STRINGSTRING
ain-2 ain-2 mut-16 mut-16 B0511.6 B0511.6 sid-1 sid-1 ain-1 ain-1 C08A9.3 C08A9.3 mes-6 mes-6 mut-14 mut-14 prmt-5 prmt-5 rsd-3 rsd-3 eri-6 eri-6 eri-7 eri-7 drh-3 drh-3 trt-1 trt-1 rrf-3 rrf-3 tsn-1 tsn-1 drh-1 drh-1 rsd-6 rsd-6 rde-2 rde-2 ego-1 ego-1 drsh-1 drsh-1 lin-49 lin-49 rsd-2 rsd-2 mes-3 mes-3 rde-1 rde-1 hpl-1 hpl-1 gfl-1 gfl-1 R02D3.8 R02D3.8 nrde-3 nrde-3 mes-2 mes-2 ergo-1 ergo-1 epn-1 epn-1 eri-1 eri-1 rha-1 rha-1 rde-4 rde-4 gld-1 gld-1 pir-1 pir-1 Y23H5B.6 Y23H5B.6 eri-5 eri-5 xrn-1 xrn-1 smg-2 smg-2 phf-15 phf-15 smg-6 smg-6 phf-14 phf-14 gld-2 gld-2 sid-2 sid-2 chup-1 chup-1 xpo-1 xpo-1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ain-2ALG-1 INteracting protein. (748 aa)
mut-16MUTator. (1054 aa)
B0511.6RNA helicase. (544 aa)
sid-1Systemic RNA interference defective protein 1; Plays a role in RNA-mediated gene silencing by acting cell- autonomously as a channel for the transport of double-stranded RNA (dsRNA) between cells. Mediates the spread of dsRNA and subsequent silencing of genes in cells distant from the site of dsRNA introduction. Selective for dsRNA. Preferentially binds long dsRNA, from 50 base pairs up to 700. Short 20 base-pair long molecules are not bound. May also bind dsDNA, but with lower affinity. Binding may be sequence-independent. Belongs to the SID1 family. (776 aa)
ain-1ALG-1 INteracting protein. (641 aa)
C08A9.3Uncharacterized protein. (739 aa)
mes-6Polycomb protein mes-6; Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. The mes-2/mes-3/mes- 6 complex may participate in the global inactivation of the X chromosomes in germline cells. The complex may act via methylation of histone H3 'Lys-27', rendering chromatin heritably changed in its expressibility. This complex is required to ex [...] (459 aa)
mut-14MUTator; Belongs to the DEAD box helicase family. (528 aa)
prmt-5Protein arginine N-methyltransferase 5; Catalyzes the symmetrical dimethylation of arginine residues in targets such as small nuclear ribonucleoproteins, histone H2A/H4 and cbp-1. Dimethylation occurs in a distributive manner where the protein is released after the addition of the first methyl group prior to rebinding for the addition of the second methyl group. Plays a role in the negative regulation of DNA damage-induced apoptosis. By methylating cbp-1, may prevent apoptosis by repressing the capacity of cbp-1 to enhance cep-1 dependent transcription activation of the programmed cell [...] (734 aa)
rsd-3ENTH domain-containing protein. (483 aa)
eri-6Enhanced RNAI (RNA interference). (360 aa)
eri-7Enhanced RNAI (RNA interference). (625 aa)
drh-3Dicer Related Helicase. (1119 aa)
trt-1Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. (561 aa)
rrf-3RNA-dependent RNA polymerase Family. (1765 aa)
tsn-1Staphylococcal nuclease domain-containing protein; Endonuclease that mediates miRNA decay of both protein-free and AGO2-loaded miRNAs. (914 aa)
drh-1Dicer-related helicase. (1037 aa)
rsd-6Tudor domain-containing protein. (689 aa)
rde-2Uncharacterized protein. (578 aa)
ego-1RNA-directed RNA polymerase related EGO-1. (1632 aa)
drsh-1Ribonuclease 3; Executes the initial step of microRNA (miRNA) processing in the nucleus, that is the cleavage of pri-miRNA to release pre-miRNA. Involved in pre-rRNA processing. Cleaves double-strand RNA and does not cleave single-strand RNA. Involved in fertility. Required for the function or synthesis of the let-7 miRNA. Belongs to the ribonuclease III family. (1086 aa)
lin-49Protein lin-49; Essential protein required to maintain expression of homeotic genes egl-5 and mab-5. May play an analogous role to the trithorax Group (trxG) proteins. TrxG proteins form multiprotein complexes that are required to maintain the transcriptionally active state of homeotic genes throughout development. May act via a modification of chromatin. (1042 aa)
rsd-2RSD-2 domain-containing protein. (1319 aa)
mes-3Polycomb protein mes-3; Component of a Polycomb group (PcG) complex. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. The mes-2/mes-3/mes- 6 complex may participate in the global inactivation of the X chromosomes in germline cells. The complex may act via methylation of histone H3 'Lys-27', rendering chromatin heritably changed in its expressibility. This complex is [...] (754 aa)
rde-1RNA interference promoting factor RDE-1. (1020 aa)
hpl-1Heterochromatin protein 1 homolog. (184 aa)
gfl-1GAS41-Like. (211 aa)
R02D3.8Exonuclease domain-containing protein. (266 aa)
nrde-3Nuclear RNAi defective-3 protein; Transports small interfering RNAs (siRNAs) from the cytoplasm to the nucleus. Required for RNA interference (RNAi) in nuclei. Required for exogenous RNAi-induced H3K27 methylation. (1057 aa)
mes-2Histone-lysine N-methyltransferase mes-2; Polycomb group (PcG) protein. Catalytic subunit of a the mes- 2/mes-3/mes-6 complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target genes. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. The mes-2/mes-3/mes-6 complex may participate in the global inactivation of the X c [...] (773 aa)
ergo-1Piwi-like protein ergo-1; Argonaute protein required for gene silencing in the endogenous RNA interference (RNAi) pathway. Involved in the 26G RNAi pathway and associates with both unmethylated and methylated 26G small interfering RNAs (26G- siRNAs), which are a class of 26 nucleotide siRNAs that possess a guanine residue at the 5'-end. Associated 26G-siRNAs are methylated by the methyltransferase henn-1, which stabilizes the siRNAs. Association with 26G- siRNAs is required for the biogenesis of secondary 22G-siRNAs (a class of 22 nucleotide siRNAs that possess a triphosphorylated guan [...] (1121 aa)
epn-1ENTH domain-containing protein. (469 aa)
eri-13'-5' exonuclease eri-1; RNA exonuclease that acts as a negative regulator of RNA interference (RNAi). Probably acts by degrading the 3'-overhangs of short interfering RNAs (siRNAs). Its tissue specificity may help explain the inefficiency of neuronal RNAi. (582 aa)
rha-1ATP-dependent RNA helicase A; Multifunctional ATP-dependent nucleic acid helicase that unwinds DNA and RNA in a 3' to 5' direction and that plays important roles in many processes, such as DNA replication, transcriptional activation, post-transcriptional RNA regulation, mRNA translation and RNA-mediated gene silencing. Requires a 3'-single-stranded tail as entry site for acid nuclei unwinding activities as well as the binding and hydrolyzing of any of the four ribo- or deoxyribo-nucleotide triphosphates (NTPs). Binds to DNA, RNA and small interfering siRNA. Plays a role in DNA replicat [...] (1301 aa)
rde-4RNA interference promoting factor. (385 aa)
gld-1Female germline-specific tumor suppressor gld-1; RNA-binding protein which recognizes the 5'-UACUCAU-3' RNA consensus sequence. Binds sequences in both the 5'coding and the 3'-UTR region of rme-2 mRNA. Binds sequences in the 3'-UTR region of cye-1 mRNA. Binds to cyb-2.1, cyb-2.2 and cyb-3 mRNA. Binds sequences in the 3'-UTR region of tra-2 mRNA. Germ line-specific tumor suppressor essential for oogenesis. Controls the spatial pattern of translation of multiple oogenesis specific mRNAs (e.g. yolk receptor rme-2) by repression of translation during early meiotic prophase (leptotene to pa [...] (463 aa)
pir-1RNA/RNP complex-1-interacting phosphatase homolog; Possesses RNA 5'-triphosphatase and diphosphatase activities, but displays a poor protein-tyrosine phosphatase activity (By similarity). Binds RNA (By similarity). During small-RNA-mediated gene- silencing or RNA interference (RNAi), involved in the dcr-1-mediated processing of an amplified dsRNA intermediate. (233 aa)
Y23H5B.6RNA helicase. (732 aa)
eri-5Tudor domain-containing protein. (531 aa)
xrn-15'-3' exoribonuclease 1. (1591 aa)
smg-2Regulator of nonsense transcripts 1; RNA-dependent helicase and ATPase required for nonsense- mediated decay (NMD) of mRNAs containing premature stop codons. Is recruited to mRNAs upon translation termination and undergoes a cycle of phosphorylation and dephosphorylation; its phosphorylation appears to be a key step in NMD. The formation of an smg-2-3-4 surveillance complex is believed to activate NMD (By similarity). (1069 aa)
phf-15PHd Finger family. (741 aa)
smg-6PINc domain-containing protein. (1241 aa)
phf-14PHd Finger family. (599 aa)
gld-2Poly(A) RNA polymerase gld-2; Cytoplasmic poly(A) RNA polymerase that adds successive AMP monomers to the 3'-end of specific RNAs, forming a poly(A) tail. Acts as a regulator of mitosis/meiosis required for progression through meiotic prophase during oogenesis and spermatogenesis and for promotion of the entry into meiosis from the mitotic cell cycle. May act by regulating and activating gld-1 mRNA activity in germline. (1113 aa)
sid-2Systemic RNA interference defective protein 2; Plays a role in RNA-mediated gene silencing by mediating endocytic uptake of double-stranded RNA (dsRNA) ingested from the environment into intestinal cells from the intestinal lumen. Selective for dsRNAs of at least 50 bp. (311 aa)
chup-1CHolesterol UPtake associated. (756 aa)
xpo-1Importin N-terminal domain-containing protein. (1080 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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