STRINGSTRING
hop-1 hop-1 spe-4 spe-4 unc-16 unc-16 aph-2 aph-2 arl-8 arl-8 cpr-5 cpr-5 W07B8.4 W07B8.4 cpr-8 cpr-8 aph-1 aph-1 pen-2 pen-2 cpr-3 cpr-3 eea-1 eea-1 asp-4 asp-4 asp-3 asp-3 F57F5.1 F57F5.1 cpr-4 cpr-4 cpr-2 cpr-2 sel-12 sel-12 F32H5.1 F32H5.1 cpr-1 cpr-1 dli-1 dli-1 cpr-6 cpr-6
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
hop-1Presenilin hop-1; Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors (lin-12 or glp-1). Probably works redundantly of lin-12, which provides more presenilin function. (358 aa)
spe-4Presenilin spe-4; Potential catalytic subunit of the gamma-secretase complex during spermatogenesis, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors (lin-12 or glp-1) (Probable). Involved in spermatid formation during meiosis II. May be required for proper localization of macromolecules that are subject to asymmetric partitioning during spermatogenesis. (465 aa)
unc-16JNK-interacting protein; The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. May function as a regulator of synaptic vesicle transport, through interactions with the JNK-signaling components and motor proteins. Binds specific components of the JNK signaling pathway namely jnk-1, jkk-1 and sek-1. Associates with components of the motor protein, kinesin-1. Pre-assembled unc-16 scaffolding complexes are then transported as a cargo of kinesin, to the [...] (1190 aa)
aph-2Nicastrin; Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch (glp-1 or lin-12). It may represents a stabilizing cofactor required for the assembly of the gamma-secretase complex. (723 aa)
arl-8Novel small G protein indispensable for equal chromosome segregation; Belongs to the small GTPase superfamily. Arf family. (185 aa)
cpr-5Cathepsin B-like cysteine proteinase 5; Belongs to the peptidase C1 family. (344 aa)
W07B8.4Pept_C1 domain-containing protein; Belongs to the peptidase C1 family. (335 aa)
cpr-8Pept_C1 domain-containing protein; Belongs to the peptidase C1 family. (335 aa)
aph-1Gamma-secretase subunit aph-1; Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors (lin-12 or glp-1). It may represent a stabilizing cofactor for the presenilin homodimer that promotes the formation of a stable complex. Required for the localization of aph-2. (308 aa)
pen-2Gamma-secretase subunit pen-2; Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch (glp-1 or lin-12). It may represent a stabilizing cofactor for the presenilin homodimer that promotes the formation of a stable complex. Belongs to the PEN-2 family. (101 aa)
cpr-3Cathepsin B-like cysteine proteinase 3; Belongs to the peptidase C1 family. (370 aa)
eea-1FYVE-type domain-containing protein. (1205 aa)
asp-4Aspartic protease 4; Aspartic protease, which is part of the necrosis cell death pathway. Involved in neuronal cell degeneration. Involved in heat stress response. Belongs to the peptidase A1 family. (444 aa)
asp-3Aspartic protease 3; Aspartic protease (Probable). Part of the necrosis cell death pathway. Involved in neuronal cell degeneration. Involved in heat stress response. (398 aa)
F57F5.1Pept_C1 domain-containing protein; Belongs to the peptidase C1 family. (351 aa)
cpr-4Cathepsin B-like cysteine proteinase 4; Thiol protease which shows activity against the fluorogenic substrate z-Arg-Arg-AMC; Belongs to the peptidase C1 family. (335 aa)
cpr-2Pept_C1 domain-containing protein; Belongs to the peptidase C1 family. (326 aa)
sel-12Presenilin sel-12; Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors (lin-12 or glp-1). Provides the major presenilin function compared to hop-1 and spe-4. Required cell-autonomously for correct neurite connectivity of the AIY cholinergic interneurons and their correct functioning in thermotaxis. Required for mesodermal patterning of muscle function. Promotes basement membrane gap formation during tissue remodeling ; Belongs to the peptidase A22A family. (444 aa)
F32H5.1Pept_C1 domain-containing protein; Belongs to the peptidase C1 family. (356 aa)
cpr-1Gut-specific cysteine proteinase; Thiol protease. Has a role as a digestive enzyme. Belongs to the peptidase C1 family. (329 aa)
dli-1Dynein light intermediate chain; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes. (443 aa)
cpr-6Cathepsin B-like cysteine proteinase 6; Belongs to the peptidase C1 family. (379 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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