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cyp-13A8 cyp-13A8 acdh-10 acdh-10 mev-1 mev-1 aldo-1 aldo-1 acs-15 acs-15 B0303.3 B0303.3 sams-4 sams-4 atp-5 atp-5 acdh-2 acdh-2 acdh-13 acdh-13 atp-2 atp-2 acdh-5 acdh-5 rpt-1 rpt-1 C53D5.5 C53D5.5 acdh-1 acdh-1 acdh-12 acdh-12 prdx-2 prdx-2 ldh-1 ldh-1 acdh-9 acdh-9 acs-2 acs-2 lbp-1 lbp-1 alh-1 alh-1 tsfm-1 tsfm-1 nsy-1 nsy-1 acdh-8 acdh-8 acdh-3 acdh-3 gst-4 gst-4 gpd-2 gpd-2 ctb-1 ctb-1 nhr-49 nhr-49 pdhk-2 pdhk-2 gpi-1 gpi-1 rps-6 rps-6 ctl-1 ctl-1 ctl-3 ctl-3 lbp-5 lbp-5 acdh-7 acdh-7 act-5 act-5 acdh-4 acdh-4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
cyp-13A8Putative cytochrome P450 CYP13A8; Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. (509 aa)
acdh-10Probable medium-chain specific acyl-CoA dehydrogenase 10, mitochondrial; This enzyme is specific for acyl chain lengths of 4 to 16. Belongs to the acyl-CoA dehydrogenase family. (417 aa)
mev-1Succinate dehydrogenase cytochrome b560 subunit, mitochondrial; Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q) (By similarity). Mediates resistance to enteropathogenic E.coli infection. Belongs to the cytochrome b560 family. (182 aa)
aldo-1Fructose-bisphosphate aldolase 1. (365 aa)
acs-15Fatty Acid CoA Synthetase family. (703 aa)
B0303.3Uncharacterized protein B0303.3; Belongs to the thiolase-like superfamily. Thiolase family. (448 aa)
sams-4Probable S-adenosylmethionine synthase 4; Catalyzes the formation of S-adenosylmethionine from methionine and ATP. The reaction comprises two steps that are both catalyzed by the same enzyme: formation of S-adenosylmethionine (AdoMet) and triphosphate, and subsequent hydrolysis of the triphosphate; Belongs to the AdoMet synthase family. (404 aa)
atp-5ATP synthase subunit. (191 aa)
acdh-2Acyl CoA DeHydrogenase. (386 aa)
acdh-13Acyl CoA DeHydrogenase. (617 aa)
atp-2ATP synthase subunit beta, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the c [...] (538 aa)
acdh-5Acyl CoA DeHydrogenase. (442 aa)
rpt-126S proteasome regulatory subunit 7; The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex (By similarity). (435 aa)
C53D5.5Uncharacterized protein. (642 aa)
acdh-1Acyl CoA DeHydrogenase. (427 aa)
acdh-12Acyl CoA DeHydrogenase. (613 aa)
prdx-2Thioredoxin domain-containing protein. (201 aa)
ldh-1L-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. LDH family. (336 aa)
acdh-9Acyl CoA DeHydrogenase. (409 aa)
acs-2Fatty Acid CoA Synthetase family. (618 aa)
lbp-1Fatty acid-binding protein homolog 1; May play a role in sequestering potentially toxic fatty acids and their peroxidation products, or it may be involved in the maintenance of the impermeable lipid layer of the eggshell. Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (159 aa)
alh-1Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family. (510 aa)
tsfm-1Elongation factor Ts, mitochondrial; Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome. Belongs to the EF-Ts family. (316 aa)
nsy-1Mitogen-activated protein kinase kinase kinase nsy-1; Serine/threonine-protein kinase which, by phosphorylating and activating sek-1, plays an important role in the activation of the p38 pathway also composed of the downstream effectors sek-1 and pmk-1. Downstream of CaMKII unc-43 and adapter protein tir-1, plays a role in determining asymmetric cell fates in olfactory AWC neurons during neuronal development. Activation results in the repression of odorant receptor str-2 expression in one of the 2 AWC neurons. Involved in resistance to pathogenic Gram-positive and Gram-negative bacteri [...] (1498 aa)
acdh-8Acyl CoA DeHydrogenase. (412 aa)
acdh-3Acyl CoA DeHydrogenase. (419 aa)
gst-4Glutathione S-transferase 4; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles (By similarity). May play a role in the detoxification of reactive oxygen species produced during pathogenic bacterial infection. (207 aa)
gpd-2Glyceraldehyde-3-phosphate dehydrogenase 2. (341 aa)
ctb-1Cytochrome b; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c (By similarity). Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis. (370 aa)
nhr-49Nuclear hormone receptor family member nhr-49; Orphan nuclear receptor. Regulates expression of lipid desaturase, fat-7 ; Belongs to the nuclear hormone receptor family. (501 aa)
pdhk-2Probable [pyruvate dehydrogenase (acetyl-transferring)] kinase, mitochondrial; Inhibits the mitochondrial pyruvate dehydrogenase complex by phosphorylation of the E1 alpha subunit, thus contributing to the regulation of glucose metabolism. (401 aa)
gpi-1Glucose-6-phosphate isomerase; Belongs to the GPI family. (586 aa)
rps-640S ribosomal protein S6; May play an important role in controlling cell growth and proliferation through the selective translation of particular classes of mRNA (By similarity). Negatively regulates lifespan ; Belongs to the eukaryotic ribosomal protein eS6 family. (246 aa)
ctl-1Catalase-2; Catalase involved in the oxidative stress response serving to protect cells from toxicity (Probable). For instance plays a role in defending against oxidative damage induced by excessive copper stress. Not required for maintaining normal lifespan. (497 aa)
ctl-3Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. (512 aa)
lbp-5Fatty acid-binding protein homolog 5; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (136 aa)
acdh-7Acyl CoA DeHydrogenase. (412 aa)
act-5ACTin. (375 aa)
acdh-4Acyl CoA DeHydrogenase. (385 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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