(21 nodes) (2016) A Genetic Screen Identifies a Critical Role for the WDR81-WDR91 Complex in the Trafficking and Degradation of Tetherin. network (Caenorhabditis elegans)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	F32H5.1	Pept_C1 domain-containing protein; Belongs to the peptidase C1 family. (356 aa)
	cpr-2	Pept_C1 domain-containing protein; Belongs to the peptidase C1 family. (326 aa)
	cpr-4	Cathepsin B-like cysteine proteinase 4; Thiol protease which shows activity against the fluorogenic substrate z-Arg-Arg-AMC; Belongs to the peptidase C1 family. (335 aa)
	F57F5.1	Pept_C1 domain-containing protein; Belongs to the peptidase C1 family. (351 aa)
	asp-3	Aspartic protease 3; Aspartic protease (Probable). Part of the necrosis cell death pathway. Involved in neuronal cell degeneration. Involved in heat stress response. (398 aa)
	asp-4	Aspartic protease 4; Aspartic protease, which is part of the necrosis cell death pathway. Involved in neuronal cell degeneration. Involved in heat stress response. Belongs to the peptidase A1 family. (444 aa)
	lyst-1	BEACH domain-containing protein. (2760 aa)
	vps-39	Vacuolar protein sorting-associated protein 39 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways (By similarity). Believed to act in part as a component of the putative HOPS endosomal tethering complex which is proposed to be involved in the rab-5-to-rab-7 endosome conversion probably implicating sand-1, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to rab-7 on th [...] (926 aa)
	eea-1	FYVE-type domain-containing protein. (1205 aa)
	vps-18	Vacuolar protein sorting-associated protein 18 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the rab-5-to-rab-7 endosome conversion probably implicating sand-1, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion (By similarity). The HOPS complex is proposed to be recruited to [...] (1026 aa)
	cpr-3	Cathepsin B-like cysteine proteinase 3; Belongs to the peptidase C1 family. (370 aa)
	cpr-8	Pept_C1 domain-containing protein; Belongs to the peptidase C1 family. (335 aa)
	W07B8.4	Pept_C1 domain-containing protein; Belongs to the peptidase C1 family. (335 aa)
	cpr-5	Cathepsin B-like cysteine proteinase 5; Belongs to the peptidase C1 family. (344 aa)
	sorf-1	Suppressor of organelle fusion 1; Together with sorf-2 negatively regulates the levels of phosphatidylinositol 3-phosphate (PtdIns3P) to enable the conversion of early endosomes to late endosomes. Binds to sorf-2 and the sorf-1-sorf- 2 complex likely acts through bec-1, a non-catalytic subunit of phosphatidylinositol 3-kinase (PI3K), to suppress PI3K activity, thereby negatively regulating endosomal PtdIns3P levels. Belongs to the WD repeat WDR91 family. (239 aa)
	vps-34	Phosphatidylinositol 3-kinase catalytic subunit type 3; Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate. Together with bec-1, mediates the production of phosphatidylinositol 3-phosphate on intracellular vesicles and thereby regulates membrane trafficking. Plays a role in endosome-to-Golgi retrograde transport of mig-14. Involved in clearance of apoptotic cell corpses by phagosomes. Phagosome maturation requires two sequential and non-overlapping pulses of phosphatidylinositol-3-phosphate (PI3P) on the vesicle surface which mediates recr [...] (901 aa)
	tsg-101	Tumor Susceptibility Gene homolog. (425 aa)
	cpr-6	Cathepsin B-like cysteine proteinase 6; Belongs to the peptidase C1 family. (379 aa)
	cpr-1	Gut-specific cysteine proteinase; Thiol protease. Has a role as a digestive enzyme. Belongs to the peptidase C1 family. (329 aa)
	cul-1	Cullin-1; Probable core component of multiple cullin-RING-based SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. Required for developmentally programmed transitions from the G1 phase of the cell cycle to the G0 phase or the apoptotic pathway. (780 aa)
	rab-5	RAB family. (208 aa)

Your Current Organism:

Caenorhabditis elegans

NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
F32H5.1	asp-3	F32H5.1.1	H22K11.1.1	Pept_C1 domain-containing protein; Belongs to the peptidase C1 family.	Aspartic protease 3; Aspartic protease (Probable). Part of the necrosis cell death pathway. Involved in neuronal cell degeneration. Involved in heat stress response.	0.940
F32H5.1	asp-4	F32H5.1.1	R12H7.2.1	Pept_C1 domain-containing protein; Belongs to the peptidase C1 family.	Aspartic protease 4; Aspartic protease, which is part of the necrosis cell death pathway. Involved in neuronal cell degeneration. Involved in heat stress response. Belongs to the peptidase A1 family.	0.934
F32H5.1	rab-5	F32H5.1.1	F26H9.6.1	Pept_C1 domain-containing protein; Belongs to the peptidase C1 family.	RAB family.	0.487
F57F5.1	asp-3	F57F5.1.1	H22K11.1.1	Pept_C1 domain-containing protein; Belongs to the peptidase C1 family.	Aspartic protease 3; Aspartic protease (Probable). Part of the necrosis cell death pathway. Involved in neuronal cell degeneration. Involved in heat stress response.	0.980
F57F5.1	asp-4	F57F5.1.1	R12H7.2.1	Pept_C1 domain-containing protein; Belongs to the peptidase C1 family.	Aspartic protease 4; Aspartic protease, which is part of the necrosis cell death pathway. Involved in neuronal cell degeneration. Involved in heat stress response. Belongs to the peptidase A1 family.	0.937
F57F5.1	cpr-1	F57F5.1.1	C52E4.1.1	Pept_C1 domain-containing protein; Belongs to the peptidase C1 family.	Gut-specific cysteine proteinase; Thiol protease. Has a role as a digestive enzyme. Belongs to the peptidase C1 family.	0.670
F57F5.1	cpr-5	F57F5.1.1	W07B8.5.1	Pept_C1 domain-containing protein; Belongs to the peptidase C1 family.	Cathepsin B-like cysteine proteinase 5; Belongs to the peptidase C1 family.	0.613
F57F5.1	rab-5	F57F5.1.1	F26H9.6.1	Pept_C1 domain-containing protein; Belongs to the peptidase C1 family.	RAB family.	0.488
W07B8.4	asp-3	W07B8.4a.1	H22K11.1.1	Pept_C1 domain-containing protein; Belongs to the peptidase C1 family.	Aspartic protease 3; Aspartic protease (Probable). Part of the necrosis cell death pathway. Involved in neuronal cell degeneration. Involved in heat stress response.	0.930
W07B8.4	asp-4	W07B8.4a.1	R12H7.2.1	Pept_C1 domain-containing protein; Belongs to the peptidase C1 family.	Aspartic protease 4; Aspartic protease, which is part of the necrosis cell death pathway. Involved in neuronal cell degeneration. Involved in heat stress response. Belongs to the peptidase A1 family.	0.932
W07B8.4	rab-5	W07B8.4a.1	F26H9.6.1	Pept_C1 domain-containing protein; Belongs to the peptidase C1 family.	RAB family.	0.487
asp-3	F32H5.1	H22K11.1.1	F32H5.1.1	Aspartic protease 3; Aspartic protease (Probable). Part of the necrosis cell death pathway. Involved in neuronal cell degeneration. Involved in heat stress response.	Pept_C1 domain-containing protein; Belongs to the peptidase C1 family.	0.940
asp-3	F57F5.1	H22K11.1.1	F57F5.1.1	Aspartic protease 3; Aspartic protease (Probable). Part of the necrosis cell death pathway. Involved in neuronal cell degeneration. Involved in heat stress response.	Pept_C1 domain-containing protein; Belongs to the peptidase C1 family.	0.980
asp-3	W07B8.4	H22K11.1.1	W07B8.4a.1	Aspartic protease 3; Aspartic protease (Probable). Part of the necrosis cell death pathway. Involved in neuronal cell degeneration. Involved in heat stress response.	Pept_C1 domain-containing protein; Belongs to the peptidase C1 family.	0.930
asp-3	asp-4	H22K11.1.1	R12H7.2.1	Aspartic protease 3; Aspartic protease (Probable). Part of the necrosis cell death pathway. Involved in neuronal cell degeneration. Involved in heat stress response.	Aspartic protease 4; Aspartic protease, which is part of the necrosis cell death pathway. Involved in neuronal cell degeneration. Involved in heat stress response. Belongs to the peptidase A1 family.	0.916
asp-3	cpr-1	H22K11.1.1	C52E4.1.1	Aspartic protease 3; Aspartic protease (Probable). Part of the necrosis cell death pathway. Involved in neuronal cell degeneration. Involved in heat stress response.	Gut-specific cysteine proteinase; Thiol protease. Has a role as a digestive enzyme. Belongs to the peptidase C1 family.	0.970
asp-3	cpr-2	H22K11.1.1	F36D3.9.1	Aspartic protease 3; Aspartic protease (Probable). Part of the necrosis cell death pathway. Involved in neuronal cell degeneration. Involved in heat stress response.	Pept_C1 domain-containing protein; Belongs to the peptidase C1 family.	0.929
asp-3	cpr-3	H22K11.1.1	T10H4.12.1	Aspartic protease 3; Aspartic protease (Probable). Part of the necrosis cell death pathway. Involved in neuronal cell degeneration. Involved in heat stress response.	Cathepsin B-like cysteine proteinase 3; Belongs to the peptidase C1 family.	0.933
asp-3	cpr-4	H22K11.1.1	F44C4.3.1	Aspartic protease 3; Aspartic protease (Probable). Part of the necrosis cell death pathway. Involved in neuronal cell degeneration. Involved in heat stress response.	Cathepsin B-like cysteine proteinase 4; Thiol protease which shows activity against the fluorogenic substrate z-Arg-Arg-AMC; Belongs to the peptidase C1 family.	0.963
asp-3	cpr-5	H22K11.1.1	W07B8.5.1	Aspartic protease 3; Aspartic protease (Probable). Part of the necrosis cell death pathway. Involved in neuronal cell degeneration. Involved in heat stress response.	Cathepsin B-like cysteine proteinase 5; Belongs to the peptidase C1 family.	0.962