STRINGSTRING
daf-3 daf-3 flp-16 flp-16 flp-6 flp-6 nlp-9 nlp-9 nlp-14 nlp-14 nlp-15 nlp-15 insc-1 insc-1 agr-1 agr-1 wrk-1 wrk-1 hst-3.1 hst-3.1 nlp-47 nlp-47 jkk-1 jkk-1 nlp-5 nlp-5 ccdc-149 ccdc-149 F21G4.1 F21G4.1 flp-21 flp-21 ins-34 ins-34 nid-1 nid-1 tag-234 tag-234 ins-17 ins-17 unc-43 unc-43 nlp-12 nlp-12 ins-22 ins-22 flp-19 flp-19 daf-16 daf-16 mbr-1 mbr-1 eri-1 eri-1 ins-6 ins-6 lin-15B lin-15B ins-7 ins-7 set-30 set-30 tag-273 tag-273 daf-2 daf-2 ndnf-1 ndnf-1 fog-1 fog-1 slo-1 slo-1 flp-18 flp-18 nlp-25 nlp-25 flp-14 flp-14 lpr-5 lpr-5 pqn-73 pqn-73 nlp-2 nlp-2 ptr-15 ptr-15 unc-86 unc-86 cpb-2 cpb-2 cpb-1 cpb-1 nhr-120 nhr-120 flp-4 flp-4 flp-12 flp-12 jnk-1 jnk-1 cpb-3 cpb-3 daf-7 daf-7 flp-27 flp-27 nlp-20 nlp-20
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
daf-3Dwarfin sma. (895 aa)
flp-16FMRFamide-like neuropeptides 16; FMRFamides and FMRFamide-like peptides are neuropeptides. AQTFVRF-amide inhibits the activity of dissected pharyngeal myogenic muscle system. (92 aa)
flp-6FMRFamide-like neuropeptides 6; FMRFamides and FMRFamide-like peptides are neuropeptides. KSAYMRF-amide has an excitatory effect on dissected pharyngeal myogenic muscle system; Belongs to the FARP (FMRFamide related peptide) family. (170 aa)
nlp-9Neuropeptide-Like Protein. (129 aa)
nlp-14Neuropeptide-Like Protein. (224 aa)
nlp-15Neuropeptide-Like Protein. (143 aa)
insc-1INSCuteable (Drososphila asymmetric cell division protein) homolog. (715 aa)
agr-1AGRin (Synaptic protein) homolog family member. (1473 aa)
wrk-1Wrapper/Rega-1/Klingon homolog. (452 aa)
hst-3.1Sulfotransfer_1 domain-containing protein. (307 aa)
nlp-47Neuropeptide-Like Protein. (89 aa)
jkk-1Dual specificity mitogen-activated protein kinase kinase jkk-1; Dual specificity protein kinase which acts as an essential component of the JNK signal transduction pathway. May phosphorylate jnk-1. Plays a role in coordinating locomotion via D-type GABAergic motoneurons and in regulating synaptic vesicle transport downstream of adapter protein unc-16 and probably by activating jnk-1. Positively regulates lifespan. Upon environmental stress such as heat stress regulates daf-16 nuclear translocation probably by activating jnk-1. Regulates germline cell apoptosis in response to heavy meta [...] (435 aa)
nlp-5Neuropeptide-Like Protein. (123 aa)
ccdc-149Coiled-coil domain-containing protein 149; Belongs to the CCDC149 family. (369 aa)
F21G4.1Solute carrier organic anion transporter family member. (640 aa)
flp-21FMRF-Like Peptide. (66 aa)
ins-34INSulin related. (138 aa)
nid-1NIDogen (Basement membrane protein). (1584 aa)
tag-234Uncharacterized protein. (111 aa)
ins-17Insulin-like peptide 17; Involved in the regulation of the larval diapause. (108 aa)
unc-43Calcium/calmodulin-dependent protein kinase type II; Acts in the signaling of a variety of pathways and processes. Phosphorylates 'Ser-319' of daf-16 in response to stress signals, such as heat, starvation and oxidation, which plays a role in prolonging lifespan. Required for viability under chronic osmotic stress in which it acts downstream of osr-1. Has roles in locomotion, oocyte maturation, brood size, egg laying, defecation, meiotic maturation and neuronal cell fate specification. Required for the regulation of synaptic density and neuromuscular junction morphology. Regulates the [...] (681 aa)
nlp-12Neuropeptide-Like Protein. (80 aa)
ins-22Probable insulin-like peptide alpha-type 2. (83 aa)
flp-19FMRFamide-like neuropeptides 19; FMRFamides and FMRFamide-like peptides are neuropeptides. WANQVRF-amide inhibits the activity of dissected pharyngeal myogenic muscle system; Belongs to the FARP (FMRFamide related peptide) family. (89 aa)
daf-16Forkhead box protein O; Forkhead-type transcription factor. Binds to the promoters of genes that contain the daf-16 binding element (DBE), TTGTTTAC, in their regulatory region. Functions in the Insulin/IGF-1-like signaling (IIS) mediated pathway which affects lipogenesis, lifespan, starvation survival, heat shock and oxidative stress responses, and dauer formation. Longevity signaling predominantly arises from expression in the intestine. Daf-16 transcriptional activity is negatively regulated by cytoplasmic sequestration by association with ftt-2. Inhibition is required for the carbon [...] (541 aa)
mbr-1Mblk-1-related factor 1; May act as transcription activator (By similarity). Plays a role in neurogenesis by regulating neurite pruning between left and right AIM neurons and left and right RIF neurons during larval development. Regulates olfactory plasticity. (433 aa)
eri-13'-5' exonuclease eri-1; RNA exonuclease that acts as a negative regulator of RNA interference (RNAi). Probably acts by degrading the 3'-overhangs of short interfering RNAs (siRNAs). Its tissue specificity may help explain the inefficiency of neuronal RNAi. (582 aa)
ins-6Probable insulin-like peptide beta-type 5; Probable insulin-like peptide which negatively regulates synapse development at the neuromuscular junctions. Probably acts as a daf-2/InsR agonist ligand to prevent dauer formation under optimal environmental conditions. Acts on AWC sensory neurons to regulate high salt chemotaxis responses. (112 aa)
lin-15BProtein lin-15B; Synthetic multivulva (synMuv) class B protein. SynMuv proteins are required to repress the induction of vulval development. Acts redundantly with SynMuv class A protein lin-15A to negatively regulate vulval development. Regulates let-23 basal activity. (1440 aa)
ins-7Probable insulin-like peptide beta-type 4. (116 aa)
set-30MYND-type domain-containing protein. (560 aa)
tag-273LIM zinc-binding domain-containing protein. (891 aa)
daf-2Insulin-like receptor subunit alpha; Insulin receptor-like tyrosine kinase which regulates metabolism, controls longevity and prevents developmental arrest at the dauer stage. Binding of INS family members may either stimulate, or antagonize, association of the receptor with downstream mediators such as pdk-1 and age-1. Required for germline progenitor proliferation during larval development. Required for the response to environmental stimuli such as food, pheromone, and temperature. Negatively regulates resistance to UV and oxidative stress. Role in immune function and pathogen resist [...] (1928 aa)
ndnf-1NDNF (Neuron Derived Neurotrophic Factor) homolog. (536 aa)
fog-1RRM domain-containing protein. (619 aa)
slo-1Calcium-activated potassium channel slo-1; Potassium channel activated by both membrane depolarization or increase in cytosolic Ca(2+) that mediates export of K(+). Its activation dampens the excitatory events that elevate the cytosolic Ca(2+) concentration and/or depolarize the cell membrane. It therefore contributes to repolarization of the membrane potential. Essential for the regulation of neurotransmitter release at synapses. (1160 aa)
flp-18FMRFamide-like neuropeptide 18; Together with flp-1, plays a homeostatic role by acting on the GABAergic neural transmission at neuromuscular junctions to prevent overexcitation of the locomotor circuit. Plays a role in the navigational capacity of sperm and the targeting of sperm derived from males to the fertilization site in the uterus of hermaphrodites. [EMPGVLRF-amide]: Inhibits the activity of dissected pharyngeal myogenic muscle system. (208 aa)
nlp-25Neuropeptide-Like Protein. (87 aa)
flp-14FMRFamide-like neuropeptides 14; FMRFamides and FMRFamide-like peptides are neuropeptides. KHEYLRF-amide has an excitatory effect on dissected pharyngeal myogenic muscle system. Functions in RID peptidergic neurons to promote forward locomotory behavior. (143 aa)
lpr-5LiPocalin-Related protein. (565 aa)
pqn-73Prion-like-(Q/N-rich)-domain-bearing protein. (832 aa)
nlp-2Neuropeptide-Like Protein. (171 aa)
ptr-15SSD domain-containing protein. (840 aa)
unc-86Transcription factor unc-86; Transcription factor required for correct cell fate determination and differentiation in diverse neuronal cell lineages where it plays a role in specifying the fate of daughter cells during cell divisions. Involved in sensory neuron production and function. Binds both alone and with mec-3 to the mec-3 promoter to initiate and maintain mec-3 expression which is required for sensory neuron differentiation. In addition, binds both alone and with mec-3 to the promoters of mec-4 and mec-7 which act to regulate sensory neuron function. Involved in determining the [...] (357 aa)
cpb-2Cytoplasmic polyadenylation element-binding protein 2; Cytoplasmic polyadenylation element binding protein that binds to and regulates the translation of specific mRNAs (By similarity). Not required for oogenesis. (570 aa)
cpb-1Cytoplasmic polyadenylation element-binding protein 1; Cytoplasmic polyadenylation element binding protein that binds to and regulates the translation of specific mRNAs. Essential for progression through meiosis. Involved in spermatogenesis. (560 aa)
nhr-120Nuclear Hormone Receptor family. (477 aa)
flp-4FMRFamide-like peptide 4. (93 aa)
flp-12FMRFamide-like peptide 12. (85 aa)
jnk-1Stress-activated protein kinase jnk-1; Serine/threonine-protein kinase which responds to activation by environmental stress by phosphorylating a number of transcription factors such as daf-16, and thus regulates transcriptional activity. By phosphorylating daf-16, plays a role in daf-16 nuclear translocation in intestinal cells in response to environmental stresses such as heat and oxidative stresses. Downstream of jkk-1, may coordinate locomotion via type-D GABAergic motoneurons and regulates synaptic vesicle transport in conjunction with unc-16. Independently of jkk-1, may regulate s [...] (463 aa)
cpb-3Cytoplasmic polyadenylation element-binding protein 3; Cytoplasmic polyadenylation element binding protein that binds to and regulates the translation of specific mRNAs (By similarity). May not be required for oogenesis. (745 aa)
daf-7Dauer larva development regulatory growth factor daf-7; May act as a negative regulator of dauer larva development by transducing chemosensory information from ASI neurons. Involved in sensitivity to CO2 levels. (350 aa)
flp-27FMRFamide-like neuropeptides 27; FMRFamides and FMRFamide-like peptides are neuropeptides. Belongs to the FARP (FMRFamide related peptide) family. (89 aa)
nlp-20Neuropeptide-Like Protein. (99 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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