STRINGSTRING
ilys-6 ilys-6 nlp-34 nlp-34 nlp-27 nlp-27 nlp-29 nlp-29 nlp-31 nlp-31 pmk-1 pmk-1 lys-7 lys-7 atf-7 atf-7 kin-4 kin-4 spp-10 spp-10 elt-2 elt-2 ilys-1 ilys-1 ilys-3 ilys-3 abf-2 abf-2 abf-1 abf-1 lys-10 lys-10 irg-5 irg-5 daf-16 daf-16 spp-1 spp-1 spp-5 spp-5 skn-1 skn-1 abf-6 abf-6 lys-1 lys-1 daf-2 daf-2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ilys-6Invertebrate-type lysozyme 6; Has bacteriolytic activity against Gram-positive bacteria. Belongs to the glycosyl hydrolase 22 family. Type-I lysozyme subfamily. (138 aa)
nlp-34Neuropeptide-Like Protein. (59 aa)
nlp-27Neuropeptide-Like Protein. (72 aa)
nlp-29Neuropeptide-like protein 29; Antimicrobial peptides that have antibacterial activity against the Gram-negative bacteria S.marcescens. Has antifungal activity against D.coniospora. May play a role in response to physical injury and osmotic stress ; Belongs to the YARP (YGGW-amide related peptide) family. (73 aa)
nlp-31Neuropeptide-like protein 31; Antimicrobial peptides that have antifungal activity against D.coniospora. Has weak antibacterial activity against Gram-positive bacteria M.luteus and Gram-negative E.coli. (75 aa)
pmk-1Mitogen-activated protein kinase pmk-1; Serine/threonine kinase which responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating downstream targets. Phosphorylates snk-1 which probably regulates skn-1 nuclear translocation in response to oxidative stress. Probably by activating skn-1, involved in the up- regulation of gcs-1 and glutathione-S-transferase gst-4 expression upon bacteria infection. Up-regulates expression of gcs-1 in intestinal cells upon arsenite treatment. Functions downstream of the MAPKK sek-1 and the MAPKKK nsy-1 as the MAP kinase [...] (377 aa)
lys-7Lysozyme-like protein 7; Plays a role in resistance to Gram-positive bacteria B.thuringiensis and M.nematophilum and Gram-negative bacteria S.boydii or S.flexneri infection and to fungus C.neoformans infection. Plays a role in susceptibility to Gram-negative bacterium S.typhimurium infection. Belongs to the glycosyl hydrolase 25 family. (283 aa)
atf-7BZIP domain-containing protein. (509 aa)
kin-4Protein KINase. (1831 aa)
spp-10SaPosin-like Protein family. (429 aa)
elt-2Transcription factor elt-2; Transcriptional activator that binds to the consensus sequence 5'-[AT]GATA[AG]-3'. Predominantly directs the transcription of intestinal genes such as ges-1, cpr-6, pho-1, ftn-1 and lev-11, and itself. Required for gut-specific differentiation, specifically acting with the GATA region-binding transcription factor elt-7 to control normal gene expression and promote normal formation of the intestine. Regulates intestinal gene expression in response to hypoxia to promote longevity. Regulates tissue specific gene expression at basal levels and in response to bac [...] (433 aa)
ilys-1Invertebrate LYSozyme. (73 aa)
ilys-3Invertebrate-type lysozyme 3; Has bacteriolytic activity against Gram-positive bacteria. Plays a role in defense against bacterial pathogens. Involved in pharyngeal grinder function by enabling proper lysis of ingested bacteria; Belongs to the glycosyl hydrolase 22 family. Type-I lysozyme subfamily. (139 aa)
abf-2Antibacterial factor-related peptide 2; Exhibits antimicrobial activity against the Gram-positive bacteria B.subtilis IFO 3134, K.varians MAFF 118076 and S.aureus ATCC 6538P, the Gram-negative bacteria A.tumefaciens MAFF 1001, B.bacteriovorus MAFF 106101 and K.pneumoniae MAFF 519002, and the yeasts C.krusei MAFF 114085, K.thermotolerans MAFF 113848 and T.delbrueckii MAFF 113811. (85 aa)
abf-1Antibacterial factor-related peptide 1. (85 aa)
lys-10LYSozyme. (230 aa)
irg-5CUB_2 domain-containing protein. (343 aa)
daf-16Forkhead box protein O; Forkhead-type transcription factor. Binds to the promoters of genes that contain the daf-16 binding element (DBE), TTGTTTAC, in their regulatory region. Functions in the Insulin/IGF-1-like signaling (IIS) mediated pathway which affects lipogenesis, lifespan, starvation survival, heat shock and oxidative stress responses, and dauer formation. Longevity signaling predominantly arises from expression in the intestine. Daf-16 transcriptional activity is negatively regulated by cytoplasmic sequestration by association with ftt-2. Inhibition is required for the carbon [...] (541 aa)
spp-1Saposin B-type domain-containing protein. (108 aa)
spp-5Saposin B-type domain-containing protein. (103 aa)
skn-1Protein skinhead-1; Transcription factor required to specify the fate of ventral blastomeres in the early embryo, and postembryonically for the development of the intestine. Directly regulates expression of zygotically expressed med-1 and med-2 to direct mesendoderm development. Required for stl-1 mRNA up- regulation in response to oxidative stress and anoxia. Required for the up-regulation of gcs-1 and several glutathione-S-transferase mRNAs in response to oxidative stress generated during pathogenic bacterial infection. In neurons, involved in mitochondrial fusion and behavioral reco [...] (623 aa)
abf-6AntiBacterial Factor related. (195 aa)
lys-1Lysozyme-like protein 1; Involved in resistance to Gram-negative bacterium S.marcescens and to bacterium Gram-positive S.aureus infection. (298 aa)
daf-2Insulin-like receptor subunit alpha; Insulin receptor-like tyrosine kinase which regulates metabolism, controls longevity and prevents developmental arrest at the dauer stage. Binding of INS family members may either stimulate, or antagonize, association of the receptor with downstream mediators such as pdk-1 and age-1. Required for germline progenitor proliferation during larval development. Required for the response to environmental stimuli such as food, pheromone, and temperature. Negatively regulates resistance to UV and oxidative stress. Role in immune function and pathogen resist [...] (1928 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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