STRINGSTRING
sph-1 sph-1 clp-8 clp-8 rab-3 rab-3 efn-2 efn-2 rpm-1 rpm-1 cul-1 cul-1 clp-7 clp-7 clp-6 clp-6 clp-3 clp-3 clp-4 clp-4 ric-4 ric-4 clp-10 clp-10 act-5 act-5 clp-9 clp-9 chin-1 chin-1 clp-2 clp-2 cul-6 cul-6 ced-6 ced-6
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
sph-1MARVEL domain-containing protein. (227 aa)
clp-8Calpain catalytic domain-containing protein; Belongs to the peptidase C2 family. (646 aa)
rab-3Ras-related protein Rab-3; Involved in exocytosis by regulating a late step in synaptic vesicle fusion. Could play a role in neurotransmitter release by regulating membrane flow in the nerve terminal (By similarity). Plays a role in the recruitment of endophilin unc-57 to synaptic vesicles. Probably by controlling dense-core vesicle trafficking, plays a role in the AVG neuron-mediated formation of the right axon tract of the ventral nerve cord. Belongs to the small GTPase superfamily. Rab family. (233 aa)
efn-2Ephrin RBD domain-containing protein; Belongs to the ephrin family. (218 aa)
rpm-1E3 ubiquitin-protein ligase rpm-1; Atypical E3 ubiquitin-protein ligase which specifically mediates ubiquitination of threonine and serine residues on target proteins, instead of ubiquitinating lysine residues (By similarity). Shows esterification activity towards both threonine and serine, with a preference for threonine, and acts via two essential catalytic cysteine residues that relay ubiquitin to its substrate via thioester intermediates (By similarity). Mediates ubiquitination and subsequent proteasomal degradation of target proteins, including dlk-1. Negatively regulates a p38 MA [...] (3766 aa)
cul-1Cullin-1; Probable core component of multiple cullin-RING-based SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. Required for developmentally programmed transitions from the G1 phase of the cell cycle to the G0 phase or the apoptotic pathway. (780 aa)
clp-7Calpain catalytic domain-containing protein; Belongs to the peptidase C2 family. (778 aa)
clp-6Calpain catalytic domain-containing protein; Belongs to the peptidase C2 family. (627 aa)
clp-3Calpain catalytic domain-containing protein; Belongs to the peptidase C2 family. (752 aa)
clp-4Calpain catalytic domain-containing protein; Belongs to the peptidase C2 family. (716 aa)
ric-4Synaptosomal-associated protein; Belongs to the SNAP-25 family. (234 aa)
clp-10Calpain catalytic domain-containing protein; Belongs to the peptidase C2 family. (634 aa)
act-5ACTin. (375 aa)
clp-9Calpain catalytic domain-containing protein; Belongs to the peptidase C2 family. (718 aa)
chin-1CHImaeriN (Rac-GTPase-activating protein) homolog. (421 aa)
clp-2Calpain catalytic domain-containing protein; Belongs to the peptidase C2 family. (805 aa)
cul-6Cullin-6; Probable core component of cullin-based SCF-like E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. (729 aa)
ced-6Cell death protein 6; May function as an adapter protein in a pathway that mediates recognition and phagocytosis of apoptotic cells during normal development. Promotes engulfment of cells at both early and late stages of apoptosis. Required for actin reorganization around apoptotic cells. Belongs to the ced-6 family. (492 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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