STRINGSTRING
mtl-1 mtl-1 cle-1 cle-1 rrp-1 rrp-1 nrd-1 nrd-1 D1037.1 D1037.1 D1086.9 D1086.9 hlh-16 hlh-16 ncam-1 ncam-1 lev-1 lev-1 cng-1 cng-1 dip-2 dip-2 eva-1 eva-1 cng-3 cng-3 igcm-1 igcm-1 rcan-1 rcan-1 egl-4 egl-4 pdxk-1 pdxk-1 cysl-4 cysl-4 H39E23.3 H39E23.3 unc-26 unc-26 K02C4.3 K02C4.3 vglu-2 vglu-2 pad-2 pad-2 cysl-2 cysl-2 irk-2 irk-2 irk-1 irk-1 cysl-3 cysl-3 mbk-1 mbk-1 erfa-1 erfa-1 adr-2 adr-2 zig-10 zig-10 wht-6 wht-6 ace-1 ace-1 wdr-4 wdr-4 Y105E8A.1 Y105E8A.1 itsn-1 itsn-1 ace-2 ace-2 wht-8 wht-8 ace-4 ace-4 ace-3 ace-3 Y54E10A.11 Y54E10A.11 chaf-2 chaf-2 Y74C10AL.2 Y74C10AL.2 cng-2 cng-2 ubc-14 ubc-14 set-29 set-29 tax-4 tax-4 sod-5 sod-5 eat-4 eat-4 lin-15B lin-15B B0024.15 B0024.15 rnt-1 rnt-1 ikb-1 ikb-1 dgk-1 dgk-1 wht-2 wht-2 sod-1 sod-1 wht-3 wht-3 cysl-1 cysl-1 dnsn-1 dnsn-1 mtq-2 mtq-2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
mtl-1Metallothionein-1; This protein binds cations of several transition elements. (75 aa)
cle-1CoLlagen with Endostatin domain. (1175 aa)
rrp-1Ribosomal RNA processing protein 1 homolog; May be involved in the generation of 28S rRNA. Belongs to the RRP1 family. (397 aa)
nrd-1NRD (Yeast Nuclear pre-mRNA Down-regulation) homolog. (988 aa)
D1037.1Uncharacterized protein. (786 aa)
D1086.9Uncharacterized protein. (686 aa)
hlh-16BHLH domain-containing protein. (146 aa)
ncam-1NCAM (Neural cell adhesion molecule) homolog. (955 aa)
lev-1Acetylcholine receptor subunit beta-type lev-1; Non-alpha subunit of nicotinic acetylcholine receptor (nAChR). Involved in nAChR sensitivity to nicotine. Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. (507 aa)
cng-1Cyclic nucleotide-binding domain-containing protein. (661 aa)
dip-2DMAP-interaction domain-containing protein. (1681 aa)
eva-1Protein eva-1; Acts as a receptor for slt-1. Required for the guidance of the AVM pioneer axon to the ventral nerve cord. Acts as a unc-40 coreceptor to enhance the sensitivity of unc-40 to the madd-4 midline guidance cue to guide muscle arm extensions (muscle arms) and AVM mechanosensory axons towards the dorsoventral midline. Belongs to the EVA1 family. (470 aa)
cng-3Cyclic nucleotide-binding domain-containing protein. (626 aa)
igcm-1ImmunoGlobulin-like Cell adhesion Molecule family. (1073 aa)
rcan-1Calcipressin-like protein; Inhibits tax-6/calcineurin A phosphatase activity and thereby negatively regulates calcineurin-mediated functions. Plays a role in modulating temperature-dependent calcium responses in AFD neurons and in addition, also negatively regulates thermotaxis in a tax-6-dependent manner in AFD neurons. In response to changes in intracellular calcium levels may also regulate nuclear translocation of transcriptional regulators such as crtc-1. May play a role in regulating body size. Plays a role in male tail tip morphogenesis. Belongs to the RCAN family. (207 aa)
egl-4cGMP-dependent protein kinase egl-4; Promotes chemoreceptor gene expression in response to increased cGMP levels by antagonizing the gene repression functions of the class II HDAC hda-4 and the mef-2 transcription factor. Regulates gene expression via recruitment of a histone deacetylase complex containing hda-2, saeg-1 and saeg-2. Represses body size and lifespan through the dbl-1 and insulin pathways, respectively. May also signal through daf-3 and/or daf-5. Role in egg-laying, dauer formation and motility. Regulates behavioral responses to various chemosensory stimuli in sensory neu [...] (783 aa)
pdxk-1Putative pyridoxal kinase; Required for synthesis of pyridoxal-5-phosphate from vitamin B6. (331 aa)
cysl-4Cysteine synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. (337 aa)
H39E23.3Uncharacterized protein. (746 aa)
unc-26Synaptojanin; Probable inositol 5-phosphatase which regulates synaptic vesicle recycling in neurons by regulating clathrin-mediated endocytosis; In the central section; belongs to the inositol 1,4,5- trisphosphate 5-phosphatase family. (1119 aa)
K02C4.3Probable ubiquitin carboxyl-terminal hydrolase K02C4.3. (1261 aa)
vglu-2MFS domain-containing protein. (573 aa)
pad-2GDP-fucose protein O-fucosyltransferase 2; Catalyzes the reaction that attaches fucose through an O- glycosidic linkage to a conserved serine or threonine residue in the consensus sequence C1-X(2,3)-S/T-C2-X(2)-G of thrombospondin type I repeats (TSRs) where C1 and C2 are the first and second cysteines of the repeat, respectively. O-fucosylates members of several protein families including the ADAMTS superfamily and the thrombosporin (TSP) and spondin families. Required for the proper secretion of ADAMTS family members such as ADAMSL1 and ADAMST13 (By similarity). Belongs to the glycos [...] (426 aa)
cysl-2Bifunctional L-3-cyanoalanine synthase/cysteine synthase; Primarily catalyzes the formation of cyanoalanine and hydrogen sulfide from cysteine and hydrogen cyanide. Can also catalyze, although less efficiently, the formation of cyanoalanine and hydrogen sulfide from either S-sulfocysteine or O-acetylserine and hydrogen cyanide and the formation of cysteine from either S-sulfocysteine or O- acetylserine and hydrogen sulfide. By catalyzing the assimilation of cyanide produced by P.aeruginosa, mediates resistance to infection. Involved in fertility, growth and aging. Does not mediate surv [...] (337 aa)
irk-2Inward Rectifying K (Potassium) channel family. (497 aa)
irk-1Inward rectifier potassium channel irk-1; Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Required for modulation of the activity of the hermaphrodite-specific neurons (HSNs) by the G-protein coupled neuropeptide receptor egl-6 which in turn controls egg-laying behavior. (544 aa)
cysl-3Cysteine synthase 3; Primarily catalyzes the formation of cysteine and acetate from O-acetylserine and hydrogen sulfide. Can also catalyze the formation of cysteine and acetate from S-sulfocysteine and hydrogen sulfide and the formation of cyanoalanine and hydrogen sulfide from either S-sulfocysteine or O-acetylserine and hydrogen cyanide. Belongs to the cysteine synthase/cystathionine beta- synthase family. (337 aa)
mbk-1Dual specificity tyrosine-phosphorylation-regulated kinase mbk-1; Possible role in the function of olfactory neurons. Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily. (882 aa)
erfa-1Eukaryotic peptide chain release factor subunit 1; Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA. Belongs to the eukaryotic release factor 1 family. (593 aa)
adr-2Double-stranded RNA-specific adenosine deaminase adr-2; Catalyzes the hydrolytic deamination of adenosine to inosine in double-stranded RNA (dsRNA) referred to as A-to-I RNA editing. Acts primarily on non-coding regions of protein- coding genes including introns and untranslated regions (UTR). Required for normal chemotaxis. Edits the 3' UTR of clec-41 which is required for normal clec-41 expression and for chemotaxis. Plays a role in determining lifespan. Not required for RNA interference. Likely to play a role in determining whether a dsRNA enters the RNAi pathway. (495 aa)
zig-102 (Zwei) IG domain protein. (322 aa)
wht-6ABC transporter domain-containing protein. (613 aa)
ace-1Acetylcholinesterase 1; Rapidly hydrolyzes choline released into the synapse. It can hydrolyze butyrylthiocholine. (620 aa)
wdr-4tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit; Required for the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. In the complex, it is required to stabilize and induce conformational changes of the catalytic subunit. Belongs to the WD repeat TRM82 family. (391 aa)
Y105E8A.1Glutaredoxin domain-containing protein. (212 aa)
itsn-1ITSN (Intersectin) family. (1087 aa)
ace-2Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (629 aa)
wht-8ABC transporter domain-containing protein. (619 aa)
ace-4Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (602 aa)
ace-3Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (607 aa)
Y54E10A.11E3 ubiquitin-protein ligase listerin; E3 ubiquitin-protein ligase. Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation. Ubiquitination leads to vcp/p97 recruitment for extraction and degradation of the incomplete translation product; Belongs to the LTN1 family. (1446 aa)
chaf-2WD_REPEATS_REGION domain-containing protein. (489 aa)
Y74C10AL.2Uncharacterized protein. (157 aa)
cng-2Cyclic nucleotide-binding domain-containing protein. (819 aa)
ubc-14UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (170 aa)
set-29SET domain-containing protein. (401 aa)
tax-4Cyclic nucleotide-gated cation channel; Required for normal thermosensation and chemosensation sensory behavior. Required, downstream of receptor- type guanylate cyclase gcy-9, for CO2-mediated responses in BAG neurons. Required, downstream of receptor-type guanylate cyclase gcy-14, for alkaline pH-mediated responses in ASE-left (ASEL) neurons. Involved in the development of ASJ sensory neuron axon during late larval stages and in the maintenance of normal axon morphology in the adult. Regulates dauer formation. Required for the calcium flux to the cytoplasm in the ASJ sensory neurons [...] (733 aa)
sod-5Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the Cu-Zn superoxide dismutase family. (178 aa)
eat-4Probable vesicular glutamate transporter eat-4; Required for glutamatergic synaptic transmission. In AWB and AWC sensory neurons, required for the detection of preferred food sources, probably via glutamatergic neurotransmission from sensory neurons. Negatively regulates the turning step of male mating behavior. (576 aa)
lin-15BProtein lin-15B; Synthetic multivulva (synMuv) class B protein. SynMuv proteins are required to repress the induction of vulval development. Acts redundantly with SynMuv class A protein lin-15A to negatively regulate vulval development. Regulates let-23 basal activity. (1440 aa)
B0024.15Hexosyltransferase. (344 aa)
rnt-1Runt domain-containing protein. (301 aa)
ikb-1ANK_REP_REGION domain-containing protein. (597 aa)
dgk-1Diacylglycerol kinase. (952 aa)
wht-2ABC transporter domain-containing protein. (610 aa)
sod-1Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity). Required for normal brood size. May be involved in regulating mpk-1 phosphorylation downstream of phosphatase ptp-2 during oocyte maturation. (180 aa)
wht-3ABC transporter ATP-binding protein/permease wht-3; Required for efficient RNA interference (RNAi) of pop-1 indicating a role in the germline development. Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily. (614 aa)
cysl-1Cysteine synthase 1; Catalyzes the formation of cysteine and acetate from O- acetylserine and hydrogen sulfide. By metabolizing hydrogen sulfide produced by cysl-2-mediated cyanide assimilation, mediates resistance to P.aeruginosa infection. Mediates survival in high levels of hydrogen sulfide. By sequestering egl-9, which in turn promotes hif-1- mediated transcription, regulates behavioral responses to hypoxia ; Belongs to the cysteine synthase/cystathionine beta- synthase family. (341 aa)
dnsn-1Downstream Neighbor of SoN homolog. (596 aa)
mtq-2MTS domain-containing protein. (221 aa)
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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