STRINGSTRING
lys-7 lys-7 vit-5 vit-5 hsp-70 hsp-70 hsp-3 hsp-3 spp-10 spp-10 hsp-6 hsp-6 vit-2 vit-2 thn-2 thn-2 hsp-4 hsp-4 atf-6 atf-6 vit-3 vit-3 vit-4 vit-4 vit-6 vit-6 vit-1 vit-1 act-4 act-4 daf-16 daf-16 xbp-1 xbp-1 act-3 act-3 spp-1 spp-1 act-5 act-5 hsp-16.2 hsp-16.2 daf-2 daf-2 unc-22 unc-22
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
lys-7Lysozyme-like protein 7; Plays a role in resistance to Gram-positive bacteria B.thuringiensis and M.nematophilum and Gram-negative bacteria S.boydii or S.flexneri infection and to fungus C.neoformans infection. Plays a role in susceptibility to Gram-negative bacterium S.typhimurium infection. Belongs to the glycosyl hydrolase 25 family. (283 aa)
vit-5Vitellogenin-5; Precursor of the egg-yolk proteins that are sources of nutrients during embryonic development. (1603 aa)
hsp-70Heat Shock Protein; Belongs to the heat shock protein 70 family. (643 aa)
hsp-3Heat shock 70 kDa protein C; Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER. (661 aa)
spp-10SaPosin-like Protein family. (429 aa)
hsp-6Heat shock 70 kDa protein F, mitochondrial; Belongs to the heat shock protein 70 family. (657 aa)
vit-2Vitellogenin-2; Precursor of the egg-yolk proteins that are sources of nutrients during embryonic development. (1613 aa)
thn-2THaumatiN family. (233 aa)
hsp-4Endoplasmic reticulum chaperone BiP homolog; Endoplasmic reticulum chaperone that plays a key role in protein folding and quality control in the endoplasmic reticulum lumen (By similarity). Required for ER dynamics during the first embryonic cell divisions. Specifically, controls ER transition into sheet-like structures at the onset of mitosis, possibly by regulating homotypic membrane fusion. Belongs to the heat shock protein 70 family. (657 aa)
atf-6BZIP domain-containing protein. (589 aa)
vit-3Vitellogenin-3; Precursor of the egg-yolk proteins that are sources of nutrients during embryonic development. (1603 aa)
vit-4Vitellogenin-4; Precursor of the egg-yolk proteins that are sources of nutrients during embryonic development. (1603 aa)
vit-6Vitellogenin-6; Precursor of the egg-yolk proteins that are sources of nutrients during embryonic development (Probable). May play a role in cholesterol uptake. May be involved in thermotolerance. (1651 aa)
vit-1Vitellogenin-1; Precursor of the egg-yolk proteins that are sources of nutrients during embryonic development. (1616 aa)
act-4Actin-4; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. (376 aa)
daf-16Forkhead box protein O; Forkhead-type transcription factor. Binds to the promoters of genes that contain the daf-16 binding element (DBE), TTGTTTAC, in their regulatory region. Functions in the Insulin/IGF-1-like signaling (IIS) mediated pathway which affects lipogenesis, lifespan, starvation survival, heat shock and oxidative stress responses, and dauer formation. Longevity signaling predominantly arises from expression in the intestine. Daf-16 transcriptional activity is negatively regulated by cytoplasmic sequestration by association with ftt-2. Inhibition is required for the carbon [...] (541 aa)
xbp-1BZIP domain-containing protein. (335 aa)
act-3Actin-1; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. (376 aa)
spp-1Saposin B-type domain-containing protein. (108 aa)
act-5ACTin. (375 aa)
hsp-16.2Heat shock protein Hsp-16.2; Belongs to the small heat shock protein (HSP20) family. (145 aa)
daf-2Insulin-like receptor subunit alpha; Insulin receptor-like tyrosine kinase which regulates metabolism, controls longevity and prevents developmental arrest at the dauer stage. Binding of INS family members may either stimulate, or antagonize, association of the receptor with downstream mediators such as pdk-1 and age-1. Required for germline progenitor proliferation during larval development. Required for the response to environmental stimuli such as food, pheromone, and temperature. Negatively regulates resistance to UV and oxidative stress. Role in immune function and pathogen resist [...] (1928 aa)
unc-22Twitchin; Regulator of muscle contraction and relaxation. Senses mechanical strain that occurs during muscle activity by unfolding in clearly resolvable steps at differing forces. Plays a role in the organization of sarcomeres in body wall muscles ; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (7158 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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