STRINGSTRING
F42H10.3 F42H10.3 ZK970.8 ZK970.8 mel-26 mel-26 cdc-42 cdc-42 scpl-1 scpl-1 B0511.6 B0511.6 unc-89 unc-89 dim-1 dim-1 pxl-1 pxl-1 pat-4 pat-4 kin-32 kin-32 dyc-1 dyc-1 unc-112 unc-112 pas-2 pas-2 mec-3 mec-3 pcyt-1 pcyt-1 unc-96 unc-96 unc-97 unc-97 dys-1 dys-1 lim-9 lim-9 lim-8 lim-8 unc-45 unc-45 uig-1 uig-1 zyx-1 zyx-1 pos-1 pos-1 deb-1 deb-1 lin-11 lin-11 tln-1 tln-1 pola-1 pola-1 Y37B11A.2 Y37B11A.2 Y23H5B.6 Y23H5B.6 unc-95 unc-95 atn-1 atn-1 act-5 act-5 pat-6 pat-6 alp-1 alp-1 hum-6 hum-6 mlp-1 mlp-1 T03G6.3 T03G6.3 mei-1 mei-1 spi-1 spi-1 sti-1 sti-1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
F42H10.3LIM and SH3 domain protein F42H10.3. (335 aa)
ZK970.8Uncharacterized protein. (143 aa)
mel-26Protein maternal effect lethal 26; Probable substrate-specific adapter of an E3 ubiquitin- protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Controls degradation of microtubule severing protein mei-1 after meiosis. Controls degradation of ppfr-1, the regulatory subunit of PP4 complex, after meiosis. In body wall muscles, involved in the organization of myosin thick filaments, likely by regulating the degradation of mei-1 downstream of unc-89. May also activate the TORC1 pathway. (399 aa)
cdc-42Cell division control protein 42 homolog; Plays an essential role in spindle orientation and organizing cellular and embryonic polarity by controlling the localization and activity of PAR (partitioning-defective) proteins. Required for maintaining the asymmetric cortical localization of the anterior complex proteins par-3 and par-6, the posterior cortical protein par-2, and pkc-3. Involved in hypodermal cell fusion, together with pak-1 and ced-10, leading to embryonic body elongation, which involves dramatic cytoskeletal reorganization. During gonad morphogenesis, plays a role in dista [...] (191 aa)
scpl-1CTD small phosphatase-like protein 1; Phosphatase which may play a role in the egg laying muscles. (491 aa)
B0511.6RNA helicase. (544 aa)
unc-89Muscle M-line assembly protein unc-89; Structural component of the muscle M line which is involved in assembly and organization of sarcomere myofilaments. The large isoform a, isoform b, isoform d and isoform f play an essential role in maintaining the organization of sarcomeres but not myofilament alignment during body wall muscle development whereas the small isoform c and isoform d appear to have a minor role. Isoform b and isoform f are required for the organization of unc-15/paramyosin into sarcomere thick filaments in body wall muscles. By binding mel-26, a substrate adapter of t [...] (8081 aa)
dim-1Disorganized muscle protein 1; Stabilizes the attachment of the myofilament lattice to the muscle cell membrane. Isoform b is sufficient for wild-type function. (640 aa)
pxl-1Paxillin homolog 1; Required for myofilament organization of the pharyngeal sarcomeres and for pharyngeal muscle contractions and hence for pharyngeal pumping. Together with lin-8, might be required for myofilament organization in the body wall muscles ; Belongs to the paxillin family. (413 aa)
pat-4Integrin-linked protein kinase homolog pat-4; Probable pseudokinase that acts as an adapter protein. Component of an integrin containing attachment complex, which is required for muscle development and maintenance. Involved in the assembly of dense bodies and M lines during body wall muscle development by recruiting several of their components including integrin pat-3, cpna-1, unc-89 and unc- 112 to integrin-mediated attachment sites. Plays a role in distal tip cell (DTC) migration and in oocyte development probably by regulating the actin cytoskeleton. During the formation of neuromus [...] (466 aa)
kin-32Inactive tyrosine-protein kinase kin-32; Has apparently no tyrosine kinase activity in vitro when expressed in mammalian cells; Belongs to the protein kinase superfamily. Tyr protein kinase family. FAK subfamily. (867 aa)
dyc-1Dystrophin-like protein 1; Together with dys-1 and hlh-1, participates in a common muscular function. (887 aa)
unc-112Protein unc-112; Component of an integrin containing attachment complex, which is required for muscle development and maintenance. Probable regulator of cell-extracellular matrix adhesion. Required during initial muscle assembly to form dense bodies and M-lines. (720 aa)
pas-2Proteasome subunit alpha type-2; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity). (231 aa)
mec-3Mechanosensory protein 3; Specifies differentiation of the set of six touch receptor neurons. Binds cooperatively as a heterodimer with unc-86 to sites in the mec-3 gene promoter. (321 aa)
pcyt-1Putative choline-phosphate cytidylyltransferase; Belongs to the cytidylyltransferase family. (362 aa)
unc-96Uncharacterized protein. (418 aa)
unc-97LIM domain-containing protein unc-97; Component of an integrin containing attachment complex, which is required for muscle development and maintenance. Probably function in adherens junction. Affects the structural integrity of the integrin containing muscle adherens junctions and contributes to the mechanosensory functions of touch neurons. (348 aa)
dys-1Dystrophin-1; Plays a role in cholinergic transmission and as a functional partner of dystrobrevin (dyb-1), necessary for muscle maintenance. Required for neuronal positioning. (3674 aa)
lim-9LIM domain family. (793 aa)
lim-8LIM domain family. (1099 aa)
unc-45TPR_REGION domain-containing protein. (961 aa)
uig-1PH domain-containing protein. (972 aa)
zyx-1Zyxin; Functions as both a mechanical stabilizer (via LIM domains) of focal adhesions and as a sensor component for muscle cell damage (via N-terminus). Regulates, stabilizes and maintains posterior lateral mechanosensory (PLM) synaptic branch extension and new synapse formation and growth during larval development. (647 aa)
pos-1Cytoplasmic zinc-finger protein. (264 aa)
deb-1Vinculin; Involved in cell adhesion. May be involved in the attachment of the actin-based microfilaments to the plasma membrane. Involved in ovulation. (1090 aa)
lin-11Protein lin-11; Probable transcription factor which is required for asymmetric division of vulval blast cells. Involved in olfactory plasticity probably by regulating the expression of transcription factor mbr-1 in RIF neurons. Plays a role in the chemorepulsive response toward ascaroside pheromones mediated by the ADL sensory neurons, probably by regulating E-box motif 5'-CANNTG-3' containing target genes in the ADL neurons. Plays a role in the differentiation of the ADL sensory neurons. (405 aa)
tln-1Talin. (2553 aa)
pola-1DNA polymerase. (1456 aa)
Y37B11A.2DNA polymerase. (1303 aa)
Y23H5B.6RNA helicase. (732 aa)
unc-95LIM domain-containing protein unc-95; Required for the assembly and integrity of muscle dense bodies, which establish the adhesion sites of the muscle cells to the extracellular matrix. Decreased localization of unc-95 to dense bodies and their subsequent dissociation plays an important role in ecdysis during molting. Involved in the organization of the muscle sarcomeric structure and thereby required for locomotion. (350 aa)
atn-1AcTiniN. (920 aa)
act-5ACTin. (375 aa)
pat-6Paralyzed arrest at two-fold protein 6; Involved in the regulation of cell adhesion and cytoskeleton organization. Component of an integrin containing attachment complex, which is required for muscle development and maintenance. During embryonic development, required to recruit cpna-1, unc-89 and myofilaments to newly forming integrin attachments composed of integrins pat-2/pat-3, pat-4 and unc-112. Also required to reposition the integrin-based attachments so that they form the highly ordered array of dense body and M-line attachments that are characteristic of mature muscle cells. Du [...] (375 aa)
alp-1ALP/Enigma encoding. (1424 aa)
hum-6Unconventional myosin heavy chain 6; Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments (By similarity). (2098 aa)
mlp-1LIM zinc-binding domain-containing protein. (113 aa)
T03G6.3Uncharacterized protein. (465 aa)
mei-1Meiotic spindle formation protein mei-1; Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays. Required specifically for meiotic spindle formation in the female germline; the presence of this protein is inimical to the formation of mitotic spindles. In body wall muscles, regulates organization of myosin thick filaments. (475 aa)
spi-1Serine protease inhibitor 1 protein. (100 aa)
sti-1Stress-induced-phosphoprotein 1; Plays a role in gonad development. Up-regulates longevity and thermotolerance. Binds daf-21/hsp90 and inhibits its ATPase activity. (320 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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