STRINGSTRING
usp-46 usp-46 ZK970.8 ZK970.8 mig-1 mig-1 usp-5 usp-5 glr-1 glr-1 usp-14 usp-14 rab-5 rab-5 math-33 math-33 rpn-11 rpn-11
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
usp-46Ubiquitin carboxyl-terminal hydrolase 46; Regulates the abundance of the glr-1 glutamate receptor in the ventral nerve cord by promoting its deubiquitination and preventing its degradation in the lysosome. Contributes to the regulation of embryonic polarity. (426 aa)
ZK970.8Uncharacterized protein. (143 aa)
mig-1Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (529 aa)
usp-5Ubiquitin carboxyl-terminal hydrolase. (789 aa)
glr-1Glutamate receptor 1; Non-NMDA (N-methyl-D-aspartate) ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of glutamate are mediated by a variety of receptors that are named according to their selective agonists. May contribute to a sensory discrimination between mechanical and chemical stimuli. Plays a role in controlling movement in response to environmental cues such as food availability and mechanosensory stimulation such as the nose touch response. In AIB interneurons, promotes om [...] (962 aa)
usp-14Ubiquitin carboxyl-terminal hydrolase 14; Proteasome-associated deubiquitinase which releases ubiquitin from the proteasome targeted ubiquitinated proteins. Ensures the regeneration of ubiquitin at the proteasome (By similarity). Belongs to the peptidase C19 family. USP14/UBP6 subfamily. (489 aa)
rab-5RAB family. (208 aa)
math-33Ubiquitin carboxyl-terminal hydrolase 7; Hydrolase that deubiquitinates target proteins. (1138 aa)
rpn-1126S proteasome non-ATPase regulatory subunit 14; Metalloprotease component of the 26S proteasome that specifically cleaves 'Lys-63'-linked polyubiquitin chains. The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The function of the 'Lys-63'-specific deubiquitination of the proteasome is unclear (By similarity). (312 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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