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cdk-5 cdk-5 rab-3 rab-3 rab-1 rab-1 rab-8 rab-8 rab-5 rab-5 sph-1 sph-1 rab-14 rab-14 rab-21 rab-21 eea-1 eea-1 rab-10 rab-10 rab-7 rab-7 arf-6 arf-6 rabs-5 rabs-5 rab-35 rab-35 aex-6 aex-6 ZK970.8 ZK970.8
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
cdk-5Cyclin-dependent-like kinase 5; Proline-directed serine/threonine-protein kinase which, in several motor neurons, promotes the polarized trafficking of synaptic vesicles and dense-core vesicles (DCV). In the ventral nerve cord, phosphorylates lin-10 and thereby prevents lin-10-mediated anterograde trafficking of the glutamate receptor glr-1. Involved in the inhibition of glr-1 trafficking in hypoxic conditions. In DA motor neurons but not in DB motor neurons, regulates axonal transport of synaptic vesicle precursors by inhibiting dynein-mediated retrograde transport. Regulates the traf [...] (292 aa)
rab-3Ras-related protein Rab-3; Involved in exocytosis by regulating a late step in synaptic vesicle fusion. Could play a role in neurotransmitter release by regulating membrane flow in the nerve terminal (By similarity). Plays a role in the recruitment of endophilin unc-57 to synaptic vesicles. Probably by controlling dense-core vesicle trafficking, plays a role in the AVG neuron-mediated formation of the right axon tract of the ventral nerve cord. Belongs to the small GTPase superfamily. Rab family. (233 aa)
rab-1RAB family. (205 aa)
rab-8RAB family. (211 aa)
rab-5RAB family. (208 aa)
sph-1MARVEL domain-containing protein. (227 aa)
rab-14RAB family. (210 aa)
rab-21RAB family. (207 aa)
eea-1FYVE-type domain-containing protein. (1205 aa)
rab-10Ras-related protein Rab-10; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Required for basolateral endocytic recycling, the return of macromolecules and fluid from endosomes to the plasma membrane, in polarized epithelial cells of the intestine upstream of rm [...] (201 aa)
rab-7RAB family. (209 aa)
arf-6ADP-Ribosylation Factor related; Belongs to the small GTPase superfamily. Arf family. (175 aa)
rabs-5FYVE-type domain-containing protein. (565 aa)
rab-35RAB family. (209 aa)
aex-6Rab27. (215 aa)
ZK970.8Uncharacterized protein. (143 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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