STRINGSTRING
dgat-2 dgat-2 daf-12 daf-12 lips-10 lips-10 fasn-1 fasn-1 fem-1 fem-1 mlcd-1 mlcd-1 gst-24 gst-24 pha-4 pha-4 lipl-2 lipl-2 lipl-1 lipl-1 lys-4 lys-4 nhr-80 nhr-80 lipl-5 lipl-5 tcer-1 tcer-1 mrps-23 mrps-23 atfs-1 atfs-1 lin-17 lin-17 Y53G8B.2 Y53G8B.2 Y45F10D.4 Y45F10D.4 pod-2 pod-2 hlh-30 hlh-30 dgtr-1 dgtr-1 rpl-32 rpl-32 atg-9 atg-9 skn-1 skn-1 pcf-11 pcf-11 daf-16 daf-16 mdt-15 mdt-15 hacd-1 hacd-1 mtl-1 mtl-1 nhr-49 nhr-49 K07B1.4 K07B1.4 lipl-4 lipl-4 mboa-2 mboa-2 atgl-1 atgl-1 eif-6 eif-6 acs-22 acs-22 numr-2 numr-2 numr-1 numr-1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
dgat-2Acyl-CoA:DiacylGlycerol AcylTransferase. (345 aa)
daf-12Nuclear hormone receptor family member daf-12; Nuclear receptor which binds directly to response elements in target gene promoters. Activity is modulated by binding of steroid hormone ligands that include dafachronic acids. Regulates expression of genes involved in postembryonic development and the dauer diapause, in response to environmental cues. Inhibits the expression of let-7 family members when bound to corepressor din-1s which is an isoform of din-1. Has a role in the immune response to bacterial infection, via regulation of let-7 miRNAs. Controls expression of genes that promot [...] (753 aa)
lips-10LIPaSe related. (281 aa)
fasn-1Carrier domain-containing protein. (2613 aa)
fem-1Sex-determining protein fem-1; Sex-determining protein; essential for the adoption of the male sexual fate in all tissues. Substrate recognition subunit of the cullin-RING-based CBC(fem-1) (Cul2-ElonginB-ElonginC) E3 ubiquitin- protein ligase complex which mediates in association with cofactors fem-2 and fem-3 the ubiquitination and subsequent proteasomal degradation of tra-1. (656 aa)
mlcd-1MaLonyl CoA Decarboxylase. (442 aa)
gst-24Glutathione S-Transferase. (209 aa)
pha-4Defective pharyngeal development protein 4; Acts as a transcription factor required for formation of the pharyngeal primordium. Binds to the consensus sequence 5'-T[AG]TT[TG][AG][TC]-3' with variations of the sequence affecting onset of target gene expression. Activates a wide array of pharyngeal genes including ceh-22 and myo-2 and represses ectodermal genes lin-26 and elt-3, ensuring pharyngeal cell fate. Required for recruitment of htz-1 to a subset of pharyngeal promoters to ensure gene activation and also acts synergistically with tbx-2 in pharyngeal development. Acts in the regul [...] (506 aa)
lipl-2Lipase; Belongs to the AB hydrolase superfamily. Lipase family. (411 aa)
lipl-1Lipase; Belongs to the AB hydrolase superfamily. Lipase family. (405 aa)
lys-4LYSozyme. (214 aa)
nhr-80Nuclear Hormone Receptor family. (504 aa)
lipl-5Lipase; Belongs to the AB hydrolase superfamily. Lipase family. (403 aa)
tcer-1WW domain-containing protein. (914 aa)
mrps-23Probable 28S ribosomal protein S23, mitochondrial; Belongs to the mitochondrion-specific ribosomal protein mS23 family. (133 aa)
atfs-1Stress activated transcription factor atfs-1; Acts as a transcription factor during mitochondrial stress by activating the mitochondrial unfolded protein response (mtUPR). Induces nuclear and mitochondrial gene transcription, including genes coding for mitochondrial chaperones and proteins involved in glycolysis, amino acid catabolism and innate immunity. Following mitochondrial stress, restores mitochondrial respiratory capacity by limiting the transcription of oxidative phosphorylation (OXPHOS) machinery genes and by promoting the assembly of OXPHOS complexes via the up-regulation of [...] (488 aa)
lin-17Transmembrane receptor LIN-17; Belongs to the G-protein coupled receptor Fz/Smo family. (558 aa)
Y53G8B.2Uncharacterized protein. (340 aa)
Y45F10D.4NifU_N domain-containing protein; Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins. (153 aa)
pod-2Uncharacterized protein. (2165 aa)
hlh-30BHLH domain-containing protein. (524 aa)
dgtr-1DGAT (Acyl-CoA:DiacylGlycerol AcylTransferase) Related. (359 aa)
rpl-32Ribosomal Protein, Large subunit. (134 aa)
atg-9Autophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family. (921 aa)
skn-1Protein skinhead-1; Transcription factor required to specify the fate of ventral blastomeres in the early embryo, and postembryonically for the development of the intestine. Directly regulates expression of zygotically expressed med-1 and med-2 to direct mesendoderm development. Required for stl-1 mRNA up- regulation in response to oxidative stress and anoxia. Required for the up-regulation of gcs-1 and several glutathione-S-transferase mRNAs in response to oxidative stress generated during pathogenic bacterial infection. In neurons, involved in mitochondrial fusion and behavioral reco [...] (623 aa)
pcf-11Polyadenylation and cleavage factor homolog 11. (823 aa)
daf-16Forkhead box protein O; Forkhead-type transcription factor. Binds to the promoters of genes that contain the daf-16 binding element (DBE), TTGTTTAC, in their regulatory region. Functions in the Insulin/IGF-1-like signaling (IIS) mediated pathway which affects lipogenesis, lifespan, starvation survival, heat shock and oxidative stress responses, and dauer formation. Longevity signaling predominantly arises from expression in the intestine. Daf-16 transcriptional activity is negatively regulated by cytoplasmic sequestration by association with ftt-2. Inhibition is required for the carbon [...] (541 aa)
mdt-15Mediator of RNA polymerase II transcription subunit 15; Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Require [...] (780 aa)
hacd-1Hydroxy-Acyl-CoA Dehydrogenase. (299 aa)
mtl-1Metallothionein-1; This protein binds cations of several transition elements. (75 aa)
nhr-49Nuclear hormone receptor family member nhr-49; Orphan nuclear receptor. Regulates expression of lipid desaturase, fat-7 ; Belongs to the nuclear hormone receptor family. (501 aa)
K07B1.4Uncharacterized protein. (349 aa)
lipl-4Lipase; Belongs to the AB hydrolase superfamily. Lipase family. (411 aa)
mboa-2O-acyltransferase. (498 aa)
atgl-1Patanin-like phospholipase domain-containing protein; Catalyzes the initial step in triglyceride hydrolysis in adipocyte and non-adipocyte lipid droplets (By similarity). May play a role in the response of the organism to starvation, enhancing hydrolysis of triglycerides and providing free fatty acids to other tissues to be oxidized in situations of energy depletion. Acts coordinately with lid-1 within the lipolytic cascade to distribute stored energy to tissues. Together with lipid droplet protein cgi-58, regulates lipid reserves as well as lipid droplet size and localization during t [...] (751 aa)
eif-6Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis. Involved in miRNA-mediated gene silencing. (246 aa)
acs-22Fatty Acid CoA Synthetase family. (655 aa)
numr-2NUclear localized Metal Responsive. (281 aa)
numr-1NUclear localized Metal Responsive. (281 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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