STRINGSTRING
sra-6 sra-6 sra-9 sra-9 che-12 che-12 daf-7 daf-7 ttbk-5 ttbk-5 daf-37 daf-37 ceh-36 ceh-36 ttbk-6 ttbk-6 srg-47 srg-47 maco-1 maco-1 ins-1 ins-1 ttbk-3 ttbk-3 srg-37 srg-37 srg-36 srg-36 str-3 str-3 ttbk-7 ttbk-7 srbc-66 srbc-66 ttbk-4 ttbk-4 srbc-64 srbc-64 qui-1 qui-1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
sra-6Serpentine receptor class alpha-6. (329 aa)
sra-9Serpentine receptor class alpha-9. (331 aa)
che-12Crescerin-like protein che-12; Required for normal structure and function of sensory cilia on amphid neurons, especially for the formation of distal ciliary structures, but is less important for normal assembly of middle and basal ciliary structures. Plays a role in the organization of axoneme microtubule bundles in sensory cilia. Required for normal structure and function of the ASER neuron that mediates attraction to NaCl. Required for normal chemotaxis to NaCl. Required for normal avoidance response to high osmolarity. In contrast, is not required for normal chemotaxis to isoamyl al [...] (1282 aa)
daf-7Dauer larva development regulatory growth factor daf-7; May act as a negative regulator of dauer larva development by transducing chemosensory information from ASI neurons. Involved in sensitivity to CO2 levels. (350 aa)
ttbk-5Protein kinase domain-containing protein. (373 aa)
daf-37G-protein coupled receptor daf-37; G-protein coupled receptor (GPCR) that forms a heterodimer with daf-38 to control dauer formation and behavior. Receptor for the ascaroside pheromone ascr#2. Required for the response to dauer inducing pheromones, specifically the ascaroside ascr#2. May serve neuronal specific roles in response to ascr#2 with expression in ASI neurons controlling dauer formation in larvae, and expression in ASK neurons playing a role in longevity and hermaphrodite repulsion. May function upstream of the daf-11, daf-7 and daf-2 signaling pathways. (482 aa)
ceh-36Homeobox protein ceh-36; Mediates chemosensory function of ASE and AWC neurons. In ASE neurons, required to diversify the fate of the ASEL neurons from the ASER neurons. In cooperation with the transcription factor sox-2, required for the differentiation of AWC olfactory neurons. May regulate the expression of sox-2 in AWC olfactory neurons. Belongs to the paired homeobox family. (257 aa)
ttbk-6Inactive tau-tubulin kinase ttbk-6. (290 aa)
srg-47Serpentine receptor class gamma-47. (309 aa)
maco-1Macoilin; Plays a role in the regulation of neuronal activity. (897 aa)
ins-1IlGF domain-containing protein. (109 aa)
ttbk-3Protein kinase domain-containing protein. (562 aa)
srg-37Serpentine receptor class gamma; Belongs to the nematode receptor-like protein srg family. (324 aa)
srg-36Serpentine receptor class gamma; Belongs to the nematode receptor-like protein srg family. (332 aa)
str-3Seven TM Receptor. (352 aa)
ttbk-7Protein kinase domain-containing protein. (776 aa)
srbc-66Serpentine Receptor, class BC (Class B-like). (286 aa)
ttbk-4Protein kinase domain-containing protein. (366 aa)
srbc-64Serpentine Receptor, class BC (Class B-like). (289 aa)
qui-1WD_REPEATS_REGION domain-containing protein. (1592 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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