STRINGSTRING
kin-1 kin-1 gpx-5 gpx-5 gpx-3 gpx-3 gpx-1 gpx-1 gpx-8 gpx-8 cwn-1 cwn-1 gpx-7 gpx-7 gpx-2 gpx-2 daf-16 daf-16 gpx-6 gpx-6 gpx-4 gpx-4 let-23 let-23
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
kin-1cAMP-dependent protein kinase catalytic subunit; Essential for larval development. Controls the rhythmic contraction of enteric muscles probably by regulating G- protein coupled receptor aex-2-mediated calcium influx in GABAergic DVB neurons. Plays a role in the control of oocyte meiotic maturation by gonadal sheath cells. Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily. (579 aa)
gpx-5Glutathione peroxidase; Belongs to the glutathione peroxidase family. (223 aa)
gpx-3Glutathione peroxidase 3; Belongs to the glutathione peroxidase family. (224 aa)
gpx-1Glutathione peroxidase 1; May constitute a glutathione peroxidase-like protective system against oxidative stresses. (163 aa)
gpx-8Glutathione PeroXidase. (145 aa)
cwn-1Protein Wnt-1; Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters. Binds receptor tyrosine kinase cam-1. Together with Wnt ligand cwn-2, regulates the migration of CAN, ALM, BDU and HSN neurons during embryogenesis, the migration of QL and QR neuroblast descendants during larval development, and polarity of ALM neurons. Also acts with the Wnt ligand egl-20 to direct HSN neuron migration. Acts [...] (372 aa)
gpx-7Glutathione peroxidase; Belongs to the glutathione peroxidase family. (197 aa)
gpx-2Glutathione peroxidase 2; May constitute a glutathione peroxidase-like protective system against oxidative stresses. (179 aa)
daf-16Forkhead box protein O; Forkhead-type transcription factor. Binds to the promoters of genes that contain the daf-16 binding element (DBE), TTGTTTAC, in their regulatory region. Functions in the Insulin/IGF-1-like signaling (IIS) mediated pathway which affects lipogenesis, lifespan, starvation survival, heat shock and oxidative stress responses, and dauer formation. Longevity signaling predominantly arises from expression in the intestine. Daf-16 transcriptional activity is negatively regulated by cytoplasmic sequestration by association with ftt-2. Inhibition is required for the carbon [...] (541 aa)
gpx-6Glutathione peroxidase; Belongs to the glutathione peroxidase family. (188 aa)
gpx-4Glutathione peroxidase; Belongs to the glutathione peroxidase family. (126 aa)
let-23Receptor tyrosine-protein kinase let-23; Tyrosine-protein kinase receptor which, upon binding ligand lin-3, activates 2 signaling cascades: the let-60/Ras and MAP kinase signaling pathway and the let-60-independent phospholipase C-mediated Ca(2+) signaling pathway. Each pathway regulates distinct functions. By activating let-60/Ras, regulates larval development, induction of vulva cell precursors during vulva development, male spicule formation and posterior development of the epidermis. Probably by activating phospholipase plc-3 and inositol 1,4,5-trisphosphate receptor itr-1 signalin [...] (1335 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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