STRINGSTRING
act-5 act-5 pha-1 pha-1 rol-1 rol-1 unc-52 unc-52 unc-54 unc-54 vab-3 vab-3 lin-26 lin-26 unc-4 unc-4 dpy-5 dpy-5 pax-3 pax-3 dpy-7 dpy-7 elt-6 elt-6 egl-18 egl-18 elt-3 elt-3 pax-2 pax-2 pax-1 pax-1 unc-119 unc-119 his-24 his-24 rol-6 rol-6 tbx-8 tbx-8 tbx-9 tbx-9 unc-29 unc-29 dpy-10 dpy-10 dpy-20 dpy-20 elt-1 elt-1 egl-38 egl-38 lin-39 lin-39 bli-1 bli-1 ajm-1 ajm-1 aff-1 aff-1 ced-3 ced-3 grd-10 grd-10 nhr-25 nhr-25
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
act-5ACTin. (375 aa)
pha-1Pha-1 protein. (491 aa)
rol-1Col_cuticle_N domain-containing protein. (458 aa)
unc-52Basement membrane proteoglycan; Component of an integrin containing attachment complex, which is required for muscle development and maintenance. Probable structural role in myofilament assembly and/or attachment of the myofilament lattice to the cell membrane. May be an extracellular anchor for integrin receptors in body wall muscles and myoepithelial sheath cells. During the formation of neuromuscular junctions at the larval stage, negatively regulates membrane protrusion from body wall muscles, probably downstream of the integrin complex formed by pat-2 and pat-3. Involved in ovulation. (3375 aa)
unc-54Myosin-4; Required for muscle contraction. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1963 aa)
vab-3Homeobox domain-containing protein. (455 aa)
lin-26Transcription factor lin-26; Presumed to be a transcription factor required to specify the fates of hypodermal and neuron-associated support cells. Functions during vulval development, playing a role in vulval precursor cell fate specification. (490 aa)
unc-4Homeobox protein unc-4; Transcription factor that regulates synaptic specificity. Determines the pattern of synaptic input to VA motor neurons. Acts together with unc-37 by repressing the expression of VB-specific genes such as ceh-12, thereby preventing the adoption of VB motor neurons. Has no role in axonal guidance or outgrowth. Belongs to the paired homeobox family. Unc-4 subfamily. (252 aa)
dpy-5Cuticle collagen dpy-5; Nematode cuticles are composed largely of collagen-like proteins. The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment. (284 aa)
pax-3PAX (Paired box) transcription factor. (308 aa)
dpy-7Cuticle collagen dpy-7; Nematode cuticles are composed largely of collagen-like proteins. The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment. Mutations in dpy-7 affects the body shape. (318 aa)
elt-6GATA-like transcription factor ELT-6. (367 aa)
egl-18GATA-type domain-containing protein. (379 aa)
elt-3GATA-type domain-containing protein. (317 aa)
pax-2Paired domain-containing protein. (351 aa)
pax-1Paired domain-containing protein. (257 aa)
unc-119Protein unc-119; Myristoyl-binding protein that acts as a cargo adapter: specifically binds the myristoyl moiety of a subset of N-terminally myristoylated proteins and is required for their localization. Plays a key role in ciliary membrane localization of proteins. Required for the establishment or function of the nervous system. (244 aa)
his-24Histone 24; Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures. (208 aa)
rol-6Cuticle collagen rol-6; Nematode cuticles are composed largely of collagen-like proteins. The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment. Involved in body morphogenesis. (348 aa)
tbx-8T-box transcription factor tbx-8; Involved in the control of early morphogenesis of the intestine, hypodermis and body-wall muscle. Appears to have partially redundant function to tbx-9. (315 aa)
tbx-9T-box transcription factor tbx-9; Involved in the control of early morphogenesis of the intestine, hypodermis and body-wall muscle. Appears to have partially redundant function to tbx-8. (292 aa)
unc-29Acetylcholine receptor subunit beta-type unc-29; Non-alpha subunit of nicotinic acetylcholine receptor (nAChR). Involved in nAChR sensitivity to nicotine and levasimole. Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. (493 aa)
dpy-10Cuticle collagen dpy-10; Nematode cuticles are composed largely of collagen-like proteins. The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment. (356 aa)
dpy-20Protein dumpy-20; May be directly or indirectly involved in cuticle function. (440 aa)
elt-1Transcription factor elt-1; Transcriptional activator that binds to the consensus sequence 5'-[AT]GATA[AG]-3' and variations thereof. During embryonic development, required for specification of cell fate of major hypodermal (epidermal) cells at the blastomere stage. The requirement is true for all four lineages derived from ABarp, ABpra and C blastomeres. Required for seam cell maintenance in late embryogenesis, for proper formation of dauer larvae and locomotion. Regulates expression of bro-1, a regulator of seam cell proliferation, via a GATA-like binding motif. Probably represses ex [...] (488 aa)
egl-38Paired domain-containing protein. (289 aa)
lin-39Homeobox protein lin-39; Transcription factor that binds to the consensus 5'- TGATNNAT(G/T)(G/A)-3' PBC/Hox motif of target genes to regulate gene expression. Binds to the consensus PBC/Hox motif lineage enhancer region of sem-2 to promote cell fate specification in the postembryonic mesoderm (also known as the M lineage). Regulates the expression of mig-13 which controls the asymmetric distribution of actin cytoskeleton-binding protein cor-1 in Q neuroblasts. This in turn controls the polarity migration of Q neuroblasts and the subsequent mid-body region-specific development. Belongs [...] (253 aa)
bli-1Cuticle collagen bli-1; Nematode cuticles are composed largely of collagen-like proteins. The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment. This collagen is required for proper strut formation within the unique medial layer of the adult cuticle. (948 aa)
ajm-1Apical junction molecule; Controls adherens junction integrity. Required for the correct rate and completion of elongation of the embryos. (1905 aa)
aff-1Cell fusion protein aff-1; Required for cell fusion events during development including the fusion of anchor cells (AC), vulval A and vulval D rings, and late epidermal seam cells. Required for amphid sheath cell fusion induced by entry into dauer stage. (589 aa)
ced-3Cell death protein 3 subunit p13; Acts as a cysteine protease in controlling programmed cell death (apoptosis) by proteolytically activating or inactivating a wide range of substrates. Component of the egl-1, ced-9, ced-4 and ced-3 apoptotic signaling cascade required for the initiation of programmed cell death in cells fated to die during embryonic and postembryonic development. During oogenesis, required for germline apoptosis downstream of ced-9 and ced-4 but independently of egl-1. By cleaving and activating ced-8, promotes phosphatidylserine exposure on the surface of apoptotic ce [...] (503 aa)
grd-10Ground-like domain-containing protein. (102 aa)
nhr-25Nuclear hormone receptor family member nhr-25; Orphan nuclear receptor required during development. Plays a role in male tail tip morphogenesis regulating the expression of the transcription factor dmd-3 in a negative feedback loop. (572 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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