STRINGSTRING
ace-4 ace-4 gpx-5 gpx-5 gpx-3 gpx-3 gpx-1 gpx-1 gpx-8 gpx-8 gst-4 gst-4 gpx-7 gpx-7 gpx-2 gpx-2 daf-16 daf-16 rol-6 rol-6 gpx-6 gpx-6 ace-1 ace-1 ace-2 ace-2 gpx-4 gpx-4 cha-1 cha-1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ace-4Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (602 aa)
gpx-5Glutathione peroxidase; Belongs to the glutathione peroxidase family. (223 aa)
gpx-3Glutathione peroxidase 3; Belongs to the glutathione peroxidase family. (224 aa)
gpx-1Glutathione peroxidase 1; May constitute a glutathione peroxidase-like protective system against oxidative stresses. (163 aa)
gpx-8Glutathione PeroXidase. (145 aa)
gst-4Glutathione S-transferase 4; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles (By similarity). May play a role in the detoxification of reactive oxygen species produced during pathogenic bacterial infection. (207 aa)
gpx-7Glutathione peroxidase; Belongs to the glutathione peroxidase family. (197 aa)
gpx-2Glutathione peroxidase 2; May constitute a glutathione peroxidase-like protective system against oxidative stresses. (179 aa)
daf-16Forkhead box protein O; Forkhead-type transcription factor. Binds to the promoters of genes that contain the daf-16 binding element (DBE), TTGTTTAC, in their regulatory region. Functions in the Insulin/IGF-1-like signaling (IIS) mediated pathway which affects lipogenesis, lifespan, starvation survival, heat shock and oxidative stress responses, and dauer formation. Longevity signaling predominantly arises from expression in the intestine. Daf-16 transcriptional activity is negatively regulated by cytoplasmic sequestration by association with ftt-2. Inhibition is required for the carbon [...] (541 aa)
rol-6Cuticle collagen rol-6; Nematode cuticles are composed largely of collagen-like proteins. The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment. Involved in body morphogenesis. (348 aa)
gpx-6Glutathione peroxidase; Belongs to the glutathione peroxidase family. (188 aa)
ace-1Acetylcholinesterase 1; Rapidly hydrolyzes choline released into the synapse. It can hydrolyze butyrylthiocholine. (620 aa)
ace-2Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (629 aa)
gpx-4Glutathione peroxidase; Belongs to the glutathione peroxidase family. (126 aa)
cha-1Choline O-acetyltransferase; Catalyzes the reversible synthesis of acetylcholine (ACh) from acetyl CoA and choline at cholinergic synapses (By similarity). Required in SIA sublateral cholinergic motor neurons for a left-right turning behavior that occurs during the lethargus phase of the normal sleep process called 'flipping'. During 'flipping' animals rotate 180 degrees about their longitudinal axis ; Belongs to the carnitine/choline acetyltransferase family. (627 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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