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| | cey-4 | CSP domain-containing protein. (294 aa) |
| | pap-1 | Poly(A) polymerase; Polymerase that creates the 3'-poly(A) tail of mRNA's. (655 aa) |
| | Y23H5B.6 | RNA helicase. (732 aa) |
| | car-1 | Cytokinesis, Apoptosis, RNA-associated. (340 aa) |
| | fog-2 | F-box domain-containing protein. (327 aa) |
| | mex-1 | Muscle EXcess. (494 aa) |
| | air-2 | Aurora/IPL1-related protein kinase 2; Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of chromosome segregation and cytokinesis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation. Required for histone H3 phosphorylation during segregation of homologous chromosomes in meiosis and mitosis. Required for histone H3 'Ser- 10' phosphorylation. Phosphorylates tlk-1 at 'Ser-634', which enhances its activity. Phosphorylates zen-4 at 'Ser- 680'. Required f [...] (305 aa) |
| | ife-3 | Eukaryotic translation initiation factor 4E-3; Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. All 5 eIF4E proteins bind monomethyl cap structures. Only ife-1, ife-2 and ife-5 bind trimethyl cap structures which result from trans-splicing. Translation of trimethyl cap structure mRNAs may be regulated by intracellular redox state; disulfide bonds change the width and depth of the cap-binding cavity determining selectivit [...] (251 aa) |
| | cpb-3 | Cytoplasmic polyadenylation element-binding protein 3; Cytoplasmic polyadenylation element binding protein that binds to and regulates the translation of specific mRNAs (By similarity). May not be required for oogenesis. (745 aa) |
| | B0511.6 | RNA helicase. (544 aa) |
| | fog-3 | Anti_prolifrtn domain-containing protein. (263 aa) |
| | fce-1 | CAAX prenyl protease 1 homolog; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (442 aa) |
| | cgh-1 | ATP-dependent RNA helicase cgh-1; Probable RNA helicase required for oocyte and sperm function. Also required to prevent the physiological germline apoptosis mechanism killing essentially all developing oocytes. Belongs to the DEAD box helicase family. DDX6/DHH1 subfamily. (430 aa) |
| | zyg-11 | Early embryogenesis protein zyg-11; Acts as target recruitment subunit in the E3 ubiquitin ligase complex zyg-11-cul-2-elc-1. Required for metaphase to anaphase transition and M phase exit at meiosis II. Regulates polarity establishment. (799 aa) |
| | pcm-1 | Protein-L-isoaspartate O-methyltransferase; Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins. This enzyme does not act on D-aspartyl residues. (225 aa) |
| | lin-41 | Protein lin-41; Heterochronic protein which acts downstream of let-7 in temporal patterning. Plays a role in the developmental timing of postembryonic hypodermal seam cell division and fusion events and adult alae production. Represses lin-29 during late larval stages, which prevents terminal differentiation of hypodermal seam cells and promotes their division. Involved in post-transcriptional gene regulation, uses two independent pathways. Has direct and specific RNA-binding activity and, depending on the location (5'UTR or 3'UTR) of the target site, triggers either mRNA decay or repr [...] (1147 aa) |
| | rnf-5 | E3 ubiquitin ligase rnf-5; E3 ubiquitin ligase that plays a role in the maintenance of muscle cell boundaries and muscle dense bodies, which establish the adhesion sites of the muscle cells to the extracellular matrix. Ubiquitinates the LIM domain protein unc-95, thereby regulating its dislocalization from muscle dense bodies and weakening the link between the muscle cells and the hypodermis. Regulation of unc-95 dissociation from muscle dense bodies by ubiquitination plays an important role in ecdysis during molting. Plays a role in the cessation of distal tip cell migration at the en [...] (235 aa) |
| | spe-9 | Sperm transmembrane protein 9; Required for fertilization. May be required for cell adhesion and/or function as a signaling molecule. (661 aa) |
| | C27B7.2 | Uncharacterized protein. (196 aa) |
| | cpb-2 | Cytoplasmic polyadenylation element-binding protein 2; Cytoplasmic polyadenylation element binding protein that binds to and regulates the translation of specific mRNAs (By similarity). Not required for oogenesis. (570 aa) |
| | cpb-1 | Cytoplasmic polyadenylation element-binding protein 1; Cytoplasmic polyadenylation element binding protein that binds to and regulates the translation of specific mRNAs. Essential for progression through meiosis. Involved in spermatogenesis. (560 aa) |
| | C46A5.4 | Uncharacterized protein. (1537 aa) |
| | hsp-90 | Heat shock protein 90; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co- chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. By stabilizing the receptor-type guanylate cyclase daf-11 or another sig [...] (702 aa) |
| | wdr-23 | DDB1- and CUL4-associated factor 11 homolog; Involved in regulation of lifespan. Required for dopaminergic CEP neuron degeneration in response to Mn(2+). (571 aa) |
| | DH11.5 | C2 domain-containing protein. (825 aa) |
| | glp-1 | Protein glp-1; Involved in the specification of the cell fates of the blastomeres, ABa and APa. Proper signaling by glp-1 induces ABa descendants to produce anterior pharyngeal cells, and APa descendants to adopt a different fate. Contributes to the establishment of the dorsal-ventral axis in early embryos. Regulates germ cell mitotic proliferation probably by regulating MAP kinase phosphatase lip-1 expression. Plays a negative role in lifespan. (1295 aa) |
| | unc-54 | Myosin-4; Required for muscle contraction. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1963 aa) |
| | F15E6.3 | RRM-type RNA binding protein. (118 aa) |
| | cdc-25.2 | M-phase inducer phosphatase cdc-25.2; Required for intestinal cell division following the 16E cell stage of embryogenesis. Regulates intestinal cell divisions and binucleations probably by modulating the activity of the cell cycle regulator wee-1.3 and by activating the cdk-1/cyb-1 complex. Belongs to the MPI phosphatase family. (480 aa) |
| | fbf-2 | Fem-3 mRNA-binding factor 2; Involved in the control of stem cells and sex determination in the C.elegans hermaphrodite germline. May also play a role in the hermaphrodite germline proliferation and oogenesis. By binding to the 3'-UTR, represses phosphatase lip-1 expression in the distal part of the germline mitotic zone. Binds specifically to the regulatory region of fem-3 3'-UTR and mediates the sperm/oocyte switch. Negatively regulates gld-3 expression possibly by directly binding to two sites within the gld-3 isoform b 3'-UTR. Suppresses germline tumor formation by preventing the d [...] (632 aa) |
| | rom-1 | Rhomboid-related protein 1; Serine protease which activates lin-3 isoform a in the proximal vulva precursor cells (VPC) during vulva development to transmit the inductive anchor cell signal to the distal VPCs. (356 aa) |
| | fem-1 | Sex-determining protein fem-1; Sex-determining protein; essential for the adoption of the male sexual fate in all tissues. Substrate recognition subunit of the cullin-RING-based CBC(fem-1) (Cul2-ElonginB-ElonginC) E3 ubiquitin- protein ligase complex which mediates in association with cofactors fem-2 and fem-3 the ubiquitination and subsequent proteasomal degradation of tra-1. (656 aa) |
| | mom-2 | Protein mom-2; Ligand for members of the frizzled family of seven transmembrane receptors. Required in embryonic development for endoderm specification and the correct positioning and orientation of the mitotic spindles and division planes in blastomere cells. Involved in cleavage axis determination. Binds to receptor tyrosine kinase cam-1. Together with wnt ligand lin-44, plays a role in controlling vulva precursor cell P7.p lineage orientation during vulva development, probably by acting as a ligand for tyrosine kinase receptor lin-18. May act redundantly with other Wnt ligands such [...] (362 aa) |
| | mpk-1 | Mitogen-activated protein kinase mpk-1; Function in let-60 Ras signaling pathway; acts downstream of lin-45 raf kinase, but before the lin-1 gene product in controlling vulval cell differentiation. Plays a negative role in proximal germline proliferation in the mitotic zone. Required for progression of developing oocytes through the pachytene stage. In oocytes, inhibits the activity of the chloride channel clh-3, likely by activating gck-3. Plays a role in response to M.nematophilum-mediated bacterial infection by promoting tail swelling and preventing constipation. Involved in fluid h [...] (444 aa) |
| | F43G6.5 | Poly(A) polymerase; Polymerase that creates the 3'-poly(A) tail of mRNA's. (554 aa) |
| | sdz-18 | BTB domain-containing protein. (277 aa) |
| | mbk-2 | Dual specificity tyrosine-phosphorylation-regulated kinase mbk-2; Required for oocyte-to-zygote transition in which it phosphorylates oocyte proteins, including mei-1, oma-1, oma-2, mex-5, and mex-6, modifying their activity and/or stability following meiosis. Functions in both spindle positioning and in the posterior localization of cytoplasmic determinants, including pie-1, pos-1, and pgl-1, in early embryos. Involved in the asymmetric distribution of plk-1 at the 2-cell embryonic stage. (817 aa) |
| | pos-1 | Cytoplasmic zinc-finger protein. (264 aa) |
| | mex-3 | Muscle EXcess. (443 aa) |
| | puf-5 | Pumilio domain-containing protein 5; RNA-binding protein that binds to the consensus sequence 5'- CUCUGUAUCUUGU-3' in mRNA 3'-UTRs and modulates mRNA expression and stability. Functions redundantly with puf-6 and puf-7 in oocyte formation and organization, early embryonic cell divisions, and repression of expression of glp-1 and other maternal mRNAs in late oogenesis. (553 aa) |
| | ifet-1 | Translational repressor ifet-1; Involved in translational repression of multiple mRNAs in the distal gonad. Recruited to the 3' untranslated region (UTR) of zif-1 by oma-1 and is required for translational repression of zif-1. May also be involved in translational repression of mei-1 through recruitment to the mei-1 3' UTR by oma-1. Required for oogenesis but not spermatogenesis, for P granule formation and for the localization of car-1 and cgh-1 to P granules. Required for normal spindle orientation in early embryos. (761 aa) |
| | let-711 | Not1 domain-containing protein. (2641 aa) |
| | hrp-2 | HnRNP A1 homolog. (611 aa) |
| | zif-1 | Zinc finger-interacting factor 1; Probable substrate recognition component of a CBC (Cul2- ElonginB-ElonginC) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Ensures germline precursor cell asymmetry by targeting germline proteins for destruction if expressed in non-germline cells. This process also requires elc-1, cul-2, rbx-1 and ubc-2. (489 aa) |
| | fbf-1 | Fem-3 mRNA-binding factor 1; Involved in the control of stem cells and sex determination in the C.elegans hermaphrodite germline. May also play a role in the hermaphrodite germline proliferation and oogenesis. Binds specifically to the regulatory region of fem-3 3'-UTR and mediates the sperm/oocyte switch. Negatively regulates gld-3 expression, possibly by directly binding to two sites within the 3'-UTR of gld-3 isoform b. In association with the cye-1/cdk-2 complex, negatively regulates gld-1 expression in the distal germline cells of the mitotic zone. By binding to the 3'-UTR, repres [...] (614 aa) |
| | sacy-1 | Suppressor of ACY-4 sterility; Belongs to the DEAD box helicase family. (630 aa) |
| | cyb-2.2 | Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (339 aa) |
| | bli-4 | Endoprotease bli-4; Serine endoprotease which cleaves proproteins at paired basic amino acids (Probable). Involved in cuticle biosynthesis probably by cleaving pro-collagen into its mature form. Acts in ASEL sensory neurons to regulate high salt chemotaxis responses probably by cleaving insulin-like protein ins-6 into its mature and active form. Essential for embryonic and larval development. isoform a, isoform e, isoform f, isoform g and isoform h are involved in cuticle biosynthesis but are dispensable for larval development. (942 aa) |
| | pxn-2 | PeroXidasiN (Drosophila peroxidase) homolog. (1328 aa) |
| | vit-1 | Vitellogenin-1; Precursor of the egg-yolk proteins that are sources of nutrients during embryonic development. (1616 aa) |
| | ifg-1 | MIF4G domain-containing protein. (1156 aa) |
| | unc-119 | Protein unc-119; Myristoyl-binding protein that acts as a cargo adapter: specifically binds the myristoyl moiety of a subset of N-terminally myristoylated proteins and is required for their localization. Plays a key role in ciliary membrane localization of proteins. Required for the establishment or function of the nervous system. (244 aa) |
| | edc-3 | DFDF domain-containing protein. (566 aa) |
| | gsa-1 | G protein, Subunit Alpha. (378 aa) |
| | pqn-59 | Prion-like-(Q/N-rich)-domain-bearing protein. (712 aa) |
| | taf-4 | TAFH domain-containing protein. (523 aa) |
| | acy-4 | Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1013 aa) |
| | mei-1 | Meiotic spindle formation protein mei-1; Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays. Required specifically for meiotic spindle formation in the female germline; the presence of this protein is inimical to the formation of mitotic spindles. In body wall muscles, regulates organization of myosin thick filaments. (475 aa) |
| | cdk-1 | Cyclin-dependent kinase 1; Plays a key role in the control of the eukaryotic cell cycle. It is required in higher cells for entry into S-phase and mitosis. p34 is a component of the kinase complex that phosphorylates the repetitive C-terminus of RNA polymerase II (By similarity). (332 aa) |
| | T06D8.10 | Uncharacterized protein. (1490 aa) |
| | gld-3 | Defective in germ line development protein 3; Required maternally for germline survival and embryogenesis. Forms a complex with gls-1 which promotes the oogenic cell fate by freeing the translational repressor fbf to repress sperm promoting factors. Promotes maturation of primary spermatocytes to mature sperm. Required during hermaphrodite development to promote sperm fate, which is critical for determining the normal number of sperm. Promotion of sperm fate is at the expense of oogenesis, possibly through the negative regulation of fbf. Required during male development for the continu [...] (969 aa) |
| | rme-2 | Receptor Mediated Endocytosis. (925 aa) |
| | T15H9.6 | Poly(A) polymerase; Polymerase that creates the 3'-poly(A) tail of mRNA's. (554 aa) |
| | gld-1 | Female germline-specific tumor suppressor gld-1; RNA-binding protein which recognizes the 5'-UACUCAU-3' RNA consensus sequence. Binds sequences in both the 5'coding and the 3'-UTR region of rme-2 mRNA. Binds sequences in the 3'-UTR region of cye-1 mRNA. Binds to cyb-2.1, cyb-2.2 and cyb-3 mRNA. Binds sequences in the 3'-UTR region of tra-2 mRNA. Germ line-specific tumor suppressor essential for oogenesis. Controls the spatial pattern of translation of multiple oogenesis specific mRNAs (e.g. yolk receptor rme-2) by repression of translation during early meiotic prophase (leptotene to pa [...] (463 aa) |
| | pqn-70 | Prion-like-(Q/N-rich)-domain-bearing protein. (243 aa) |
| | pxn-1 | Peroxidasin homolog; Belongs to the peroxidase family. XPO subfamily. (1285 aa) |
| | kin-1 | cAMP-dependent protein kinase catalytic subunit; Essential for larval development. Controls the rhythmic contraction of enteric muscles probably by regulating G- protein coupled receptor aex-2-mediated calcium influx in GABAergic DVB neurons. Plays a role in the control of oocyte meiotic maturation by gonadal sheath cells. Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily. (579 aa) |
| | gap-2 | Ras GTPase-activating protein gap-2; GTPase-activating protein, which acts as a negative regulator for the member of the Ras family let-60. Probably decreases the signaling activity of Ras by stimulating its intrinsic GTPase activity, thereby lowering the levels of GTP-bound, active Ras. The different isoforms may play a distinct role in specific tissues. (1259 aa) |
| | rnp-1 | RNA-binding protein rnp-1; RNA-binding protein that is required for the germ line to transition from spermatogenesis to oogenesis and allow for normal oocyte development. (305 aa) |
| | cdc-25.3 | M-phase inducer phosphatase cdc-25.3. (316 aa) |
| | unc-13 | Phorbol ester/diacylglycerol-binding protein unc-13; May form part of a signal transduction pathway, transducing the signal from diacylglycerol to effector functions. One such function could be the release of neurotransmitter from neurons. Probably by regulating neuronal transmission downstream of lin-3 and receptor lin-23 and phospholipase plc-3 and upstream of innexin unc-7 and egl-4/PKG in ALA neurons, involved in the decrease in pharyngeal pumping during the quiescent state that precedes each larval molt. (2155 aa) |
| | nos-2 | Nanos-type domain-containing protein; Belongs to the nanos family. (259 aa) |
| | ccr-4 | Endo/exonuclease/phosphatase domain-containing protein. (677 aa) |
| | oma-2 | CCCH-type zinc finger protein oma-2; Zinc-finger RNA-binding protein that binds to 5'-UA[AU]-3' motifs in the 3'-UTR of maternal mRNAs to suppress translation in oocytes and embryos. Acts redundantly with oma-1 to control the temporal expression and distribution of maternal proteins and thereby promote meiotic progression, oocyte maturation, fertilization and embryonic development. Also, together with oma-1, is involved in P-granule distribution during embryonic development. (393 aa) |
| | spn-4 | RRM domain-containing protein. (351 aa) |
| | gld-2 | Poly(A) RNA polymerase gld-2; Cytoplasmic poly(A) RNA polymerase that adds successive AMP monomers to the 3'-end of specific RNAs, forming a poly(A) tail. Acts as a regulator of mitosis/meiosis required for progression through meiotic prophase during oogenesis and spermatogenesis and for promotion of the entry into meiosis from the mitotic cell cycle. May act by regulating and activating gld-1 mRNA activity in germline. (1113 aa) |
| | sqd-1 | Homologous to Drosophila SQD (Squid) protein. (308 aa) |
| | ccf-1 | CCR4-NOT transcription complex subunit 7; Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression; Belongs to the CAF1 family. (310 aa) |
| | fog-1 | RRM domain-containing protein. (619 aa) |
| | wee-1.3 | Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase wee-1.3; Acts as a negative regulator of entry into mitosis (G2 to M transition) by phosphorylation of the CDK1 kinase during oocyte maturation. Required for oocyte maturation, embryonic development, germline proliferation and initiation of meiosis during spermatogenesis. Required for chromosome structure during mitosis and negative regulation of nuclear envelope breakdown. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. WEE1 subfamily. (677 aa) |
| | gcn-1 | TOG domain-containing protein. (2651 aa) |
| | cyb-2.1 | Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (317 aa) |
