STRINGSTRING
his-37 his-37 hda-11 hda-11 dop-6 dop-6 his-56 his-56 his-46 his-46 his-60 his-60 his-38 his-38 his-18 his-18 his-28 his-28 hda-3 hda-3 dop-5 dop-5 lsd-1 lsd-1 his-1 his-1 his-14 his-14 his-10 his-10 his-26 his-26 hda-10 hda-10 slo-1 slo-1 snn-1 snn-1 cdk-5 cdk-5 his-67 his-67 his-5 his-5 hda-5 hda-5 his-64 his-64 his-31 his-31 dop-1 dop-1 his-50 his-50
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
his-37Histone H4. (103 aa)
hda-11Hist_deacetyl domain-containing protein. (334 aa)
dop-6G_PROTEIN_RECEP_F1_2 domain-containing protein. (682 aa)
his-56Histone H4. (103 aa)
his-46Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
his-60Histone H4. (103 aa)
his-38Histone H4. (103 aa)
his-18Histone H4. (103 aa)
his-28Histone H4. (103 aa)
hda-3Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (465 aa)
dop-5G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (763 aa)
lsd-1Probable lysine-specific histone demethylase 1; Probable histone demethylase that specifically demethylates 'Lys-4' of histone H3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Demethylates both mono- and di-methylated 'Lys-4' of histone H3. (737 aa)
his-1Histone H4. (103 aa)
his-14Histone H4. (103 aa)
his-10Histone H4. (103 aa)
his-26Histone H4. (103 aa)
hda-10Hist_deacetyl domain-containing protein. (517 aa)
slo-1Calcium-activated potassium channel slo-1; Potassium channel activated by both membrane depolarization or increase in cytosolic Ca(2+) that mediates export of K(+). Its activation dampens the excitatory events that elevate the cytosolic Ca(2+) concentration and/or depolarize the cell membrane. It therefore contributes to repolarization of the membrane potential. Essential for the regulation of neurotransmitter release at synapses. (1160 aa)
snn-1ATP-grasp domain-containing protein. (474 aa)
cdk-5Cyclin-dependent-like kinase 5; Proline-directed serine/threonine-protein kinase which, in several motor neurons, promotes the polarized trafficking of synaptic vesicles and dense-core vesicles (DCV). In the ventral nerve cord, phosphorylates lin-10 and thereby prevents lin-10-mediated anterograde trafficking of the glutamate receptor glr-1. Involved in the inhibition of glr-1 trafficking in hypoxic conditions. In DA motor neurons but not in DB motor neurons, regulates axonal transport of synaptic vesicle precursors by inhibiting dynein-mediated retrograde transport. Regulates the traf [...] (292 aa)
his-67Histone H4. (103 aa)
his-5Histone H4. (103 aa)
hda-5Hist_deacetyl domain-containing protein. (508 aa)
his-64Histone H4. (103 aa)
his-31Histone H4. (103 aa)
dop-1G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (460 aa)
his-50Histone H4. (103 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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