STRINGSTRING
abu-1 abu-1 nhr-23 nhr-23 abu-8 abu-8 abu-15 abu-15 abu-6 abu-6 abu-7 abu-7 pqn-13 pqn-13 hsp-3 hsp-3 F32B4.4 F32B4.4 hsp-4 hsp-4 chs-2 chs-2 myrf-1 myrf-1 unc-119 unc-119 cdc-42 cdc-42 abu-9 abu-9 pqn-57 pqn-57 xbp-1 xbp-1 abu-11 abu-11 dpy-10 dpy-10 eat-17 eat-17 rab-6.2 rab-6.2 abu-5 abu-5 abu-14 abu-14
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
abu-1Activated in Blocked Unfolded protein response. (425 aa)
nhr-23Nuclear hormone receptor family member nhr-23; Orphan nuclear receptor; Belongs to the nuclear hormone receptor family. NR1 subfamily. (588 aa)
abu-8Activated in Blocked Unfolded protein response. (445 aa)
abu-15Activated in Blocked Unfolded protein response. (388 aa)
abu-6Activated in Blocked Unfolded protein response. (388 aa)
abu-7Activated in Blocked Unfolded protein response. (438 aa)
pqn-13Prion-like-(Q/N-rich)-domain-bearing protein. (661 aa)
hsp-3Heat shock 70 kDa protein C; Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER. (661 aa)
F32B4.4Pharyngeal muscle protein 2; Involved in pharyngeal muscle development and ensures pharyngeal grinder function during feeding. Plays a role in the defense against the accumulation of ingested live pathogenic bacteria in the intestine. Has a role in the determination of life span. (1073 aa)
hsp-4Endoplasmic reticulum chaperone BiP homolog; Endoplasmic reticulum chaperone that plays a key role in protein folding and quality control in the endoplasmic reticulum lumen (By similarity). Required for ER dynamics during the first embryonic cell divisions. Specifically, controls ER transition into sheet-like structures at the onset of mitosis, possibly by regulating homotypic membrane fusion. Belongs to the heat shock protein 70 family. (657 aa)
chs-2Chitin synthase chs-2; May be involved in chitin synthesis in the pharynx during larval development; Belongs to the chitin synthase family. Class IV subfamily. (1700 aa)
myrf-1Myelin regulatory factor homolog 1, C-terminal; [Myelin regulatory factor homolog 1]: Constitutes a precursor of the transcription factor. Mediates the autocatalytic cleavage that releases the Myelin regulatory factor homolog 1, N-terminal component that specifically activates transcription of genes involved in synaptic rewiring during nervous system maturation. [Myelin regulatory factor homolog 1, N-terminal]: Transcription factor that specifically activates expression of genes involved in synaptic rewiring during nervous system maturation. Specifically required for dorsal D (DD) GABA [...] (931 aa)
unc-119Protein unc-119; Myristoyl-binding protein that acts as a cargo adapter: specifically binds the myristoyl moiety of a subset of N-terminally myristoylated proteins and is required for their localization. Plays a key role in ciliary membrane localization of proteins. Required for the establishment or function of the nervous system. (244 aa)
cdc-42Cell division control protein 42 homolog; Plays an essential role in spindle orientation and organizing cellular and embryonic polarity by controlling the localization and activity of PAR (partitioning-defective) proteins. Required for maintaining the asymmetric cortical localization of the anterior complex proteins par-3 and par-6, the posterior cortical protein par-2, and pkc-3. Involved in hypodermal cell fusion, together with pak-1 and ced-10, leading to embryonic body elongation, which involves dramatic cytoskeletal reorganization. During gonad morphogenesis, plays a role in dista [...] (191 aa)
abu-9Activated in Blocked Unfolded protein response. (378 aa)
pqn-57Activated in Blocked Unfolded protein response; Prion-like-(Q/N-rich)-domain-bearing protein. (378 aa)
xbp-1BZIP domain-containing protein. (335 aa)
abu-11Activated in Blocked Unfolded protein response. (395 aa)
dpy-10Cuticle collagen dpy-10; Nematode cuticles are composed largely of collagen-like proteins. The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment. (356 aa)
eat-17Rab-GAP TBC domain-containing protein. (888 aa)
rab-6.2Ras-related protein Rab-6.2; Protein transport. Probably involved in vesicular traffic (By similarity). (205 aa)
abu-5Activated in Blocked Unfolded protein response. (335 aa)
abu-14Activated in Blocked Unfolded protein response. (373 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
Server load: low (20%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.