STRINGSTRING
his-46 his-46 his-14 his-14 his-10 his-10 his-26 his-26 smg-9 smg-9 xrn-1 xrn-1 act-5 act-5 his-67 his-67 his-1 his-1 pnn-1 pnn-1 his-28 his-28 his-18 his-18 smg-8 smg-8 his-38 his-38 his-60 his-60 his-56 his-56 his-5 his-5 his-64 his-64 his-31 his-31 his-50 his-50 his-37 his-37
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
his-46Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
his-14Histone H4. (103 aa)
his-10Histone H4. (103 aa)
his-26Histone H4. (103 aa)
smg-9Protein smg-9; Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Probable component of kinase complex containing smg-1 and recruited to stalled ribosomes. Belongs to the SMG9 family. (385 aa)
xrn-15'-3' exoribonuclease 1. (1591 aa)
act-5ACTin. (375 aa)
his-67Histone H4. (103 aa)
his-1Histone H4. (103 aa)
pnn-1Pinin_SDK_memA domain-containing protein. (359 aa)
his-28Histone H4. (103 aa)
his-18Histone H4. (103 aa)
smg-8Protein smg-8; Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Probable component of kinase complex containing smg-1 and recruited to stalled ribosomes. Belongs to the SMG8 family. (873 aa)
his-38Histone H4. (103 aa)
his-60Histone H4. (103 aa)
his-56Histone H4. (103 aa)
his-5Histone H4. (103 aa)
his-64Histone H4. (103 aa)
his-31Histone H4. (103 aa)
his-50Histone H4. (103 aa)
his-37Histone H4. (103 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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