node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
acdh-11 | ech-7 | Y45F3A.3a.1 | Y105E8A.4.1 | Acyl-CoA dehydrogenase family member 11; Promotes adaption to elevated temperatures by regulating expression of the lipid desaturase, fat-7. Binds selectively and with high affinity to fatty acids with chain lengths from C10 to C12 and prevents them from activating fat-7 expression mediated by the nuclear hormone receptor nhr-49, leading to low levels of membrane lipid desaturation and membrane fluidity for adaption to heat. | Enoyl-CoA Hydratase; Belongs to the enoyl-CoA hydratase/isomerase family. | 0.891 |
acdh-11 | fat-7 | Y45F3A.3a.1 | F10D2.9.1 | Acyl-CoA dehydrogenase family member 11; Promotes adaption to elevated temperatures by regulating expression of the lipid desaturase, fat-7. Binds selectively and with high affinity to fatty acids with chain lengths from C10 to C12 and prevents them from activating fat-7 expression mediated by the nuclear hormone receptor nhr-49, leading to low levels of membrane lipid desaturation and membrane fluidity for adaption to heat. | Delta(9)-fatty-acid desaturase fat-7; Delta(9)-fatty-acid desaturase that acts preferentially on stearoyl-CoA. Also acts on vaccenyl-coA, heptadecanyol-CoA, and palmitoyl-CoA. | 0.667 |
acdh-11 | hacd-1 | Y45F3A.3a.1 | R09B5.6.1 | Acyl-CoA dehydrogenase family member 11; Promotes adaption to elevated temperatures by regulating expression of the lipid desaturase, fat-7. Binds selectively and with high affinity to fatty acids with chain lengths from C10 to C12 and prevents them from activating fat-7 expression mediated by the nuclear hormone receptor nhr-49, leading to low levels of membrane lipid desaturation and membrane fluidity for adaption to heat. | Hydroxy-Acyl-CoA Dehydrogenase. | 0.868 |
acdh-11 | nhr-49 | Y45F3A.3a.1 | K10C3.6c.2 | Acyl-CoA dehydrogenase family member 11; Promotes adaption to elevated temperatures by regulating expression of the lipid desaturase, fat-7. Binds selectively and with high affinity to fatty acids with chain lengths from C10 to C12 and prevents them from activating fat-7 expression mediated by the nuclear hormone receptor nhr-49, leading to low levels of membrane lipid desaturation and membrane fluidity for adaption to heat. | Nuclear hormone receptor family member nhr-49; Orphan nuclear receptor. Regulates expression of lipid desaturase, fat-7 ; Belongs to the nuclear hormone receptor family. | 0.667 |
acdh-11 | paqr-2 | Y45F3A.3a.1 | Y32H12A.5.1 | Acyl-CoA dehydrogenase family member 11; Promotes adaption to elevated temperatures by regulating expression of the lipid desaturase, fat-7. Binds selectively and with high affinity to fatty acids with chain lengths from C10 to C12 and prevents them from activating fat-7 expression mediated by the nuclear hormone receptor nhr-49, leading to low levels of membrane lipid desaturation and membrane fluidity for adaption to heat. | Progestin and AdipoQ Receptor family. | 0.707 |
acdh-11 | sur-5 | Y45F3A.3a.1 | K03A1.5.2 | Acyl-CoA dehydrogenase family member 11; Promotes adaption to elevated temperatures by regulating expression of the lipid desaturase, fat-7. Binds selectively and with high affinity to fatty acids with chain lengths from C10 to C12 and prevents them from activating fat-7 expression mediated by the nuclear hormone receptor nhr-49, leading to low levels of membrane lipid desaturation and membrane fluidity for adaption to heat. | Acetoacetyl-CoA synthetase; Activates acetoacetate to acetoacetyl-CoA (By similarity). Negatively regulates let-60 Ras activity during vulval induction. Belongs to the ATP-dependent AMP-binding enzyme family. | 0.576 |
cept-1 | ech-7 | F22E10.5a.1 | Y105E8A.4.1 | Choline/EthanolaminePhosphoTransferase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | Enoyl-CoA Hydratase; Belongs to the enoyl-CoA hydratase/isomerase family. | 0.815 |
cept-1 | fat-7 | F22E10.5a.1 | F10D2.9.1 | Choline/EthanolaminePhosphoTransferase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | Delta(9)-fatty-acid desaturase fat-7; Delta(9)-fatty-acid desaturase that acts preferentially on stearoyl-CoA. Also acts on vaccenyl-coA, heptadecanyol-CoA, and palmitoyl-CoA. | 0.577 |
cept-1 | hacd-1 | F22E10.5a.1 | R09B5.6.1 | Choline/EthanolaminePhosphoTransferase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | Hydroxy-Acyl-CoA Dehydrogenase. | 0.662 |
cept-1 | iglr-2 | F22E10.5a.1 | ZC262.3a.1 | Choline/EthanolaminePhosphoTransferase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | Immunoglobulin domain and leucine-rich repeat-containing protein 2. | 0.741 |
cept-1 | mdt-15 | F22E10.5a.1 | R12B2.5a.1 | Choline/EthanolaminePhosphoTransferase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | Mediator of RNA polymerase II transcription subunit 15; Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Require [...] | 0.630 |
cept-1 | nhr-49 | F22E10.5a.1 | K10C3.6c.2 | Choline/EthanolaminePhosphoTransferase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | Nuclear hormone receptor family member nhr-49; Orphan nuclear receptor. Regulates expression of lipid desaturase, fat-7 ; Belongs to the nuclear hormone receptor family. | 0.461 |
cept-1 | paqr-2 | F22E10.5a.1 | Y32H12A.5.1 | Choline/EthanolaminePhosphoTransferase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | Progestin and AdipoQ Receptor family. | 0.692 |
cept-1 | pcyt-1 | F22E10.5a.1 | F08C6.2a.1 | Choline/EthanolaminePhosphoTransferase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | Putative choline-phosphate cytidylyltransferase; Belongs to the cytidylyltransferase family. | 0.950 |
cept-1 | pld-1 | F22E10.5a.1 | C04G6.3.1 | Choline/EthanolaminePhosphoTransferase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | Phospholipase. | 0.484 |
cept-1 | sams-1 | F22E10.5a.1 | C49F5.1.2 | Choline/EthanolaminePhosphoTransferase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | Probable S-adenosylmethionine synthase 1; Catalyzes the formation of S-adenosylmethionine from methionine and ATP. The reaction comprises two steps that are both catalyzed by the same enzyme: formation of S-adenosylmethionine (AdoMet) and triphosphate, and subsequent hydrolysis of the triphosphate; Belongs to the AdoMet synthase family. | 0.696 |
cept-1 | sbp-1 | F22E10.5a.1 | Y47D3B.7.1 | Choline/EthanolaminePhosphoTransferase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | BHLH domain-containing protein. | 0.548 |
daf-16 | daf-2 | R13H8.1h.1 | Y55D5A.5c.2 | Forkhead box protein O; Forkhead-type transcription factor. Binds to the promoters of genes that contain the daf-16 binding element (DBE), TTGTTTAC, in their regulatory region. Functions in the Insulin/IGF-1-like signaling (IIS) mediated pathway which affects lipogenesis, lifespan, starvation survival, heat shock and oxidative stress responses, and dauer formation. Longevity signaling predominantly arises from expression in the intestine. Daf-16 transcriptional activity is negatively regulated by cytoplasmic sequestration by association with ftt-2. Inhibition is required for the carbon [...] | Insulin-like receptor subunit alpha; Insulin receptor-like tyrosine kinase which regulates metabolism, controls longevity and prevents developmental arrest at the dauer stage. Binding of INS family members may either stimulate, or antagonize, association of the receptor with downstream mediators such as pdk-1 and age-1. Required for germline progenitor proliferation during larval development. Required for the response to environmental stimuli such as food, pheromone, and temperature. Negatively regulates resistance to UV and oxidative stress. Role in immune function and pathogen resist [...] | 0.998 |
daf-16 | fat-7 | R13H8.1h.1 | F10D2.9.1 | Forkhead box protein O; Forkhead-type transcription factor. Binds to the promoters of genes that contain the daf-16 binding element (DBE), TTGTTTAC, in their regulatory region. Functions in the Insulin/IGF-1-like signaling (IIS) mediated pathway which affects lipogenesis, lifespan, starvation survival, heat shock and oxidative stress responses, and dauer formation. Longevity signaling predominantly arises from expression in the intestine. Daf-16 transcriptional activity is negatively regulated by cytoplasmic sequestration by association with ftt-2. Inhibition is required for the carbon [...] | Delta(9)-fatty-acid desaturase fat-7; Delta(9)-fatty-acid desaturase that acts preferentially on stearoyl-CoA. Also acts on vaccenyl-coA, heptadecanyol-CoA, and palmitoyl-CoA. | 0.700 |
daf-16 | mdt-15 | R13H8.1h.1 | R12B2.5a.1 | Forkhead box protein O; Forkhead-type transcription factor. Binds to the promoters of genes that contain the daf-16 binding element (DBE), TTGTTTAC, in their regulatory region. Functions in the Insulin/IGF-1-like signaling (IIS) mediated pathway which affects lipogenesis, lifespan, starvation survival, heat shock and oxidative stress responses, and dauer formation. Longevity signaling predominantly arises from expression in the intestine. Daf-16 transcriptional activity is negatively regulated by cytoplasmic sequestration by association with ftt-2. Inhibition is required for the carbon [...] | Mediator of RNA polymerase II transcription subunit 15; Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Require [...] | 0.726 |