STRINGSTRING
dkf-2 dkf-2 act-5 act-5 cdh-1 cdh-1 cdc-42 cdc-42 cdh-7 cdh-7 mlc-7 mlc-7 mlc-6 mlc-6 cdh-9 cdh-9 rgs-7 rgs-7 rgs-8.1 rgs-8.1 nfm-1 nfm-1 egl-10 egl-10 cdh-8 cdh-8 rgs-2 rgs-2 pkc-3 pkc-3 cdh-5 cdh-5 cdh-10 cdh-10 eat-16 eat-16 tiam-1 tiam-1 kin-4 kin-4 rgs-1 rgs-1 cdh-12 cdh-12 rgs-8.2 rgs-8.2 rho-1 rho-1 max-2 max-2 rgs-4 rgs-4 pcn-1 pcn-1 dkf-1 dkf-1 atn-1 atn-1 ZK970.8 ZK970.8 deb-1 deb-1 afd-1 afd-1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
dkf-2Serine/threonine-protein kinase dkf-2; Converts transient diacylglycerol (DAG) signals into prolonged physiological effects, downstream of PKC. Acts in the intestine to regulate both innate immunity by promoting activation of PMK-1 and also stress response and life span by acting as an upstream, negative regulator of the daf-16 transcription factor. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PKD subfamily. (1095 aa)
act-5ACTin. (375 aa)
cdh-1CaDHerin family. (2779 aa)
cdc-42Cell division control protein 42 homolog; Plays an essential role in spindle orientation and organizing cellular and embryonic polarity by controlling the localization and activity of PAR (partitioning-defective) proteins. Required for maintaining the asymmetric cortical localization of the anterior complex proteins par-3 and par-6, the posterior cortical protein par-2, and pkc-3. Involved in hypodermal cell fusion, together with pak-1 and ced-10, leading to embryonic body elongation, which involves dramatic cytoskeletal reorganization. During gonad morphogenesis, plays a role in dista [...] (191 aa)
cdh-7CaDHerin family. (1364 aa)
mlc-7Myosin Light Chain. (153 aa)
mlc-6Myosin Light Chain. (143 aa)
cdh-9CaDHerin family. (623 aa)
rgs-7Regulator of G-protein signaling rgs-7; Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunit egl-30 (G-alpha(q)), thereby driving it into its inactive GDP-bound form. May organize egl-30 into a stable multiprotein signaling complex, and thereby persistently inhibit egl-30 when triggered by calcium or phospholipids. (819 aa)
rgs-8.1RGS domain-containing protein. (229 aa)
nfm-1FERM domain-containing protein. (709 aa)
egl-10Regulator of G-protein signaling egl-10; Involved in egg-laying and locomotion. May regulate G protein goa-1 signaling. (639 aa)
cdh-8CaDHerin family. (1684 aa)
rgs-2Regulator of G-protein signaling rgs-2; Weakly inhibits G protein signaling in nervous system, interacting preferentially with the G(O) subfamily member goa-1. In vitro, it acts as a GTPase activator of goa-1. Rgs-1 and rgs-2 redundantly adjust signaling when worms are fed to allow rapid induction of egg-laying behavior. Modulates chemotaxis responses by regulating negatively the sensitivity to quinine in ASH sensory neurons. (181 aa)
pkc-3Protein kinase C-like 3; Required for the normal progression of embryogenesis and viability of the organism. Plays an indispensable role in establishing embryonic polarity and in recruiting and maintaining par-6 to the periphery, through interaction with par-3. Required for epithelial cell polarity in the distal spermatheca. Phosphorylates serine residues of num-1. Required for the expression of antimicrobial peptide nlp-29 in response in response to fungal infection or physical injury. (597 aa)
cdh-5CaDHerin family. (1449 aa)
cdh-10CaDHerin family. (1775 aa)
eat-16Uncharacterized protein. (473 aa)
tiam-1DH domain-containing protein. (889 aa)
kin-4Protein KINase. (1831 aa)
rgs-1Regulator of G-protein signaling rgs-1; Inhibits G protein signaling in nervous system, interacting preferentially with the G(O) subfamily member goa-1. In vitro, protein acts as a GTPase activator of goa-1. Rgs-1 and rgs-2 redundantly adjust signaling when worms are fed to allow rapid induction of egg-laying behavior. (247 aa)
cdh-12CaDHerin family. (2904 aa)
rgs-8.2Regulator of G protein Signaling. (229 aa)
rho-1Ras-like GTP-binding protein rhoA; Required for ventral migration of epidermal cells during ventral enclosure in the embryo and for cell elongation. Also required for ventral migration of P cells during larval development. Involved in asymmetric spindle positioning during anaphase and establishment of cell polarity during embryo development. In adults, involved in regulation of multiple processes including locomotion, pharyngeal pumping, fecundity, ovulation, defecation and body morphology. In body wall muscles, regulates organization of myosin thick filaments downstream of unc-89. Ass [...] (192 aa)
max-2Serine/threonine-protein kinase max-2; Serine/threonine-protein kinase, which phosphorylates mlk-1. Involved in the stress response to heavy metals by activating the mlk- 1/mek-1/kgb-1 pathway. In ventral cord commissural motoneurons, required for dorsal axon guidance downstream of unc- 6/netrin repulsion receptor unc-5 and probably of Rho GTPases ced-10 and mig-2. Plays a redundant role with mig-10 in orientating axonal growth of HSN neurons. Plays a redundant role with pak-1 in P neuroblast migration and in distal tip cell (DTC)-mediated guidance of gonad elongation probably downstre [...] (649 aa)
rgs-4RGS domain-containing protein. (216 aa)
pcn-1Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (263 aa)
dkf-1Serine/threonine-protein kinase dkf-1; Converts transient diacylglycerol (DAG) signals into prolonged physiological effects, independently of PKC. Role in the regulation of growth and neuromuscular control of movement. Involved in immune response to S.aureus bacterium by activating transcription factor hlh-30 downstream of phospholipase plc-1. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PKD subfamily. (722 aa)
atn-1AcTiniN. (920 aa)
ZK970.8Uncharacterized protein. (143 aa)
deb-1Vinculin; Involved in cell adhesion. May be involved in the attachment of the actin-based microfilaments to the plasma membrane. Involved in ovulation. (1090 aa)
afd-1PDZ domain-containing protein. (1660 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
Server load: low (36%) [HD]