport of synaptic vesicle precursors by inhibiting dynein-mediated retrograde transport. Regulates the traf [...] | TPR_REGION domain-containing protein. | 0.568 |
cdk-5 | plx-1 | T27E9.3.1 | Y55F3AL.1b.1 | Cyclin-dependent-like kinase 5; Proline-directed serine/threonine-protein kinase which, in several motor neurons, promotes the polarized trafficking of synaptic vesicles and dense-core vesicles (DCV). In the ventral nerve cord, phosphorylates lin-10 and thereby prevents lin-10-mediated anterograde trafficking of the glutamate receptor glr-1. Involved in the inhibition of glr-1 trafficking in hypoxic conditions. In DA motor neurons but not in DB motor neurons, regulates axonal transport of synaptic vesicle precursors by inhibiting dynein-mediated retrograde transport. Regulates the traf [...] | Sema domain-containing protein. | 0.684 |
cdk-5 | plx-2 | T27E9.3.1 | K04B12.1.1 | Cyclin-dependent-like kinase 5; Proline-directed serine/threonine-protein kinase which, in several motor neurons, promotes the polarized trafficking of synaptic vesicles and dense-core vesicles (DCV). In the ventral nerve cord, phosphorylates lin-10 and thereby prevents lin-10-mediated anterograde trafficking of the glutamate receptor glr-1. Involved in the inhibition of glr-1 trafficking in hypoxic conditions. In DA motor neurons but not in DB motor neurons, regulates axonal transport of synaptic vesicle precursors by inhibiting dynein-mediated retrograde transport. Regulates the traf [...] | Plexin-2; Involved as a receptor for mab-20/sema-2a in the formation or stabilization of cell-cell contacts at several stages of epithelial morphogenesis. In early embryonic development, required for proper ventral closure of the epidermis. During male tail morphogenesis, involved in precursor cell sorting and in the formation of distinct sensory rays. Involved in axon guidance of SDQL neurons during neurogenesis. Probably in response to stimulation by mab-20, regulates fln-1-mediated remodeling of the actin cytoskeleton and thus axon guidance and/or fasciculation of DD/VD neurons. Bel [...] | 0.666 |
cdk-5 | unc-33 | T27E9.3.1 | Y37E11C.1a.1 | Cyclin-dependent-like kinase 5; Proline-directed serine/threonine-protein kinase which, in several motor neurons, promotes the polarized trafficking of synaptic vesicles and dense-core vesicles (DCV). In the ventral nerve cord, phosphorylates lin-10 and thereby prevents lin-10-mediated anterograde trafficking of the glutamate receptor glr-1. Involved in the inhibition of glr-1 trafficking in hypoxic conditions. In DA motor neurons but not in DB motor neurons, regulates axonal transport of synaptic vesicle precursors by inhibiting dynein-mediated retrograde transport. Regulates the traf [...] | Protein unc-33; During neurogenesis, plays an essential role in axonal guidance and outgrowth by regulating the polarization of both microtubule and actin cytoskeletons. Establishes the asymmetry of axonal and dendrite microtubules and the polarized sorting of neuronal proteins. This is achieved in part by regulating the localization of kinesin-like protein unc-104. In neurons without a distal microtubule- organizing center (MTOC), also controls the organization of microtubules in dendrites. During the dorso-ventral axonal guidance and outgrowth of VD neurons, required downstream of Ra [...] | 0.714 |
chin-1 | cmd-1 | BE0003N10.2.1 | T21H3.3a.1 | CHImaeriN (Rac-GTPase-activating protein) homolog. | Calmodulin; Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases. | 0.478 |
chin-1 | klc-1 | BE0003N10.2.1 | M7.2b.1 | CHImaeriN (Rac-GTPase-activating protein) homolog. | TPR_REGION domain-containing protein. | 0.573 |
chin-1 | plx-1 | BE0003N10.2.1 | Y55F3AL.1b.1 | CHImaeriN (Rac-GTPase-activating protein) homolog. | Sema domain-containing protein. | 0.699 |