STRINGSTRING
T25E4.1 T25E4.1 sop-2 sop-2 D2096.6 D2096.6 rrf-3 rrf-3 nhr-25 nhr-25 nmgp-1 nmgp-1 sax-2 sax-2 ubc-9 ubc-9 ama-1 ama-1 F41H10.5 F41H10.5 cpn-4 cpn-4 dpy-17 dpy-17 myo-5 myo-5 smo-1 smo-1 rol-6 rol-6 T12A7.6 T12A7.6 pqn-71 pqn-71 gei-17 gei-17 nfyb-1 nfyb-1 unc-32 unc-32
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
T25E4.1Uncharacterized protein T25E4.1. (231 aa)
sop-2Polycomb protein sop-2; Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. Also required to repress expression of other genes and for localization of sor-1. Binds RNA. (737 aa)
D2096.6Uncharacterized protein D2096.6. (171 aa)
rrf-3RNA-dependent RNA polymerase Family. (1765 aa)
nhr-25Nuclear hormone receptor family member nhr-25; Orphan nuclear receptor required during development. Plays a role in male tail tip morphogenesis regulating the expression of the transcription factor dmd-3 in a negative feedback loop. (572 aa)
nmgp-1Neuronal Membrane GlycoProtein. (275 aa)
sax-2Sensory AXon guidance. (2886 aa)
ubc-9SUMO-conjugating enzyme UBC9; Accepts the ubiquitin-like protein smo-1 from the aos-1-uba-2 E1 complex and catalyzes its covalent attachment to other proteins with the help of an E3 ligase such as gei-17. Required to sumoylate the ETS transcription factor lin-1 and the Polycomb protein sop-2. Required for embryonic development, fertility, vulval morphogenesis and inhibition of vulval cell fates. Belongs to the ubiquitin-conjugating enzyme family. (166 aa)
ama-1DNA-directed RNA polymerase II subunit RPB1; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Forms the polymerase active center together with the second largest subunit. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB1 is part of the core element with the central large cl [...] (1856 aa)
F41H10.5TLC domain-containing protein. (277 aa)
cpn-4Calponin-homology (CH) domain-containing protein. (154 aa)
dpy-17Col_cuticle_N domain-containing protein. (352 aa)
myo-5MYOsin heavy chain structural genes; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1974 aa)
smo-1Small ubiquitin-related modifier; Ubiquitin-like protein which can be covalently attached to target lysines as a monomer. Does not seem to be involved in protein degradation and may function as an antagonist of ubiquitin in the degradation process. Plays a role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Covalent attachment to its substrates requires prior activation by the E1 complex aos-1-uba-2 and linkage to the E2 enzyme ubc-9, and can be promoted by an E3 ligase such as gei-17. Required for embryonic dev [...] (91 aa)
rol-6Cuticle collagen rol-6; Nematode cuticles are composed largely of collagen-like proteins. The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment. Involved in body morphogenesis. (348 aa)
T12A7.6Uncharacterized protein. (402 aa)
pqn-71Prion-like-(Q/N-rich)-domain-bearing protein. (330 aa)
gei-17E3 SUMO-protein ligase gei-17; Functions as an E3-type smo-1 ligase. Mediates smo-1 conjugation to air-2 in vitro and is required for proper chromosome alignment. In the early embryo, specifically suppresses checkpoint activation in response to DNA damage, maybe by promoting mus-101 sumoylation. In embryos, plays a role in determining telomere localization in the nucleus. (780 aa)
nfyb-1CBFD_NFYB_HMF domain-containing protein. (403 aa)
unc-32Probable V-type proton ATPase 116 kDa subunit a; Required for assembly and activity of the vacuolar ATPase. Potential role in differential targeting and regulation of the enzyme for a specific organelle (Probable). Regulates the size of gut granules during embryonic development. (905 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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