STRINGSTRING
nhr-10 nhr-10 rbm-26 rbm-26 nhr-23 nhr-23 acdh-2 acdh-2 hel-1 hel-1 elt-2 elt-2 acdh-1 acdh-1 hbl-1 hbl-1 lin-26 lin-26 bed-3 bed-3 ceh-24 ceh-24 let-607 let-607 nhr-68 nhr-68 nhr-101 nhr-101 rde-1 rde-1 gpd-3 gpd-3 gpd-2 gpd-2 mai-1 mai-1 unc-119 unc-119 rol-6 rol-6 Y111B2A.10 Y111B2A.10 uaf-2 uaf-2 nhr-114 nhr-114 sbp-1 sbp-1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
nhr-10Nuclear hormone receptor family member nhr-10; Orphan nuclear receptor; Belongs to the nuclear hormone receptor family. (395 aa)
rbm-26C3H1-type domain-containing protein. (721 aa)
nhr-23Nuclear hormone receptor family member nhr-23; Orphan nuclear receptor; Belongs to the nuclear hormone receptor family. NR1 subfamily. (588 aa)
acdh-2Acyl CoA DeHydrogenase. (386 aa)
hel-1Spliceosome RNA helicase DDX39B homolog; Required for mRNA export out of the nucleus. May play a role in spliceosome assembly. (425 aa)
elt-2Transcription factor elt-2; Transcriptional activator that binds to the consensus sequence 5'-[AT]GATA[AG]-3'. Predominantly directs the transcription of intestinal genes such as ges-1, cpr-6, pho-1, ftn-1 and lev-11, and itself. Required for gut-specific differentiation, specifically acting with the GATA region-binding transcription factor elt-7 to control normal gene expression and promote normal formation of the intestine. Regulates intestinal gene expression in response to hypoxia to promote longevity. Regulates tissue specific gene expression at basal levels and in response to bac [...] (433 aa)
acdh-1Acyl CoA DeHydrogenase. (427 aa)
hbl-1Hunchback-like protein; Required for the late stages of development. Plays a role in the developmental timing of postembryonic hypodermal seam cell fusion events and adult alae production. (982 aa)
lin-26Transcription factor lin-26; Presumed to be a transcription factor required to specify the fates of hypodermal and neuron-associated support cells. Functions during vulval development, playing a role in vulval precursor cell fate specification. (490 aa)
bed-3Zinc finger BED domain-containing protein 3; Probable transcription factor involved in vulval organogenesis. During vulval development, may play a role in the regulation of cell cycle regulators such as cul-1. Plays a role in larval molting. (599 aa)
ceh-24Homeobox protein ceh-24; Probable transcriptional regulator that is required in neural development for the normal formation of sublateral cholinergic motor neuron processes. Plays a role in regulating the expression of acetylcholine transporter protein unc-17 in the sublateral processes. In particular, it is required in sublateral motor neurons for a left- right turning behavior that occurs during the lethargus phase of the normal sleep process called 'flipping'. During 'flipping' animals rotate 180 degrees about their longitudinal axis. (299 aa)
let-607BZIP domain-containing protein. (690 aa)
nhr-68NR LBD domain-containing protein. (385 aa)
nhr-101Nuclear Hormone Receptor family. (391 aa)
rde-1RNA interference promoting factor RDE-1. (1020 aa)
gpd-3Glyceraldehyde-3-phosphate dehydrogenase 3. (341 aa)
gpd-2Glyceraldehyde-3-phosphate dehydrogenase 2. (341 aa)
mai-1ATPase inhibitor mai-1, mitochondrial; Thought to be a regulatory component of the ATP-synthesizing complex in the mitochondria. (88 aa)
unc-119Protein unc-119; Myristoyl-binding protein that acts as a cargo adapter: specifically binds the myristoyl moiety of a subset of N-terminally myristoylated proteins and is required for their localization. Plays a key role in ciliary membrane localization of proteins. Required for the establishment or function of the nervous system. (244 aa)
rol-6Cuticle collagen rol-6; Nematode cuticles are composed largely of collagen-like proteins. The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment. Involved in body morphogenesis. (348 aa)
Y111B2A.10Uncharacterized protein. (430 aa)
uaf-2U2AF splicing factor. (285 aa)
nhr-114NR LBD domain-containing protein; Belongs to the nuclear hormone receptor family. (418 aa)
sbp-1BHLH domain-containing protein. (1113 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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