STRINGSTRING
act-5 act-5 oma-1 oma-1 lin-41 lin-41 goa-1 goa-1 inx-6 inx-6 glp-1 glp-1 inx-14 inx-14 F15E6.3 F15E6.3 mpk-1 mpk-1 F43G6.5 F43G6.5 pos-1 pos-1 mex-3 mex-3 zif-1 zif-1 cyb-2.2 cyb-2.2 meg-1 meg-1 vab-1 vab-1 gsa-1 gsa-1 kin-2 kin-2 rnp-8 rnp-8 acy-4 acy-4 cdk-1 cdk-1 gld-3 gld-3 T15H9.6 T15H9.6 gld-1 gld-1 pap-1 pap-1 cyb-2.1 cyb-2.1 inx-21 inx-21 inx-22 inx-22 wee-1.3 wee-1.3 gld-2 gld-2 spn-4 spn-4 oma-2 oma-2 ccr-4 ccr-4 zyg-12 zyg-12 cdc-25.3 cdc-25.3 inx-8 inx-8 inx-9 inx-9 rnp-1 rnp-1 kin-1 kin-1 anc-1 anc-1
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
act-5ACTin. (375 aa)
oma-1CCCH-type zinc finger protein oma-1; Zinc-finger RNA-binding protein that binds to 5'-UA[AU]-3' motifs in the 3'-UTR of maternal mRNAs to suppress translation in oocytes and embryos. Acts as a ribonucleoprotein particle component that may exert part of its function within cytoplasmic foci of unfertilized oocytes. Acts redundantly with oma-2 to control the temporal expression and distribution of maternal proteins and thereby promote meiotic progression, oocyte maturation, fertilization and embryonic development. Recruits the translational repressor ifet-1 to the 3'-UTR of mei-1 and zif- [...] (407 aa)
lin-41Protein lin-41; Heterochronic protein which acts downstream of let-7 in temporal patterning. Plays a role in the developmental timing of postembryonic hypodermal seam cell division and fusion events and adult alae production. Represses lin-29 during late larval stages, which prevents terminal differentiation of hypodermal seam cells and promotes their division. Involved in post-transcriptional gene regulation, uses two independent pathways. Has direct and specific RNA-binding activity and, depending on the location (5'UTR or 3'UTR) of the target site, triggers either mRNA decay or repr [...] (1147 aa)
goa-1Guanine nucleotide-binding protein G(o) subunit alpha; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(o) protein function is not clear. In the 1-cell embryo, probably together with gpa-16, controls nuclear rotation and spindle elongation during mitosis. During the first embryonic cell divisions, plays a role in gpr-1/2 cortical localization and in the proper orientation of EMS blastomere mitotic spindle. Polarity determinants (par genes) may regulate lin- 5/gpr-1/gpr-2/goa-1 locally to create [...] (354 aa)
inx-6Innexin-6; Structural component of the gap junctions. Belongs to the pannexin family. (389 aa)
glp-1Protein glp-1; Involved in the specification of the cell fates of the blastomeres, ABa and APa. Proper signaling by glp-1 induces ABa descendants to produce anterior pharyngeal cells, and APa descendants to adopt a different fate. Contributes to the establishment of the dorsal-ventral axis in early embryos. Regulates germ cell mitotic proliferation probably by regulating MAP kinase phosphatase lip-1 expression. Plays a negative role in lifespan. (1295 aa)
inx-14Innexin-14; Structural component of the gap junctions. (434 aa)
F15E6.3RRM-type RNA binding protein. (118 aa)
mpk-1Mitogen-activated protein kinase mpk-1; Function in let-60 Ras signaling pathway; acts downstream of lin-45 raf kinase, but before the lin-1 gene product in controlling vulval cell differentiation. Plays a negative role in proximal germline proliferation in the mitotic zone. Required for progression of developing oocytes through the pachytene stage. In oocytes, inhibits the activity of the chloride channel clh-3, likely by activating gck-3. Plays a role in response to M.nematophilum-mediated bacterial infection by promoting tail swelling and preventing constipation. Involved in fluid h [...] (444 aa)
F43G6.5Poly(A) polymerase; Polymerase that creates the 3'-poly(A) tail of mRNA's. (554 aa)
pos-1Cytoplasmic zinc-finger protein. (264 aa)
mex-3Muscle EXcess. (443 aa)
zif-1Zinc finger-interacting factor 1; Probable substrate recognition component of a CBC (Cul2- ElonginB-ElonginC) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Ensures germline precursor cell asymmetry by targeting germline proteins for destruction if expressed in non-germline cells. This process also requires elc-1, cul-2, rbx-1 and ubc-2. (489 aa)
cyb-2.2Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (339 aa)
meg-1Uncharacterized protein. (636 aa)
vab-1Ephrin receptor 1; Receptor for members of the ephrin family (By similarity). Receptor for major sperm proteins (MSPs), that functions as sperm- sensing checkpoint which inhibits oocyte meiotic maturation and ovulation when sperm are not available for fertilization. Specifically, functions to negatively regulates oocyte maturation and MAPK activation in the absence of MSPs. Required for the MSP-mediated increase in the basal sheath cell contraction rate in somatic cells. Phosphorylates phosphatase daf-18/PTEN which probably promotes daf-18 degradation. By inactivating daf-18, regulates [...] (1122 aa)
gsa-1G protein, Subunit Alpha. (378 aa)
kin-2cAMP-dependent protein kinase regulatory subunit; Controls the rhythmic contraction of enteric muscles probably by regulating G-protein coupled receptor aex-2-mediated calcium influx in GABAergic DVB neurons; Belongs to the cAMP-dependent kinase regulatory chain family. (376 aa)
rnp-8RRM domain-containing protein. (583 aa)
acy-4Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1013 aa)
cdk-1Cyclin-dependent kinase 1; Plays a key role in the control of the eukaryotic cell cycle. It is required in higher cells for entry into S-phase and mitosis. p34 is a component of the kinase complex that phosphorylates the repetitive C-terminus of RNA polymerase II (By similarity). (332 aa)
gld-3Defective in germ line development protein 3; Required maternally for germline survival and embryogenesis. Forms a complex with gls-1 which promotes the oogenic cell fate by freeing the translational repressor fbf to repress sperm promoting factors. Promotes maturation of primary spermatocytes to mature sperm. Required during hermaphrodite development to promote sperm fate, which is critical for determining the normal number of sperm. Promotion of sperm fate is at the expense of oogenesis, possibly through the negative regulation of fbf. Required during male development for the continu [...] (969 aa)
T15H9.6Poly(A) polymerase; Polymerase that creates the 3'-poly(A) tail of mRNA's. (554 aa)
gld-1Female germline-specific tumor suppressor gld-1; RNA-binding protein which recognizes the 5'-UACUCAU-3' RNA consensus sequence. Binds sequences in both the 5'coding and the 3'-UTR region of rme-2 mRNA. Binds sequences in the 3'-UTR region of cye-1 mRNA. Binds to cyb-2.1, cyb-2.2 and cyb-3 mRNA. Binds sequences in the 3'-UTR region of tra-2 mRNA. Germ line-specific tumor suppressor essential for oogenesis. Controls the spatial pattern of translation of multiple oogenesis specific mRNAs (e.g. yolk receptor rme-2) by repression of translation during early meiotic prophase (leptotene to pa [...] (463 aa)
pap-1Poly(A) polymerase; Polymerase that creates the 3'-poly(A) tail of mRNA's. (655 aa)
cyb-2.1Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (317 aa)
inx-21Innexin; Structural component of the gap junctions. Belongs to the pannexin family. (481 aa)
inx-22Innexin; Structural component of the gap junctions. Belongs to the pannexin family. (462 aa)
wee-1.3Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase wee-1.3; Acts as a negative regulator of entry into mitosis (G2 to M transition) by phosphorylation of the CDK1 kinase during oocyte maturation. Required for oocyte maturation, embryonic development, germline proliferation and initiation of meiosis during spermatogenesis. Required for chromosome structure during mitosis and negative regulation of nuclear envelope breakdown. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. WEE1 subfamily. (677 aa)
gld-2Poly(A) RNA polymerase gld-2; Cytoplasmic poly(A) RNA polymerase that adds successive AMP monomers to the 3'-end of specific RNAs, forming a poly(A) tail. Acts as a regulator of mitosis/meiosis required for progression through meiotic prophase during oogenesis and spermatogenesis and for promotion of the entry into meiosis from the mitotic cell cycle. May act by regulating and activating gld-1 mRNA activity in germline. (1113 aa)
spn-4RRM domain-containing protein. (351 aa)
oma-2CCCH-type zinc finger protein oma-2; Zinc-finger RNA-binding protein that binds to 5'-UA[AU]-3' motifs in the 3'-UTR of maternal mRNAs to suppress translation in oocytes and embryos. Acts redundantly with oma-1 to control the temporal expression and distribution of maternal proteins and thereby promote meiotic progression, oocyte maturation, fertilization and embryonic development. Also, together with oma-1, is involved in P-granule distribution during embryonic development. (393 aa)
ccr-4Endo/exonuclease/phosphatase domain-containing protein. (677 aa)
zyg-12Zygote defective protein 12; Cytoskeletal linker protein, which is essential for attachment of the centrosome to the nucleus. Required for dynein localization to the nuclear envelope. Forms a LINC (LInker of Nucleoskeleton and Cytoskeleton) complex together with unc-84, that may be involved in DNA damage repair ; Belongs to the hook family. (777 aa)
cdc-25.3M-phase inducer phosphatase cdc-25.3. (316 aa)
inx-8Innexin-8; Structural component of the gap junctions. Belongs to the pannexin family. (382 aa)
inx-9Innexin; Structural component of the gap junctions. Belongs to the pannexin family. (382 aa)
rnp-1RNA-binding protein rnp-1; RNA-binding protein that is required for the germ line to transition from spermatogenesis to oogenesis and allow for normal oocyte development. (305 aa)
kin-1cAMP-dependent protein kinase catalytic subunit; Essential for larval development. Controls the rhythmic contraction of enteric muscles probably by regulating G- protein coupled receptor aex-2-mediated calcium influx in GABAergic DVB neurons. Plays a role in the control of oocyte meiotic maturation by gonadal sheath cells. Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily. (579 aa)
anc-1Nuclear anchorage protein 1; Plays a central role in nuclear and mitochondrial anchoring. Probably connects nuclei to the cytoskeleton by interacting with unc-84 at the nuclear envelope and with F-actin in the cytoplasm, creating a bridge across the nuclear envelope between the cytoskeleton and the nucleus. Has a role in positioning of the cell body of the PVQ lumbar interneuron. Belongs to the nesprin family. (8545 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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