STRINGSTRING
pink-1 pink-1 pxl-1 pxl-1 otub-1 otub-1 cal-2 cal-2 rnf-5 rnf-5 cal-1 cal-1 hsp-70 hsp-70 mel-32 mel-32 B0563.7 B0563.7 ubc-9 ubc-9 peli-1 peli-1 rpt-4 rpt-4 rad-23 rad-23 chk-2 chk-2 ubc-13 ubc-13 Y37B11A.2 Y37B11A.2 tyms-1 tyms-1 rad-54 rad-54 pcn-1 pcn-1 cmd-1 cmd-1 T12E12.3 T12E12.3 cal-4 cal-4 hsr-9 hsr-9 rad-50 rad-50 epn-1 epn-1 R06A4.2 R06A4.2 cal-3 cal-3 smo-1 smo-1 K03A1.4 K03A1.4 math-33 math-33 cal-7 cal-7
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
pink-1Serine/threonine-protein kinase pink-1, mitochondrial; Protects against mitochondrial dysfunction during cellular stress, potentially by phosphorylating mitochondrial proteins (By similarity). Plays a role in mitophagy. (641 aa)
pxl-1Paxillin homolog 1; Required for myofilament organization of the pharyngeal sarcomeres and for pharyngeal muscle contractions and hence for pharyngeal pumping. Together with lin-8, might be required for myofilament organization in the body wall muscles ; Belongs to the paxillin family. (413 aa)
otub-1Ubiquitin thioesterase otubain-like; Hydrolase that can remove conjugated ubiquitin from proteins and plays an important regulatory role at the level of protein turnover by preventing degradation. Specifically cleaves 'Lys-48'-linked polyubiquitin. (284 aa)
cal-2CALmodulin related genes. (171 aa)
rnf-5E3 ubiquitin ligase rnf-5; E3 ubiquitin ligase that plays a role in the maintenance of muscle cell boundaries and muscle dense bodies, which establish the adhesion sites of the muscle cells to the extracellular matrix. Ubiquitinates the LIM domain protein unc-95, thereby regulating its dislocalization from muscle dense bodies and weakening the link between the muscle cells and the hypodermis. Regulation of unc-95 dissociation from muscle dense bodies by ubiquitination plays an important role in ecdysis during molting. Plays a role in the cessation of distal tip cell migration at the en [...] (235 aa)
cal-1Calmodulin-like protein; This protein resembles calmodulin in sequence but possibly resembles troponin C in function. (180 aa)
hsp-70Heat Shock Protein; Belongs to the heat shock protein 70 family. (643 aa)
mel-32Serine hydroxymethyltransferase; Interconversion of serine and glycine; Belongs to the SHMT family. (507 aa)
B0563.7Uncharacterized calcium-binding protein B0563.7. (229 aa)
ubc-9SUMO-conjugating enzyme UBC9; Accepts the ubiquitin-like protein smo-1 from the aos-1-uba-2 E1 complex and catalyzes its covalent attachment to other proteins with the help of an E3 ligase such as gei-17. Required to sumoylate the ETS transcription factor lin-1 and the Polycomb protein sop-2. Required for embryonic development, fertility, vulval morphogenesis and inhibition of vulval cell fates. Belongs to the ubiquitin-conjugating enzyme family. (166 aa)
peli-1PELI1 and PELI2 related. (458 aa)
rpt-4Probable 26S proteasome regulatory subunit 10B; The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex (By similarity). (406 aa)
rad-23Uncharacterized protein. (323 aa)
chk-2Serine/threonine-protein kinase chk-2; Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest, activation of DNA repair and apoptosis in response to the presence of DNA double-strand breaks. May also negatively regulate cell cycle progression during unperturbed cell cycles. Phosphorylates and inhibits cdc25 phosphatase, preventing entry into mitosis. Required for nuclear reorganization and homologous chromosome pairing during meiotic prophase. (476 aa)
ubc-13Ubiquitin-conjugating enzyme E2 13; Involved in protein ubiquitination, but has no ubiquitin ligase activity on its own. The uev-1-ubc-13 heterodimers catalyze the synthesis of non-canonical 'Lys-63'-linked polyubiquitin chains. Involved in sorting Lys-63-linked polyubiquitinated maternal membrane proteins for degradation by targeting to multivesicular bodies. May be involved in the ubiquitination and growth of intracellular polyglutamine protein aggregates. May have a role in AMPA-type glutamate receptor trafficking in neurons. (151 aa)
Y37B11A.2DNA polymerase. (1303 aa)
tyms-1Thymidylat_synt domain-containing protein. (312 aa)
rad-54Uncharacterized protein. (818 aa)
pcn-1Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (263 aa)
cmd-1Calmodulin; Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases. (149 aa)
T12E12.3Uncharacterized protein. (818 aa)
cal-4CALmodulin related genes. (236 aa)
hsr-9Protein hsr-9; May have a role in DNA double-strand break repair following gamma-irradiation. (1165 aa)
rad-50DNA repair protein rad-50; Essential component of the MRN complex, a complex that possesses single-stranded DNA endonuclease and 3' to 5' exonuclease activities, and plays a central role in double-strand break (DSB) repair, chromosome morphogenesis, DNA repair and meiosis. In the complex, it mediates the ATP-binding and is probably required to bind DNA ends and hold them in close proximity. (1312 aa)
epn-1ENTH domain-containing protein. (469 aa)
R06A4.2Uncharacterized protein. (837 aa)
cal-3CALmodulin related genes. (234 aa)
smo-1Small ubiquitin-related modifier; Ubiquitin-like protein which can be covalently attached to target lysines as a monomer. Does not seem to be involved in protein degradation and may function as an antagonist of ubiquitin in the degradation process. Plays a role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Covalent attachment to its substrates requires prior activation by the E1 complex aos-1-uba-2 and linkage to the E2 enzyme ubc-9, and can be promoted by an E3 ligase such as gei-17. Required for embryonic dev [...] (91 aa)
K03A1.4EF-hand domain-containing protein. (184 aa)
math-33Ubiquitin carboxyl-terminal hydrolase 7; Hydrolase that deubiquitinates target proteins. (1138 aa)
cal-7EF-hand domain-containing protein. (179 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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