(35 nodes) (2013) The C. elegans gene pan-1 encodes novel transmembrane and cytoplasmic leucine-rich repeat proteins and promotes molting and the larva to adult transition. network (Caenorhabditis elegans)

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Your Input:
	hbl-1	Hunchback-like protein; Required for the late stages of development. Plays a role in the developmental timing of postembryonic hypodermal seam cell fusion events and adult alae production. (982 aa)
	B0511.6	RNA helicase. (544 aa)
	lim-7	LIM domain family. (452 aa)
	mlt-10	Uncharacterized protein. (690 aa)
	C16A3.4	C2H2-type domain-containing protein. (375 aa)
	C23G10.8	DUF1768 domain-containing protein. (937 aa)
	ajm-1	Apical junction molecule; Controls adherens junction integrity. Required for the correct rate and completion of elongation of the embryos. (1905 aa)
	ttx-3	LIM/homeobox protein ttx-3; Required for specification of the AIA and AIY interneurons and the NSM neurons. Positively regulates the expression of a number of genes including ceh-23, kal-1, hen-1, ser-2, unc-17 and sra-11 in AIY interneurons and cat-4, flp-4, bas-1, ptps-1 and mgl-1 in NSM neurons. Also acts in an autoregulatory feedback loop to maintain its own expression. Plays a role in the thermotactic response, olfactory imprinting, regulation of longevity, control of dauer formation and axon outgrowth and pathfinding. Not required for normal chemosensory behavior. (409 aa)
	let-4	Leucine-rich repeat-containing protein let-4; Required for apical extracellular matrix organization and epithelial junction maintenance. (773 aa)
	sym-1	SYM-1 protein. (680 aa)
	nhr-6	Nuclear hormone receptor family member nhr-6; Transcriptional activator that induces gene expression by binding to the NGFI-B response element (NBRE) 5'-AAAGGTCA-3'. Required for proper morphogenesis of the spermatheca and the spermatheca-uterine valve formation. Promotes cell proliferation and differentiation of the spermatheca precursor cells during spermatheca development in larval stage L4. Might play a role in promoting G1/S phase progression in the spermatheca precursor cell lineage. Also required for the differentiation of the spermatheca-uterine junction core (sujc) cells which [...] (619 aa)
	glp-1	Protein glp-1; Involved in the specification of the cell fates of the blastomeres, ABa and APa. Proper signaling by glp-1 induces ABa descendants to produce anterior pharyngeal cells, and APa descendants to adopt a different fate. Contributes to the establishment of the dorsal-ventral axis in early embryos. Regulates germ cell mitotic proliferation probably by regulating MAP kinase phosphatase lip-1 expression. Plays a negative role in lifespan. (1295 aa)
	lin-28	Protein lin-28; Heterochronic protein which controls the choice of stage specific cell fates. Regulates the timing of the second larval stage events (L2 events) in the hypodermis. May negatively regulate the larval to adult transition via the suppression of the microRNA (miRNA) let-7 during L3. Plays a role in the control of seam cell number and vulval development. Belongs to the lin-28 family. (227 aa)
	rrf-3	RNA-dependent RNA polymerase Family. (1765 aa)
	unc-54	Myosin-4; Required for muscle contraction. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1963 aa)
	rrf-1	RNA-dependent RNA polymerase Family. (1601 aa)
	H06I04.3	Putative rRNA methyltransferase; Probable methyltransferase involved in the maturation of rRNA and in the biogenesis of ribosomal subunits. (833 aa)
	egg-6	Leucine-rich repeat-containing protein egg-6; Required for apical extracellular matrix organization and epithelial junction maintenance. (961 aa)
	mtl-1	Metallothionein-1; This protein binds cations of several transition elements. (75 aa)
	pan-1	P-granule-associated novel protein 1; Regulates diverse developmental processes including larval molting and gonad maturation. (594 aa)
	ttr-32	TransThyretin-Related family domain. (139 aa)
	rol-6	Cuticle collagen rol-6; Nematode cuticles are composed largely of collagen-like proteins. The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment. Involved in body morphogenesis. (348 aa)
	dma-1	LRRCT domain-containing protein. (603 aa)
	eri-1	3'-5' exonuclease eri-1; RNA exonuclease that acts as a negative regulator of RNA interference (RNAi). Probably acts by degrading the 3'-overhangs of short interfering RNAs (siRNAs). Its tissue specificity may help explain the inefficiency of neuronal RNAi. (582 aa)
	dpy-10	Cuticle collagen dpy-10; Nematode cuticles are composed largely of collagen-like proteins. The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment. (356 aa)
	glh-1	ATP-dependent RNA helicase glh-1; Probable ATP-binding RNA helicase. May act redundantly with the P-granule component glh-4 to regulate the formation of the granular structure of P-granules in embryos. May play a role in transgenerational epigenetic inheritance. May protect somatic cells from excessive apoptosis during normal development. Belongs to the DEAD box helicase family. DDX4/VASA subfamily. (763 aa)
	vab-9	Cell junction protein VAB-9. (211 aa)
	lin-29	Transcription factor. (459 aa)
	unc-95	LIM domain-containing protein unc-95; Required for the assembly and integrity of muscle dense bodies, which establish the adhesion sites of the muscle cells to the extracellular matrix. Decreased localization of unc-95 to dense bodies and their subsequent dissociation plays an important role in ecdysis during molting. Involved in the organization of the muscle sarcomeric structure and thereby required for locomotion. (350 aa)
	Y23H5B.6	RNA helicase. (732 aa)
	pola-1	DNA polymerase. (1456 aa)
	lag-2	Protein lag-2; Putative intercellular signal for lin-12 and GLP-1 receptors. Functions in uterine cells to promote basement membrane mobility during tissue remodeling. (402 aa)
	glp-4	Valine--tRNA ligase. (1050 aa)
	ZC395.4	Uncharacterized protein. (169 aa)
	her-1	Protein her-1; Dictates male development. Probably plays a direct role in cell signaling during C.elegans sex determination. Inhibits the function of tra-2a. (175 aa)

Your Current Organism:

Caenorhabditis elegans

NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
B0511.6	C16A3.4	B0511.6.1	C16A3.4.2	RNA helicase.	C2H2-type domain-containing protein.	0.656
B0511.6	H06I04.3	B0511.6.1	H06I04.3a.1	RNA helicase.	Putative rRNA methyltransferase; Probable methyltransferase involved in the maturation of rRNA and in the biogenesis of ribosomal subunits.	0.991
B0511.6	Y23H5B.6	B0511.6.1	Y23H5B.6a.1	RNA helicase.	RNA helicase.	0.990
B0511.6	glh-1	B0511.6.1	T21G5.3.1	RNA helicase.	ATP-dependent RNA helicase glh-1; Probable ATP-binding RNA helicase. May act redundantly with the P-granule component glh-4 to regulate the formation of the granular structure of P-granules in embryos. May play a role in transgenerational epigenetic inheritance. May protect somatic cells from excessive apoptosis during normal development. Belongs to the DEAD box helicase family. DDX4/VASA subfamily.	0.532
B0511.6	pan-1	B0511.6.1	M88.6b.1	RNA helicase.	P-granule-associated novel protein 1; Regulates diverse developmental processes including larval molting and gonad maturation.	0.424
B0511.6	rrf-1	B0511.6.1	F26A3.8a.1	RNA helicase.	RNA-dependent RNA polymerase Family.	0.753
B0511.6	rrf-3	B0511.6.1	F10B5.7.1	RNA helicase.	RNA-dependent RNA polymerase Family.	0.434
C16A3.4	B0511.6	C16A3.4.2	B0511.6.1	C2H2-type domain-containing protein.	RNA helicase.	0.656
C16A3.4	C23G10.8	C16A3.4.2	C23G10.8.1	C2H2-type domain-containing protein.	DUF1768 domain-containing protein.	0.707
C16A3.4	H06I04.3	C16A3.4.2	H06I04.3a.1	C2H2-type domain-containing protein.	Putative rRNA methyltransferase; Probable methyltransferase involved in the maturation of rRNA and in the biogenesis of ribosomal subunits.	0.832
C16A3.4	ZC395.4	C16A3.4.2	ZC395.4.1	C2H2-type domain-containing protein.	Uncharacterized protein.	0.809
C16A3.4	pan-1	C16A3.4.2	M88.6b.1	C2H2-type domain-containing protein.	P-granule-associated novel protein 1; Regulates diverse developmental processes including larval molting and gonad maturation.	0.517
C16A3.4	ttr-32	C16A3.4.2	R13A5.3.1	C2H2-type domain-containing protein.	TransThyretin-Related family domain.	0.807
C23G10.8	C16A3.4	C23G10.8.1	C16A3.4.2	DUF1768 domain-containing protein.	C2H2-type domain-containing protein.	0.707
C23G10.8	H06I04.3	C23G10.8.1	H06I04.3a.1	DUF1768 domain-containing protein.	Putative rRNA methyltransferase; Probable methyltransferase involved in the maturation of rRNA and in the biogenesis of ribosomal subunits.	0.820
C23G10.8	ZC395.4	C23G10.8.1	ZC395.4.1	DUF1768 domain-containing protein.	Uncharacterized protein.	0.850
C23G10.8	pan-1	C23G10.8.1	M88.6b.1	DUF1768 domain-containing protein.	P-granule-associated novel protein 1; Regulates diverse developmental processes including larval molting and gonad maturation.	0.589
C23G10.8	pola-1	C23G10.8.1	Y47D3A.29b.1	DUF1768 domain-containing protein.	DNA polymerase.	0.596
C23G10.8	ttr-32	C23G10.8.1	R13A5.3.1	DUF1768 domain-containing protein.	TransThyretin-Related family domain.	0.815
H06I04.3	B0511.6	H06I04.3a.1	B0511.6.1	Putative rRNA methyltransferase; Probable methyltransferase involved in the maturation of rRNA and in the biogenesis of ribosomal subunits.	RNA helicase.	0.991